Dr Kirsten McEwen is a Fellow at Imperial College London investigating transcriptional heterogeneity. Kirsten’s research integrates interdisciplinary approaches to uncover molecular mechanisms of disease. She was awarded an Imperial Junior Research Fellowship in December 2015 to establish her research programme in the Department of Life Sciences.
Dr McEwen previously held a post-doctoral position at the MRC Clinical Sciences Centre, part of the Institute of Clinical Sciences at Imperial College London. Her research investigated the molecular characteristics of pluripotency and identified epigenetic states now used as a benchmark for naïve human pluripotent stem cells. Kirsten holds a PhD from the University of Cambridge where she identified regulatory signatures of allele-specific gene expression. Dr McEwen’s expertise in gene regulation and computational methods is applied towards understanding the functions and mechanisms of heterogeneity in health and disease.
Amouroux R, McEwen KR, Hajkova P, Current technological advances in mapping new DNA modifications, Drug Discovery Today: Disease Models, Vol:12, ISSN:1740-6757, Pages:15-26
et al., 2011, Postnatal loss of Dlk1 imprinting in stem cells and niche astrocytes regulates neurogenesis, Nature, Vol:475, ISSN:0028-0836, Pages:381-U136
et al., 2013, The impact of culture on epigenetic properties of pluripotent stem cells and pre-implantation embryos, Biochemical Society Transactions, Vol:41, ISSN:0300-5127, Pages:711-719
McEwen KR, Ferguson-Smith AC, 2010, Distinguishing epigenetic marks of developmental and imprinting regulation., Epigenetics & Chromatin, Vol:3, ISSN:1756-8935
et al., 2013, Naive pluripotency is associated with global DNA hypomethylation, Nature Structural & Molecular Biology, Vol:20, ISSN:1545-9993, Pages:311-316