Imperial College London
Alternate

Professor Karen Polizzi

Faculty of Engineering, Department of Chemical Engineering

Professor of Biotechnology
 
 
 
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Contact

 

+44 (0)20 7594 2851k.polizzi

 
 
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Location

 

411ACE ExtensionSouth Kensington Campus

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Summary

 

Publications

Citation

BibTex format

@article{Riangrungroj:2020:10.1111/1751-7915.13465,
author = {Riangrungroj, P and Polizzi, KM},
doi = {10.1111/1751-7915.13465},
journal = {Microbial Biotechnology},
pages = {311--314},
title = {BeQuIK (Biosensor Engineered Quorum Induced Killing): designer bacteria for destroying recalcitrant biofilms.},
url = {http://dx.doi.org/10.1111/1751-7915.13465},
volume = {13},
year = {2020}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - This opinion piece describes a new design for the remediation of recalcitrant biofilms. It builds on previous work to develop engineered E. coli that recognize quorum sensing signals from pathogens in a biofilm and secrete toxins in response. To solve the challenge of dilute signalling molecules, we propose to use nanobodies and enzymes displayed on the surface of the cells to localize them to the biofilm and degrade the extracellular polymeric substances, thus creating a solution with better 'seek and destroy' capabilities.
AU  - Riangrungroj,P
AU  - Polizzi,KM
DO  - 10.1111/1751-7915.13465
EP  - 314
PY  - 2020///
SN  - 1751-7915
SP  - 311
TI  - BeQuIK (Biosensor Engineered Quorum Induced Killing): designer bacteria for destroying recalcitrant biofilms.
T2  - Microbial Biotechnology
UR  - http://dx.doi.org/10.1111/1751-7915.13465
UR  - https://www.ncbi.nlm.nih.gov/pubmed/31328393
UR  - https://sfamjournals.onlinelibrary.wiley.com/doi/full/10.1111/1751-7915.13465
UR  - http://hdl.handle.net/10044/1/72302
VL  - 13
ER  -
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