Dr Kirsten McEwen is a Fellow at Imperial College London investigating molecular mechanisms of disease. Kirsten’s research is focused on transcriptional and epigenetic processes in stem cells, with application to haploinsufficient disease. Awarded an Imperial College Research Fellowship, Dr McEwen has established her laboratory in the Department of Life Sciences combining experimental and theoretical biology.
Dr McEwen previously worked as a Career Development Fellow at the MRC Clinical Sciences Centre, part of the Institute of Clinical Science at Imperial College London. Her research investigated the molecular characteristics of pluripotency, comparing two growth conditions as a model for investigating transcriptional and epigenetic processes of pluripotency. She holds a PhD in stem cell epigenetics from the University of Cambridge, focused on epigenetic regulation of genomic imprinting. Dr McEwen’s expertise in gene dosage and regulation is applied to understanding the molecular mechanisms of disease. See the research and publications section for further details of current work.
Amouroux R, McEwen KR, Hajkova P, Current technological advances in mapping new DNA modifications, Drug Discovery Today: Disease Models, Vol:12, ISSN:1740-6757, Pages:15-26
et al., 2011, Postnatal loss of Dlk1 imprinting in stem cells and niche astrocytes regulates neurogenesis, Nature, Vol:475, ISSN:0028-0836, Pages:381-U136
et al., 2013, The impact of culture on epigenetic properties of pluripotent stem cells and pre-implantation embryos, Biochemical Society Transactions, Vol:41, ISSN:0300-5127, Pages:711-719
McEwen KR, Ferguson-Smith AC, 2010, Distinguishing epigenetic marks of developmental and imprinting regulation., Epigenetics & Chromatin, Vol:3, ISSN:1756-8935
et al., 2013, Naive pluripotency is associated with global DNA hypomethylation, Nature Structural & Molecular Biology, Vol:20, ISSN:1545-9993, Pages:311-316