Imperial College London

DrLeandroCastellano

Faculty of MedicineDepartment of Surgery & Cancer

Visiting Reader
 
 
 
//

Contact

 

+44 (0)20 7594 2822l.castellano Website

 
 
//

Location

 

ICTEM buildingHammersmith Campus

//

Summary

 

Summary

Within tumours, individual cells often differ genetically while also transitioning between specific cell states linked to disease progression and treatment failure. 

Dr Castellano's group is investigating how non-coding RNAs (ncRNAs) interacting with proteins and DNA control these phenotypes. 

ncRNAs can be short (< 200bp) including the class of microRNAs or longer (> 200bp) and called long non-coding RNAs: both are often dysregulated in cancers, either enhancing or slowing oncogenesis by various mechanisms.  By focusing on the roles of these non-coding RNAs in orchestrating transitions, such as the epithelial-mesenchymal transition that facilitates metastasis, and the differentiation of stem-like tumour cells into differentiated progeny, we hope to elucidate functions of this previously unrecognised layer of regulatory RNAs.

Non-coding RNAs implicated in maintaining these tumour cell states can then offer diagnostic, prognostic and therapeutic potential once their contribution to tumour behaviour is established. Interested candidates with relevant skills and expertise may contact Dr Castellano.

Publications

Journals

Zagorac S, de Giorgio A, Dabrowska A, et al., 2020, SCIRT lncRNA restrains tumorigenesis by opposing transcriptional programs of tumor-initiating cells., Cancer Research, ISSN:0008-5472

Ottaviani S, Stebbing J, Frampton AE, et al., 2019, Author Correction: TGF-beta induces miR-100 and miR-125b but blocks let-7a through LIN28B controlling PDAC progression, Nature Communications, Vol:10, ISSN:2041-1723

Nguyen VTM, Barozzi I, Faronato M, et al., 2019, Author Correction: Differential epigenetic reprogramming in response to specific endocrine therapies promotes cholesterol biosynthesis and cellular invasion, Nature Communications, Vol:10, ISSN:2041-1723

Malczewska A, Frampton AE, Mato Prado M, et al., 2019, Circulating microRNAs in small-bowel neuroendocrine tumors: A potential tool for diagnosis and assessment of effectiveness of surgical resection., Annals of Surgery, ISSN:0003-4932, Pages:1-9

Conference

Chrysostomou S, Roy R, Prischi F, et al., 2019, Targeting RSK4 prevents both chemoresistance and metastasis in lung cancer, AACR Annual Meeting on Bioinformatics, Convergence Science, and Systems Biology, AMER ASSOC CANCER RESEARCH, ISSN:0008-5472

More Publications