Dr Kate C. Tatham

Faculty of Medicine, Department of Surgery & Cancer

Honorary Clinical Senior Lecturer

Contact

Location

Chelsea and Westminster HospitalChelsea and Westminster Campus

Summary

I am an Honorary Clinical Senior Lecturer in Anaesthesia and Intensive Care in the Section of Anaesthetics, Pain Medicine and Intensive Care at Imperial College. I am also a consultant in Anaesthetics and Critical Care at the Royal Marsden NHS Foundation Trust.

My main research interests include the mechanisms lung injury, and the role of immune dysfunction in sepsis and inflammation.

I was awarded my PhD in 2016, for which I received a Wellcome Clinical Research Fellowship through Imperial College, and thereafter appointed as an NIHR Academic Clinical Lecturer, during which time I gained a Masters in Genomics.

Selected Publications

Journal Articles

Nelmes E, Edwards L, Jhanji S, et al.Nelmes E, Edwards L, Jhanji S, Antcliffe D, Tatham K close, 2023, Patients with cancer and sepsis trials: an unfairrepresentation?, Clinical Medicine, Vol:23, ISSN:1470-2118, Pages:635-636

Pop O-T, Geng A, Flint E, et al.Pop O-T, Geng A, Flint E, Singanayagam A, Ercan C, Possamai L, Patel VC, Kuenzler P, Meier M-A, Soysal S, Hruz P, Kollmar O, Tatham KC, Ward JK, Müllhaupt B, Weber A, Wendon J, Niess JH, Heim M, Semela D, Weston C, Antoniades CG, Terracciano LM, Triantafyllou E, Brenig RG, Bernsmeier C close, 2023, AXL expression on homeostatic resident liver macrophages is reduced in cirrhosis following GAS6 production by hepatic stellate cells, Cellular and Molecular Gastroenterology and Hepatology, Vol:16, ISSN:2352-345X, Pages:17-37

Tiu C, Shinde R, Pal A, et al.Tiu C, Shinde R, Pal A, Biondo A, Lee A, Tunariu N, Jhanji S, Grover V, Tatham K, Gruber P, Banerji U, De Bono JS, Nicholson E, Minchom AR, Lopez JS close, 2021, A wolf in sheep's clothing: systemic immune activation post immunotherapy, Journal of Immunotherapy and Precision Oncology, Vol:4, ISSN:2666-2345, Pages:189-195

Fendler A, Au L, Shepherd STC, et al.Fendler A, Au L, Shepherd STC, Byrne F, Cerrone M, Boos LA, Rzeniewicz K, Gordon W, Shum B, Gerard CL, Ward B, Xie W, Schmitt AM, Joharatnam-Hogan N, Cornish GH, Pule M, Mekkaoui L, Ng KW, Carlyle E, Edmonds K, Del Rosario L, Sarker S, Lingard K, Mangwende M, Holt L, Ahmod H, Stone R, Gomes C, Flynn HR, Agua-Doce A, Hobson P, Caidan S, Howell M, Wu M, Goldstone R, Crawford M, Cubitt L, Patel H, Gavrielides M, Nye E, Snijders AP, MacRae J, Nicod J, Gronthoud F, Shea RL, Messiou C, Cunningham D, Chau I, Starling N, Turner N, Welsh L, van As N, Jones RL, Droney J, Banerjee S, Tatham KC, Jhanji S, O'Brien M, Curtis O, Harrington K, Bhide S, Bazin J, Robinson A, Stephenson C, Slattery T, Khan Y, Tippu Z, Leslie I, Gennatas S, Okines A, Reid A, Young K, Furness AJS, Pickering L, Gandhi S, Gamblin S, Swanton C, Nicholson E, Kumar S, Yousaf N, Wilkinson KA, Swerdlow A, Harvey R, Kassiotis G, Larkin J, Wilkinson RJ, Turajlic S close, 2021, Functional antibody and T cell immunity following SARS-CoV-2 infection, including by variants of concern, in patients with cancer: the CAPTURE study, Nature Cancer, Vol:2, ISSN:2662-1347, Pages:1321-1337

Fendler A, Shepherd STC, Au L, et al.Fendler A, Shepherd STC, Au L, Wilkinson KA, Wu M, Byrne F, Cerrone M, Schmitt AM, Joharatnam-Hogan N, Shum B, Tippu Z, Rzeniewicz K, Boos LA, Harvey R, Carlyle E, Edmonds K, Del Rosario L, Sarker S, Lingard K, Mangwende M, Holt L, Ahmod H, Korteweg J, Foley T, Bazin J, Gordon W, Barber T, Emslie-Henry A, Xie W, Gerard CL, Deng D, Wall EC, Agua-Doce A, Namjou S, Caidan S, Gavrielides M, MacRae J, Kelly G, Peat K, Kelly D, Murra A, Kelly K, O'Flaherty M, Dowdie L, Ash N, Gronthoud F, Shea RL, Gardner G, Murray D, Kinnaird F, Cui W, Pascual J, Rodney S, Mencel J, Curtis O, Stephenson C, Robinson A, Oza B, Farag S, Leslie I, Rogiers A, Iyengar S, Ethell M, Messiou C, Cunningham D, Chau I, Starling N, Turner N, Welsh L, van As N, Jones RL, Droney J, Banerjee S, Tatham KC, O'Brien M, Harrington K, Bhide S, Okines A, Reid A, Young K, Furness AJS, Pickering L, Swanton C, Gandhi S, Gamblin S, Bauer DL, Kassiotis G, Kumar S, Yousaf N, Jhanji S, Nicholson E, Howell M, Walker S, Wilkinson RJ, Larkin J, Turajlic S close, 2021, Adaptive immunity and neutralizing antibodies against SARS-CoV-2 variants of concern following vaccination in patients with cancer: the CAPTURE study, Nature Cancer, Vol:2, ISSN:2662-1347, Pages:1305-1320

Tatham KC, Shankar-Hari M, Arabi YM, 2021, The REMDACTA trial: do interleukin receptor antagonists provide additional benefit in COVID-19?, Intensive Care Medicine, Vol:47, ISSN:0342-4642, Pages:1315-1318

Tatham KC, Ferguson ND, Zhou Q, et al.Tatham KC, Ferguson ND, Zhou Q, Hand L, Austin P, Taneja R, Arroliga AC, Sanchez JF, Jimenez EJ, Staub BP, Kho ME, Dominguez-Cherit JG, Mullaly A, Arabi YM, Meade MO close, 2021, Evolution of practice patterns in the management of acute respiratory distress syndrome: A secondary analysis of two successive randomized controlled trials, Journal of Critical Care, Vol:65, ISSN:0883-9441, Pages:274-281

Patel BV, Haar S, Handslip R, et al.Patel BV, Haar S, Handslip R, Auepanwiriyakul C, Lee TM-L, Patel S, Harston JA, Hosking-Jervis F, Kelly D, Sanderson B, Borgatta B, Tatham K, Welters I, Camporota L, Gordon AC, Komorowski M, Antcliffe D, Prowle JR, Puthucheary Z, Faisal AA close, 2021, Natural history, trajectory, and management of mechanically ventilated COVID-19 patients in the United Kingdom, Intensive Care Medicine, Vol:47, ISSN:0342-4642, Pages:549-565

Tatham K, Ko M, Palozzi L, et al.Tatham K, Ko M, Palozzi L, Lapinsky SE, Brochard LJ, Goligher EC close, 2020, Helmet interface increases lung volumes at equivalent ventilator pressures compared to the face mask interface during noninvasive ventilation, Critical Care (uk), Vol:24, ISSN:1364-8535

Tatham KC, McAuley DF, Borthwick M, et al.Tatham KC, McAuley DF, Borthwick M, Henderson N, Bashevoy G, Brett SJ close, 2020, The National Institute for Health Research Critical Care Research Priority Setting Survey 2018, Journal of the Intensive Care Society, Vol:21, ISSN:1751-1437, Pages:198-201

O'Dea K, Tan YY, Shah S, et al.O'Dea K, Tan YY, Shah S, Patel B, Tatham K, Wilson M, Soni S, Takata M close, 2020, Monocytes mediate homing of circulating microvesicles to the pulmonaryvasculature during low-grade systemic inflammation, Journal of Extracellular Vesicles, Vol:9, ISSN:2001-3078, Pages:1-16

Tatham KC, O'Dea KP, Romano R, et al.Tatham KC, O'Dea KP, Romano R, Donaldson HE, Wakabayashi K, Patel BV, Thakuria L, Simon AR, Sarathchandra P, POPSTAR Investigators, Marczin N, Takata M close, 2018, Intravascular donor monocytes play a central role in lung transplant ischaemia-reperfusion injury, Thorax, Vol:73, ISSN:1468-3296, Pages:350-360

Green A, Tatham KC, Yentis SM, et al.Green A, Tatham KC, Yentis SM, Wilson J, Cox M close, 2017, An analysis of the delivery of anaesthetic training sessions in the United Kingdom., Anaesthesia, Vol:72, ISSN:0003-2409, Pages:1327-1333

Kemp H, Bantel C, Gordon F, et al.Kemp H, Bantel C, Gordon F, Brett S, PLAN, SEARCH, Laycock HC close, 2017, Pain Assessment in INTensive care (PAINT): an observational study of physician-documented pain assessment in 45 intensive care units in the United Kingdom, Anaesthesia, Vol:72, ISSN:1365-2044, Pages:737-748

Patel BV, Tatham KC, Wilson MR, et al.Patel BV, Tatham KC, Wilson MR, O'Dea KP, Takata M close, 2015, In vivo compartmental analysis of leukocytes in mouse lungs, American Journal of Physiology-lung Cellular and Molecular Physiology, Vol:309, ISSN:1522-1504, Pages:L639-L652

Tatham KC, O'Dea KP, Wakabayashi K, et al.Tatham KC, O'Dea KP, Wakabayashi K, Marczin N, Takata M close, 2015, The role of ex vivo lung perfusion in lung transplantation., J Intensive Care Soc, Vol:16, ISSN:1751-1437, Pages:58-63

Tatham KC, Patel KP, 2014, Suitability of common drugs for patients who avoid animal products, British Medical Journal, Vol:4

Wakabayashi K, Wilson MR, Tatham KC, et al.Wakabayashi K, Wilson MR, Tatham KC, O'Dea KP, Takata M close, 2014, Volutrauma, but not Atelectrauma, Induces Systemic Cytokine Production by Lung-Marginated Monocytes, Critical Care Medicine, Vol:42, ISSN:0090-3493, Pages:e49-e57

Tatham K, Donaldson H, O'Dea K, et al.Tatham K, Donaldson H, O'Dea K, Wakabayashi K, Marczin N, Takata M close, 2013, Marginated monocytes play a central role in lung ischaemia-reperfusion injury in mice: Implications for lung transplantation, European Respiratory Journal, Vol:42, ISSN:0903-1936

Author Web Link

Tatham KC, Xiao W, O'Dea KP, et al.Tatham KC, Xiao W, O'Dea KP, Takata M close, 2013, Neutrophil-Dependent Shedding Of Heparan Sulfate From The Pulmonary Endothelium In An In Vitro Model Of Simulated Ischemia, American Journal of Respiratory and Critical Care Medicine, Vol:187

O'Dea KP, Dokpesi JO, Tatham KC, et al.O'Dea KP, Dokpesi JO, Tatham KC, Wilson MR, Takata M close, 2011, Regulation of monocyte subset proinflammatory responses within the lung microvasculature by the p38 MAPK/MK2 pathway, American Journal of Physiology - Lung Cellular and Molecular Physiology, Vol:301, ISSN:1040-0605, Pages:L812-L821

Tatham KC, 2006, Reduce morbidity by balancing your fluids., British Journal of Hospital Medicine, Vol:4

Books

Tatham K, Patel K, 2009, Complete OSCE Skills for Medical and Surgical Finals, Hodder Arnold, ISBN:9780340974247

Chapters

Tatham KC, Cattlin CS, Hayes, et al.Tatham KC, Cattlin CS, Hayes, MA close, 2015, Supranormal Elevation of Systemic Oxygen Delivery in Critically Ill Patients, Reducing Mortality in Critically Ill Patients, Editor(s): Landoni, Muccetti, Zangrillo, Bellomo, Springer, Pages:93-102

Conference

Smith S, Edwards L, Wigmore T, et al.Smith S, Edwards L, Wigmore T, Jhanji S, Antcliffe D, Tatham K close, 2023, Survival of patients with solid tumors and sepsis admitted to intensive care in a tertiary oncology center: A retrospective analysis, Annual Meeting of the American-Society-of-Clinical-Oncology (ASCO), LIPPINCOTT WILLIAMS & WILKINS, ISSN:0732-183X

Author Web Link

Soni S, Romano R, O'Dea K, et al.Soni S, Romano R, O'Dea K, Patel B, Tatham K, Koh M, Tsiridou D, Simon A, Thakuria L, Wilson M, Reed A, Marczin N, Takata M close, 2020, Intra-alveolar neutrophil-derived microvesicles predict development of primary graft dysfunction after lung transplantation, 2020 ERS International Congress, European Respiratory Society, Pages:1-2, ISSN:0903-1936

Tatham KC, O'Dea KP, Romano R, et al.Tatham KC, O'Dea KP, Romano R, Donaldson H, Thakuria L, Wakabayashi K, Patel BV, Reed A, Simon A, Marczin N, Takata M close, 2016, Retention And Activation Of Donor Vascular Monocytes In Transplanted Lungs Suggests A Central Role In Primary Graft Dysfunction, International Conference of the American-Thoracic-Society (ATS), AMER THORACIC SOC, ISSN:1073-449X

Author Web Link

Tatham KC, Laycock H, Wordsworth H, 2016, Pain Assessment In Cardiothoracic Intensive Care Units: A Snapshot Audit Of Practice In London Intensive Care Units, International Conference of the American-Thoracic-Society (ATS), AMER THORACIC SOC, ISSN:1073-449X

Author Web Link

Patel BV, Tatham KC, Wilson MR, et al.Patel BV, Tatham KC, Wilson MR, O'Dea K, Takata M close, 2015, In Vivo Compartmental Labeling of the Mouse Lung, American Thoracic Society, ATS Journals, Pages:A3926-A3926, ISSN:1073-449X

Donaldson H, Tatham K, Odea K, et al.Donaldson H, Tatham K, Odea K, Wakabayashi K, Marczin N, Takata M close, 2014, Subclinical endotoxaemia enhances lung ischaemia-reperfusion injury, Winter Meeting of the Anaesthetic-Research-Society (ARS), OXFORD UNIV PRESS, Pages:184P-185P, ISSN:0007-0912

Author Web Link

Wakabayashi K, Wilson M, Tatham K, et al.Wakabayashi K, Wilson M, Tatham K, O'Dea K, Takata M close, 2013, High-stretch, but not atelectasis, causes systemic cytokine release by lung-marginated monocytes, EUROPEAN RESPIRATORY SOC JOURNALS LTD, ISSN:0903-1936

Author Web Link

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