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@article{Ottaviani:2018:10.1080/23723556.2018.1499066,
author = {Ottaviani, S and Castellano, L},
doi = {10.1080/23723556.2018.1499066},
journal = {Molecular & Cellular Oncology},
pages = {1--3},
title = {microRNAs: novel regulators of the TGF- pathway in pancreatic ductal adenocarcinoma},
url = {http://dx.doi.org/10.1080/23723556.2018.1499066},
volume = {5},
year = {2018}
}

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TY  - JOUR
AB  - We identified that transforming growth factor-β (TGF-β) induces long non-coding RNA (lncRNA) MIR100HG along with its host microRNAs (miRNAs) miR-100 and miR-125b, to regulate its response in pancreatic ductal adenocarcinoma (PDAC). Importantly let-7a, despite originating from MIR100HG, remains unchanged because post-transcriptionally repressed by lin-28 homolog B (LIN28B). A novel method for global miRNA-target discovery identified that miR-100/125b regulates crucial PDAC pathways.
AU  - Ottaviani,S
AU  - Castellano,L
DO  - 10.1080/23723556.2018.1499066
EP  - 3
PY  - 2018///
SN  - 2372-3556
SP  - 1
TI  - microRNAs: novel regulators of the TGF- pathway in pancreatic ductal adenocarcinoma
T2  - Molecular & Cellular Oncology
UR  - http://dx.doi.org/10.1080/23723556.2018.1499066
UR  - https://www.tandfonline.com/doi/full/10.1080/23723556.2018.1499066
UR  - http://hdl.handle.net/10044/1/62177
VL  - 5
ER  -

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