I am currently Professor of Public Heath in the Department of Public Health and Primary Care at Imperial College London as well as Honorary Consultant Cardiologist at the Imperial College NHS Trust. I received my medical education (MB ChB, 1991) at the University of Birmingham Medical School, my MD (2004) at the University of Sheffield, a postdoctoral fellowship at Harvard Medical School and finally an MPhil in epidemiology (2007) from the University of Cambridge.
My research interests have focused on the prevention of cardiovascular disease with a special interest in lipids and diabetes. I have investigated the early benefits of statin therapy, the advantages of more/less intensive glycaemic control, and the risks/benefits of aspirin therapy. These have influenced AHA/ACC and ESC guidelines. My work on statins and diabetes risk led to a global label change for statins by the FDA and EMEA. I continue to investigate the role of lipids, lipoproteins, diabetes, inflammation and thrombosis and coronary events. I have received research grants including from the British Heart Foundation, the Wellcome Trust, Pfizer, Amgen, Sanofi, MSD, and the European Atherosclerosis Society (EAS). Currently I lead the EAS Familial Hypercholesterolaemia (FH) Studies collaboration which is the first global registry for FH and now includes approximately sixty countries, and am the Senior PI for the TOGETHER study looking at cardiometabolic risk in the vascular health checks in 250,000 people in London.
I am a Fellow of the American College of Cardiology, the European Society of Cardiology, the American Heart Association and the Royal College of Physicians, I am also a member of the British Cardiovascular Society and European Atherosclerosis Society. I have been the national lead investigator and have served on the steering and executive committees for several major medical trials. I am currently involved in eight trials including PI of ORION 1 and BETONMACE.
I have published my research in numerous journals including the NEJM, Lancet, JAMA, Archives of Internal Medicine, Circulation, the Journal of the American College of Cardiology, and the European Heart Journal, which have been cited over 12,000 times.
et al., 2018, Triglyceride-Rich Lipoprotein Cholesterol and Risk of Cardiovascular Events Among Patients Receiving Statin Therapy in the Treating to New Targets (TNT) Trial., Circulation
et al., 2018, Alirocumab vs usual lipid-lowering care as add-on to statin therapy in individuals with type 2 diabetes and mixed dyslipidaemia: The ODYSSEY DM-DYSLIPIDEMIA randomized trial., Diabetes Obes Metab
et al., 2017, Optimizing Cholesterol Treatment in Patients With Muscle Complaints, Journal of the American College of Cardiology, Vol:70, ISSN:0735-1097, Pages:1290-1301
et al., 2017, Association of Genetic Variants Related to CETP Inhibitors and Statins With Lipoprotein Levels and Cardiovascular Risk, Jama-journal of the American Medical Association, Vol:318, ISSN:0098-7484, Pages:947-956
et al., 2017, Lipid-lowering nutraceuticals in clinical practice: position paper from an International Lipid Expert Panel, Nutrition Reviews, Vol:75, ISSN:0029-6643, Pages:731-767