Publications
94 results found
Krell J, Frampton AE, Colombo T, et al., 2013, The p53 miRNA interactome and its potential role in the cancer clinic, EPIGENOMICS, Vol: 5, Pages: 417-428, ISSN: 1750-1911
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- Citations: 26
Frampton AE, Fletcher CE, Gall TMH, et al., 2013, Circulating peripheral blood mononuclear cells exhibit altered miRNA expression patterns in pancreatic cancer, EXPERT REVIEW OF MOLECULAR DIAGNOSTICS, Vol: 13, Pages: 425-430, ISSN: 1473-7159
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- Citations: 19
Frampton AE, Gall TMH, Giovannetti E, et al., 2013, Distinct miRNA profiles are associated with malignant transformation of pancreatic cystic tumors revealing potential biomarkers for clinical use, EXPERT REVIEW OF MOLECULAR DIAGNOSTICS, Vol: 13, Pages: 325-329, ISSN: 1473-7159
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- Citations: 9
Pellegrino L, Stebbing J, Braga VM, et al., 2013, miR-23b regulates cytoskeletal remodeling, motility and metastasis by directly targeting multiple transcripts, Nucleic Acids Research, Vol: 41, Pages: 5400-5412, ISSN: 1362-4962
Uncontrolled cell proliferation and cytoskeletal remodeling are responsible for tumor development and ultimately metastasis. A number of studies have implicated microRNAs in the regulation of cancer cell invasion and migration. Here, we show that miR-23b regulates focal adhesion, cell spreading, cell-cell junctions and the formation of lamellipodia in breast cancer (BC), implicating a central role for it in cytoskeletal dynamics. Inhibition of miR-23b, using a specific sponge construct, leads to an increase of cell migration and metastatic spread in vivo, indicating it as a metastatic suppressor microRNA. Clinically, low miR-23b expression correlates with the development of metastases in BC patients. Mechanistically, miR-23b is able to directly inhibit a number of genes implicated in cytoskeletal remodeling in BC cells. Through intracellular signal transduction, growth factors activate the transcription factor AP-1, and we show that this in turn reduces miR-23b levels by direct binding to its promoter, releasing the pro-invasive genes from translational inhibition. In aggregate, miR-23b expression invokes a sophisticated interaction network that co-ordinates a wide range of cellular responses required to alter the cytoskeleton during cancer cell motility.
Gall TMH, Frampton AE, Krell J, et al., 2013, Blood-based miRNAs as noninvasive diagnostic and surrogative biomarkers in colorectal cancer, EXPERT REVIEW OF MOLECULAR DIAGNOSTICS, Vol: 13, Pages: 141-145, ISSN: 1473-7159
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- Citations: 12
Gall TMH, Frampton AE, Krell J, et al., 2013, Circulating molecular markers in pancreatic cancer: ready for clinical use?, FUTURE ONCOLOGY, Vol: 9, Pages: 141-144, ISSN: 1479-6694
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- Citations: 3
Castellano L, Stebbing J, 2013, Deep sequencing of small RNAs identifies canonical and non-canonical miRNA and endogenous siRNAs in mammalian somatic tissues, Nucleic Acids Research, Vol: 41, Pages: 3339-3351, ISSN: 1362-4962
MicroRNAs (miRNAs) are small RNA molecules that regulate gene expression. They are characterized by specific maturation processes defined by canonical and non-canonical biogenic pathways. Analysis of ∼0.5 billion sequences from mouse data sets derived from different tissues, developmental stages and cell types, partly characterized by either ablation or mutation of the main proteins belonging to miRNA processor complexes, reveals 66 high-confidence new genomic loci coding for miRNAs that could be processed in a canonical or non-canonical manner. A proportion of the newly discovered miRNAs comprises mirtrons, for which we define a new sub-class. Notably, some of these newly discovered miRNAs are generated from untranslated and open reading frames of coding genes, and we experimentally validate these. We also show that many annotated miRNAs do not present miRNA-like features, as they are neither processed by known processing complexes nor loaded on AGO2; this indicates that the current miRNA miRBase database list should be refined and re-defined. Accordingly, a group of them map on ribosomal RNA molecules, whereas others cannot undergo genuine miRNA biogenesis. Notably, a group of annotated miRNAs are Dgcr8 independent and DICER dependent endogenous small interfering RNAs that derive from a unique hairpin formed from a short interspersed nuclear element.
Pellegrino L, Jacob J, Roca-Alonso L, et al., 2013, Altered expression of the miRNA processing endoribonuclease Dicer has prognostic significance in human cancers, EXPERT REVIEW OF ANTICANCER THERAPY, Vol: 13, Pages: 21-27, ISSN: 1473-7140
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- Citations: 13
Frampton AE, Gall TMH, Castellano L, et al., 2013, Towards a clinical use of miRNAs in pancreatic cancer biopsies, EXPERT REVIEW OF MOLECULAR DIAGNOSTICS, Vol: 13, Pages: 31-34, ISSN: 1473-7159
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- Citations: 16
Pellegrino L, Krell J, Roca-Alonso L, et al., 2013, MicroRNA-23b regulates cellular architecture and impairs motogenic and invasive phenotypes during cancer progression., Bioarchitecture, Vol: 3, Pages: 119-124
The cytoskeleton is a dynamic three dimensional structure contained within the cytoplasm of a cell, and is important in cell shape and movement, and in metastatic progression during carcinogenesis. Members of the Rho family of small GTPases, RHO, RAC and cell cycle division 42 (Cdc42) proteins regulate cytoskeletal dynamics, through the control of a panel of genes. We have recently shown that the microRNA (miRNA) miR-23b represents a central effector of cytoskeletal remodelling. It increases cell-cell interactions, modulates focal adhesion and reduces cell motility and invasion by directly regulating several genes involved in these processes.
Frampton AE, Krell J, Zhang Y, et al., 2012, The role of miR-10b in metastatic pancreatic ductal adenocarcinoma, SURGERY, Vol: 152, Pages: 936-938, ISSN: 0039-6060
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- Citations: 6
Zabron AA, Frampton AE, Krell J, et al., 2012, MicroRNAs in malignant bile as diagnostic biomarkers for pancreatic ductal adenocarcinoma., UEGW, Pages: A119-A119
Frampton AE, Krell J, Giovannetti E, et al., 2012, Defining a prognostic molecular profile for ductal adenocarcinoma of the pancreas highlights known key signaling pathways, EXPERT REVIEW OF ANTICANCER THERAPY, Vol: 12, Pages: 1275-1278, ISSN: 1473-7140
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- Citations: 3
Frampton AE, Krell J, Jacob J, et al., 2012, Loss of miR-126 is crucial to pancreatic cancer progression, EXPERT REVIEW OF ANTICANCER THERAPY, Vol: 12, Pages: 881-884, ISSN: 1473-7140
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- Citations: 37
Ezra DG, Krell J, Rose GE, et al., 2012, Transcriptome-level microarray expression profiling implicates IGF-1 and Wnt signalling dysregulation in the pathogenesis of thyroid-associated orbitopathy, JOURNAL OF CLINICAL PATHOLOGY, Vol: 65, Pages: 608-613, ISSN: 0021-9746
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- Citations: 29
Jacob J, Frampton AE, Castellano L, et al., 2012, Retinoblastoma protein determines aggressiveness in triple-negative breast cancer, EXPERT REVIEW OF ANTICANCER THERAPY, Vol: 12, Pages: 581-584, ISSN: 1473-7140
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- Citations: 3
Britton D, Stebbing J, Alonso LR, et al., 2012, Liquid chromatography - mass spectrometry proteomics to monitor the activity of multiple phosphorylation signaling pathways in cancer, CANCER RESEARCH, Vol: 72, ISSN: 0008-5472
Krell J, Frampton AE, Jacob J, et al., 2012, miRNAs in breast cancer: ready for real time?, PHARMACOGENOMICS, Vol: 13, Pages: 709-719, ISSN: 1462-2416
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- Citations: 13
Frampton AE, Krell J, Pellegrino L, et al., 2012, Integrated analysis of miRNA and mRNA profiles enables target acquisition in human cancers, EXPERT REVIEW OF ANTICANCER THERAPY, Vol: 12, Pages: 323-330, ISSN: 1473-7140
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- Citations: 2
Jiao LR, Frampton AE, Jacob J, et al., 2012, MicroRNAs Targeting Oncogenes Are Down-Regulated in Pancreatic Malignant Transformation from Benign Tumors, PLOS ONE, Vol: 7, ISSN: 1932-6203
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- Citations: 109
Roca-Alonso L, Pellegrino L, Castellano L, et al., 2012, Breast Cancer Treatment and Adverse Cardiac Events: What Are the Molecular Mechanisms?, CARDIOLOGY, Vol: 122, Pages: 253-259, ISSN: 0008-6312
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- Citations: 31
Krell J, Frampton AE, Jacob J, et al., 2012, The Clinico-Pathologic Role of MicroRNAs miR-9 and miR-151-5p in Breast Cancer Metastasis, MOLECULAR DIAGNOSIS & THERAPY, Vol: 16, Pages: 167-172, ISSN: 1177-1062
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- Citations: 35
Frampton AE, Krell J, Jacob J, et al., 2011, microRNAs as markers of survival and chemoresistance in pancreatic ductal adenocarcinoma, EXPERT REVIEW OF ANTICANCER THERAPY, Vol: 11, Pages: 1837-1842, ISSN: 1473-7140
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- Citations: 21
Jacob J, Krell J, Castellano L, et al., 2011, Determination of cut-offs for circulating tumor cell measurement in metastatic cancer, EXPERT REVIEW OF ANTICANCER THERAPY, Vol: 11, Pages: 1345-1350, ISSN: 1473-7140
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- Citations: 9
Giamas G, Filipovic A, Messier W, et al., 2011, Kinome Screening for Regulators of Estrogen Receptor Identifies a Novel Kinase as a New Therapeutic Target in Breast Cancer.
Jacob J, Stebbing J, Frampton A, et al., 2010, MicroRNAs and RNA-binding proteins, Advances in Breast Cancer, Vol: 7, Pages: 6-9, ISSN: 1742-0946
Frampton AE, Castellano L, Tsim N, et al., 2010, MicroRNA expression profiles in pancreatic cystic tumors, JOURNAL OF CLINICAL ONCOLOGY, Vol: 28, ISSN: 0732-183X
Stebbing J, Wickenden C, Castellano L, et al., 2010, No evidence for a polyomavirus association or aetiology in AIDS-associated nonsmall cell lung cancer, AIDS, Vol: 24, Pages: 1221-1223, ISSN: 0269-9370
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- Citations: 4
Wickenden C, Castellano L, Jacob J, et al., 2010, No evidence for a viral association or aetiology in pancreatic cancer, MOLECULAR IMMUNOLOGY, Vol: 47, Pages: 639-639, ISSN: 0161-5890
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- Citations: 1
Castellano L, Giamas G, Jacob J, et al., 2009, The estrogen receptor-α-induced microRNA signature regulates itself and its transcriptional response, PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, Vol: 106, Pages: 15732-15737, ISSN: 0027-8424
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- Citations: 282
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