Imperial College London


Faculty of Natural SciencesDepartment of Life Sciences




kirsten.mcewen Website




316Sir Ernst Chain BuildingSouth Kensington Campus





Dr Kirsten McEwen is a Fellow at Imperial College London investigating transcriptional heterogeneity. Kirsten’s research integrates interdisciplinary approaches to uncover molecular mechanisms of disease. She was awarded an Imperial Junior Research Fellowship in December 2015 to establish her research programme in the Department of Life Sciences.

Dr McEwen previously held a post-doctoral position at the MRC Clinical Sciences Centre, part of the Institute of Clinical Sciences at Imperial College London. Her research investigated the molecular characteristics of pluripotency and identified epigenetic states now used as a benchmark for naïve human pluripotent stem cells. Kirsten holds a PhD from the University of Cambridge where she identified regulatory signatures of allele-specific gene expression. Dr McEwen’s expertise in gene regulation and computational methods is applied towards understanding the functions and mechanisms of heterogeneity in health and disease.

Selected Publications

Journal Articles

Amouroux R, McEwen KR, Hajkova P, 2014, Current technological advances in mapping new DNA modifications, Drug Discovery Today: Disease Models, Vol:12, ISSN:1740-6757, Pages:15-26

McEwen KR, Leitch HG, Amouroux R, et al., 2013, The impact of culture on epigenetic properties of pluripotent stem cells and pre-implantation embryos, Biochemical Society Transactions, Vol:41, ISSN:0300-5127, Pages:711-719

Leitch HG, McEwen KR, Turp A, et al., 2013, Naive pluripotency is associated with global DNA hypomethylation, Nature Structural & Molecular Biology, Vol:20, ISSN:1545-9993, Pages:311-316

Ferron SR, Charalambous M, Radford E, et al., 2011, Postnatal loss of Dlk1 imprinting in stem cells and niche astrocytes regulates neurogenesis, Nature, Vol:475, ISSN:0028-0836, Pages:381-U136

McEwen KR, Ferguson-Smith AC, 2010, Distinguishing epigenetic marks of developmental and imprinting regulation., Epigenetics & Chromatin, Vol:3, ISSN:1756-8935

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