Imperial College London


Faculty of Natural SciencesDepartment of Chemistry

Chair in Chemical Biology



+44 (0)20 7594 5837keith.willison Website CV




301FMolecular Sciences Research HubWhite City Campus





The group’s research interests cover a range of topics including eukaryotic protein folding and single molecule approaches to protein dynamics and protein counting. Everything we do involves interdisciplinary approaches to biological research problems – we collaborate with physicists, mathematicians and engineers across Imperial College.

We were founder members of the  Centre for Doctoral Training in Chemical Biology and the Institute of Chemical Biology. The EPSRC-funded CDT started life in 2003 and was recently renewed for a 4th round of student intake from 2019-2024. In the first three CDT programmes we trained around 150 PhDs in Chemical Biology subjects ranging from optics, spectroscopies, microfluidics and other physical science-based platforms to biological problems such as artificial vesicles/cells and cancer drug discovery.



Ying L, Teng X, Sheveleva A, et al., 2021, Acetylation rather than H50Q Mutation Impacts the Kinetics of Cu(II) Binding to α-Synuclein, Chemphyschem: a European Journal of Chemical Physics and Physical Chemistry, ISSN:1439-4235

Klug D, Osman S, Bendtsen C, et al., 2021, Evaluation of FOXO1 target engagement using a single-cell microfluidic platform, Analytical Chemistry, ISSN:0003-2700

Wang X, Wilkinson MD, Lin X, et al., 2020, Correction: Single-molecule nanopore sensing of actin dynamics and drug binding, Chemical Science, Vol:11, ISSN:2041-6520, Pages:8036-8038

Ying L, Tahirbegi B, Magness A, et al., 2020, A novel Aβ40 assembly at physiological concentration, Scientific Reports, Vol:10, ISSN:2045-2322


Teng X, Probing the Interactions of Intrinsically Disordered Protein with Metal Ions and Lipid Membranes by Fluorescence Spectroscopy, 65th Annual Meeting of The Biophysical Society

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