Imperial College London
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DrLeandroCastellano

Faculty of Medicine, Department of Surgery & Cancer

Visiting Reader
 
 
 
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Contact

 

+44 (0)20 7594 2822l.castellano Website

 
 
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Location

 

ICTEM buildingHammersmith Campus

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Summary

 

Publications

Citation

BibTex format

@article{Macdougall:2018:10.1016/j.cmet.2018.02.007,
author = {Macdougall, CE and Wood, EG and Loschko, J and Scagliotti, V and Cassidy, FC and Robinson, ME and Feldhahn, N and Castellano, L and Voisin, M-B and Marelli-Berg, F and Gaston-Massuet, C and Charalambous, M and Longhi, MP},
doi = {10.1016/j.cmet.2018.02.007},
journal = {Cell Metabolism},
pages = {588--601.e4},
title = {Visceral adipose tissue immune homeostasis Is regulated by the crosstalk between adipocytes and dendritic cell subsets},
url = {http://dx.doi.org/10.1016/j.cmet.2018.02.007},
volume = {27},
year = {2018}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - Visceral adipose tissue (VAT) has multiple roles in orchestrating whole-body energy homeostasis. In addition, VAT is now considered an immune site harboring an array of innate and adaptive immune cells with a direct role in immune surveillance and host defense. We report that conventional dendritic cells (cDCs) in VAT acquire a tolerogenic phenotype through upregulation of pathways involved in adipocyte differentiation. While activation of the Wnt/β-catenin pathway in cDC1 DCs induces IL-10 production, upregulation of the PPARγ pathway in cDC2 DCs directly suppresses their activation. Combined, they promote an anti-inflammatory milieu in vivo delaying the onset of obesity-induced chronic inflammation and insulin resistance. Under long-term over-nutrition, changes in adipocyte biology curtail β-catenin and PPARγ activation, contributing to VAT inflammation.
AU  - Macdougall,CE
AU  - Wood,EG
AU  - Loschko,J
AU  - Scagliotti,V
AU  - Cassidy,FC
AU  - Robinson,ME
AU  - Feldhahn,N
AU  - Castellano,L
AU  - Voisin,M-B
AU  - Marelli-Berg,F
AU  - Gaston-Massuet,C
AU  - Charalambous,M
AU  - Longhi,MP
DO  - 10.1016/j.cmet.2018.02.007
EP  - 601
PY  - 2018///
SN  - 1550-4131
SP  - 588
TI  - Visceral adipose tissue immune homeostasis Is regulated by the crosstalk between adipocytes and dendritic cell subsets
T2  - Cell Metabolism
UR  - http://dx.doi.org/10.1016/j.cmet.2018.02.007
UR  - https://www.sciencedirect.com/science/article/pii/S1550413118301189?via%3Dihub
UR  - http://hdl.handle.net/10044/1/58337
VL  - 27
ER  -
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