Imperial College London

DrKathleenSim

Faculty of MedicineDepartment of Medicine

Honorary Clinical Research Fellow
 
 
 
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Contact

 

+44 (0)20 7594 3717k.sim

 
 
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Location

 

125Wright Fleming WingSt Mary's Campus

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Summary

 

Summary

My fascination with the trillions of microbes that inhabit us combined with my paediatric background led me to join the Paediatric Microbiome Research Group. I was intrigued by the condition which primarily affects premature infants - necrotising enterocolitis (NEC). This disease has a high mortality rate and can leave survivors with devastating long term effects. Unfortunately, its aetiology is ill defined, and as result, treatment is largely supportive. I was awarded an NIHR doctoral research fellowship to undertake a study which aimed to characterise the developing faecal microbiota of preterm infants and its relation to NEC. We discovered two microbial signatures that anticipated the development of NEC and are currently exploring this in greater detail with metagenomic analysis.



Publications

Journals

Wopereis H, Sim K, Shaw A, et al., 2018, Intestinal microbiota in infants at high risk for allergy: Effects of prebiotics and role in eczema development., J Allergy Clin Immunol, Vol:141, Pages:1334-1342.e5

Shaw AG, Black N, Rushd A, et al., 2017, Assessing the Colonic Microbiota in Children: Effects of Sample Site and Bowel Preparation, Journal of Pediatric Gastroenterology and Nutrition, Vol:64, ISSN:0277-2116, Pages:230-237

Rose G, Shaw AG, Sim K, et al., 2017, Antibiotic resistance potential of the healthy preterm infant gut microbiome, Peerj, Vol:5, ISSN:2167-8359

McArdle AJ, Webbe J, Sim K, et al., 2016, Determinants of Carboxyhemoglobin Levels and Relationship with Sepsis in a Retrospective Cohort of Preterm Neonates, Plos One, Vol:11, ISSN:1932-6203

Conference

Wopereis H, Sim K, Shaw A, et al., 2016, Decreased microbial conversion of lactic acid into butyrate in infants developing eczema, Meeting of the European-Academy-of-Allergy-and-Clinical-Immunology, WILEY-BLACKWELL, Pages:168-169, ISSN:0105-4538

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