Imperial College London

DrLachlanCoin

Faculty of MedicineDepartment of Medicine

Honorary Senior Lecturer
 
 
 
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Contact

 

+44 (0)20 7594 1930l.coin

 
 
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Location

 

172Medical SchoolSt Mary's Campus

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Summary

 

Publications

Publication Type
Year
to

87 results found

Elliott AG, Ganesamoorthy D, Coin L, Cooper MA, Cao MDet al., 2016, Complete Genome Sequence of Klebsiella quasipneumoniae subsp. similipneumoniae Strain ATCC 700603., Genome Announc, Vol: 4, ISSN: 2169-8287

Klebsiella quasipneumoniae subsp. similipneumoniae strain ATCC 700603, formerly known as K. pneumoniae K6, is known for producing extended-spectrum β-lactamase (ESBL) enzymes that can hydrolyze oxyimino-β-lactams, resulting in resistance to these drugs. We herein report the complete genome of strain ATCC 700603 and show that the ESBL genes are plasmid-encoded.

JOURNAL ARTICLE

Li J, Woods SL, Healey S, Beesley J, Chen X, Lee JS, Sivakumaran H, Wayte N, Nones K, Waterfall JJ, Pearson J, Patch A-M, Senz J, Ferreira MA, Kaurah P, Mackenzie R, Heravi-Moussavi A, Hansford S, Lannagan TRM, Spurdle AB, Simpson PT, da Silva L, Lakhani SR, Clouston AD, Bettington M, Grimpen F, Busuttil RA, Di Costanzo N, Boussioutas A, Jeanjean M, Chong G, Fabre A, Olschwang S, Faulkner GJ, Bellos E, Coin L, Rioux K, Bathe OF, Wen X, Martin HC, Neklason DW, Davis SR, Walker RL, Calzone KA, Avital I, Heller T, Koh C, Pineda M, Rudloff U, Quezado M, Pichurin PN, Hulick PJ, Weissman SM, Newlin A, Rubinstein WS, Sampson JE, Hamman K, Goldgar D, Poplawski N, Phillips K, Schofield L, Armstrong J, Kiraly-Borri C, Suthers GK, Huntsman DG, Foulkes WD, Carneiro F, Lindor NM, Edwards SL, French JD, Waddell N, Meltzer PS, Worthley DL, Schrader KA, Chenevix-Trench Get al., 2016, Point Mutations in Exon 1B of APC Reveal Gastric Adenocarcinoma and Proximal Polyposis of the Stomach as a Familial Adenomatous Polyposis Variant, AMERICAN JOURNAL OF HUMAN GENETICS, Vol: 98, Pages: 830-842, ISSN: 0002-9297

JOURNAL ARTICLE

Minh DC, Ganesamoorthy D, Cooper MA, Coin LJMet al., 2016, Realtime analysis and visualization of MinION sequencing data with npReader, BIOINFORMATICS, Vol: 32, Pages: 764-766, ISSN: 1367-4803

JOURNAL ARTICLE

Poznik GD, Xue Y, Mendez FL, Willems TF, Massaia A, Sayres MAW, Ayub Q, McCarthy SA, Narechania A, Kashin S, Chen Y, Banerjee R, Rodriguez-Flores JL, Cerezo M, Shao H, Gymrek M, Malhotra A, Louzada S, Desalle R, Ritchie GRS, Cerveira E, Fitzgerald TW, Garrison E, Marcketta A, Mittelman D, Romanovitch M, Zhang C, Zheng-Bradley X, Abecasis GR, McCarroll SA, Flicek P, Underhill PA, Coin L, Zerbino DR, Yang F, Lee C, Clarke L, Auton A, Erlich Y, Handsaker RE, Bustamante CD, Tyler-Smith Cet al., 2016, Punctuated bursts in human male demography inferred from 1,244 worldwide Y-chromosome sequences, NATURE GENETICS, Vol: 48, Pages: 593-+, ISSN: 1061-4036

JOURNAL ARTICLE

Altshuler DM, Durbin RM, Abecasis GR, Bentley DR, Chakravarti A, Clark AG, Donnelly P, Eichler EE, Flicek P, Gabriel SB, Gibbs RA, Green ED, Hurles ME, Knoppers BM, Korbel JO, Lander ES, Lee C, Lehrach H, Mardis ER, Marth GT, McVean GA, Nickerson DA, Schmidt JP, Sherry ST, Wang J, Wilson RK, Gibbs RA, Boerwinkle E, Doddapaneni H, Han Y, Korchina V, Kovar C, Lee S, Muzny D, Reid JG, Zhu Y, Wang J, Chang Y, Feng Q, Fang X, Guo X, Jian M, Jiang H, Jin X, Lan T, Li G, Li J, Li Y, Liu S, Liu X, Lu Y, Ma X, Tang M, Wang B, Wang G, Wu H, Wu R, Xu X, Yin Y, Zhang D, Zhang W, Zhao J, Zhao M, Zheng X, Lander ES, Altshuler DM, Gabriel SB, Gupta N, Gharani N, Toji LH, Gerry NP, Resch AM, Flicek P, Barker J, Clarke L, Gil L, Hunt SE, Kelman G, Kulesha E, Leinonen R, McLaren WM, Radhakrishnan R, Roa A, Smirnov D, Smith RE, Streeter I, Thormann A, Toneva I, Vaughan B, Zheng-Bradley X, Bentley DR, Grocock R, Humphray S, James T, Kingsbury Z, Lehrach H, Sudbrak R, Albrecht MW, Amstislavskiy VS, Borodina TA, Lienhard M, Mertes F, Sultan M, Timmermann B, Yaspo M-L, Mardis ER, Wilson RK, Fulton L, Fulton R, Sherry ST, Ananiev V, Belaia Z, Beloslyudtsev D, Bouk N, Chen C, Church D, Cohen R, Cook C, Garner J, Hefferon T, Kimelman M, Liu C, Lopez J, Meric P, O'Sullivan C, Ostapchuk Y, Phan L, Ponomarov S, Schneider V, Shekhtman E, Sirotkin K, Slotta D, Zhang H, McVean GA, Durbin RM, Balasubramaniam S, Burton J, Danecek P, Keane TM, Kolb-Kokocinski A, McCarthy S, Stalker J, Quail M, Schmidt JP, Davies CJ, Gollub J, Webster T, Wong B, Zhan Y, Auton A, Campbell CL, Kong Y, Marcketta A, Gibbs RA, Yu F, Antunes L, Bainbridge M, Muzny D, Sabo A, Huang Z, Wang J, Coin LJM, Fang L, Guo X, Jin X, Li G, Li Q, Li Y, Li Z, Lin H, Liu B, Luo R, Shao H, Xie Y, Ye C, Yu C, Zhang F, Zheng H, Zhu H, Alkan C, Dal E, Kahveci F, Marth GT, Garrison EP, Kural D, Lee W-P, Leong WF, Stromberg M, Ward AN, Wu J, Zhang M, Daly MJ, DePristo MA, Handsaker RE, Altshuler DM, Banks E, Bhatia G, del Angel G, Gabriel SBet al., 2015, A global reference for human genetic variation, NATURE, Vol: 526, Pages: 68-+, ISSN: 0028-0836

JOURNAL ARTICLE

Anderson ST, Kaforou M, Brent AJ, Wright VJ, Banwell CM, Chagaluka G, Crampin AC, Dockrell HM, French N, Hamilton MS, Hibberd ML, Kern F, Langford PR, Ling L, Mlotha R, Ottenhoff THM, Pienaar S, Pillay V, Scott JAG, Twahir H, Wilkinson RJ, Coin LJ, Heyderman RS, Levin M, Eley Bet al., 2014, Diagnosis of Childhood Tuberculosis and Host RNA Expression in Africa, NEW ENGLAND JOURNAL OF MEDICINE, Vol: 370, Pages: 1712-1723, ISSN: 0028-4793

JOURNAL ARTICLE

Bellos E, Coin LJM, 2014, cnvOffSeq: detecting intergenic copy number variation using off-target exome sequencing data, BIOINFORMATICS, Vol: 30, Pages: I639-I645, ISSN: 1367-4803

JOURNAL ARTICLE

Bellos E, Kumar V, Lin C, Maggi J, Phua ZY, Cheng C-Y, Cheung CMG, Hibberd ML, Wong TY, Coin LJM, Davila Set al., 2014, cnvCapSeq: detecting copy number variation in long-range targeted resequencing data, NUCLEIC ACIDS RESEARCH, Vol: 42, ISSN: 0305-1048

JOURNAL ARTICLE

Ramasamy A, Trabzuni D, Guelfi S, Varghese V, Smith C, Walker R, De T, Coin L, de Silva R, Cookson MR, Singleton AB, Hardy J, Ryten M, Weale MEet al., 2014, Genetic variability in the regulation of gene expression in ten regions of the human brain, NATURE NEUROSCIENCE, Vol: 17, Pages: 1418-1428, ISSN: 1097-6256

JOURNAL ARTICLE

White HD, Held C, Stewart R, Tarka E, Brown R, Davies RY, Budaj A, Harrington RA, Steg PG, Ardis-Sino D, Armstrong PW, Avezum A, Aylward PE, Bryce A, Chen H, Chen M-F, Corbalan R, Dalby AJ, Danchin N, De Winter RJ, Denchev S, Diaz R, Elisaf M, Flather MD, Goudev AR, Granger CB, Grinfeld L, Hochman JS, Husted S, Kim H-S, Koenig W, Linhart A, Lonn E, Lopez-Sendon J, Manolis AJ, Mohler ER, Nicolau JC, Pais P, Parkhomenko A, Pedersen TR, Pella D, Ramos-Corrales MA, Ruda M, Sereg M, Siddique S, Sinnaeve P, Smith P, Sritara P, Swart HP, Sy RG, Teramoto T, Tse H-F, Watson D, Weaver WD, Weiss R, Viigimaa M, Vinereanu D, Zhu J, Cannon CP, Wallentin Let al., 2014, Darapladib for Preventing Ischemic Events in Stable Coronary Heart Disease, NEW ENGLAND JOURNAL OF MEDICINE, Vol: 370, Pages: 1702-1711, ISSN: 0028-4793

JOURNAL ARTICLE

Alves AC, Bruhn S, Ramasamy A, Wang H, Holloway JW, Hartikainen A-L, Jarvelin M-R, Benson M, Balding DJ, Coin LJMet al., 2013, Dysregulation of Complement System and CD4+T Cell Activation Pathways Implicated in Allergic Response, PLOS ONE, Vol: 8, ISSN: 1932-6203

JOURNAL ARTICLE

Bonnelykke K, Matheson MC, Pers TH, Granell R, Strachan DP, Alves AC, Linneberg A, Curtin JA, Warrington NM, Standl M, Kerkhof M, Jonsdottir I, Bukvic BK, Kaakinen M, Sleimann P, Thorleifsson G, Thorsteinsdottir U, Schramm K, Baltic S, Kreiner-Moller E, Simpson A, St Pourcain B, Coin L, Hui J, Walters EH, Tiesler CMT, Duffy DL, Jones G, Ring SM, McArdle WL, Price L, Robertson CF, Pekkanen J, Tang CS, Thiering E, Montgomery GW, Hartikainen A-L, Dharmage SC, Husemoen LL, Herder C, Kemp JP, Elliot P, James A, Waldenberger M, Abramson MJ, Fairfax BP, Knight JC, Gupta R, Thompson PJ, Holt P, Sly P, Hirschhorn JN, Blekic M, Weidinger S, Hakonarsson H, Stefansson K, Heinrich J, Postma DS, Custovic A, Pennell CE, Jarvelin M-R, Koppelman GH, Timpson N, Ferreira MA, Bisgaard H, Henderson AJet al., 2013, Meta-analysis of genome-wide association studies identifies ten loci influencing allergic sensitization, NATURE GENETICS, Vol: 45, Pages: 902-U290, ISSN: 1061-4036

JOURNAL ARTICLE

Couto-Alves A, Wright VJ, Perumal K, Binder A, Carrol ED, Emonts M, de Groot R, Hazelzet J, Kuijpers T, Nadel S, Zenz W, Ramnarayan P, Levin M, Coin L, Inwald DPet al., 2013, A new scoring system derived from base excess and platelet count at presentation predicts mortality in paediatric meningococcal sepsis, CRITICAL CARE, Vol: 17, ISSN: 1466-609X

JOURNAL ARTICLE

Ikram MA, Fornage M, Smith AV, Seshadri S, Schmidt R, Debette S, Vrooman HA, Sigurdsson S, Ropele S, Taal HR, Mook-Kanamori DO, Coker LH, Longstreth WT, Niessen WJ, DeStefano AL, Beiser A, Zijdenbos AP, Struchalin M, Jack CR, Rivadeneira F, Uitterlinden AG, Knopman DS, Hartikainen A-L, Pennell CE, Thiering E, Steegers EAP, Hakonarson H, Heinrich J, Palmer LJ, Jarvelin M-R, McCarthy MI, Grant SFA, St Pourcain B, Timpson NJ, Smith GD, Sovio U, Nalls MA, Au R, Hofman A, Gudnason H, van der Lugt A, Harris TB, Meeks WM, Vernooij MW, van Buchem MA, Catellier D, Jaddoe VWV, Gudnason V, Windham BG, Wolf PA, van Duijn CM, Mosley TH, Schmidt H, Launer LJ, Breteler MMB, DeCarli Cet al., 2013, Common variants at 6q22 and 17q21 are associated with intracranial volume (vol 44, pg 539, 2012), NATURE GENETICS, Vol: 45, Pages: 713-713, ISSN: 1061-4036

JOURNAL ARTICLE

Kaforou M, Wright VJ, Oni T, French N, Anderson ST, Bangani N, Banwell C, Brent AJ, Crampin AC, Dockrell HM, Eley B, Heyderman RS, Hibberd ML, Kern F, Langford PR, Ling L, Mendelson M, Ottenhoff TH, Zgambo F, Wilkinson RJ, Coin LJ, Levin Met al., 2013, Detection of Tuberculosis in HIV-Infected and -Uninfected African Adults Using Whole Blood RNA Expression Signatures: A Case-Control Study, PLOS MEDICINE, Vol: 10, ISSN: 1549-1676

JOURNAL ARTICLE

Levin M, Kaforou M, Herberg J, Wright VJ, Coin LJMet al., 2013, METHOD FOR CALCULATING A DISEASE RISK SCORE, PCT/GB2013/050225

The present disclosure relates to a general method for converting complex gene expression data into a simple, composite disease risk score which can be used for the development of rapid diagnostic tests suitable for clinical use for the determination of the presence of an infection or disease in a host.

PATENT

Munhoz RP, Teive HA, Eleftherohorinou H, Coin LJ, Lees AJ, Silveira-Moriyama Let al., 2013, Demographic and motor features associated with the occurrence of neuropsychiatric and sleep complications of Parkinson's disease, JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY, Vol: 84, Pages: 883-887, ISSN: 0022-3050

JOURNAL ARTICLE

Shao H, Bellos E, Yin H, Liu X, Zou J, Li Y, Wang J, Coin LJMet al., 2013, A population model for genotyping indels from next-generation sequence data, NUCLEIC ACIDS RESEARCH, Vol: 41, ISSN: 0305-1048

JOURNAL ARTICLE

Taal HR, St Pourcain B, Thiering E, Das S, Mook-Kanamori DO, Warrington NM, Kaakinen M, Kreiner-Moller E, Bradfield JP, Freathy RM, Geller F, Guxens M, Cousminer DL, Kerkhof M, Timpson NJ, Ikram MA, Beilin LJ, Bonnelykke K, Buxton JL, Charoen P, Chawes BLK, Eriksson J, Evans DM, Hofman A, Kemp JP, EKim C, Klopp N, Lahti J, Lye SJ, McMahon G, Mentch FD, Mueller-Nurasyid M, O'Reilly PF, Prokopenko I, Rivadeneira F, Steegers EAP, Sunyer J, Tiesler C, Yaghootkar H, Breteler MMB, Debette S, Fornage M, Gudnason V, Launer LJ, van der Lugt A, Mosley TH, Seshadri S, Smith AV, Vernooij MW, Blakemore AIF, Chiavacci RM, Feenstra B, Fernandez-Banet J, Grant SFA, Hartikainen A-L, van der Heijden AJ, Iniguez C, Lathrop M, McArdle WL, Molgaard A, Newnham JP, Palmer LJ, Palotie A, Pouta A, Ring SM, Sovio U, Standl M, Uitterlinden AG, Wichmann H-E, Vissing NH, DeCarli C, van Duijn CM, McCarthy MI, Koppelman GH, Estivill X, Hattersley AT, Melbye M, Bisgaard H, Pennell CE, Widen E, Hakonarson H, Smith GD, Heinrich J, Jarvelin M-R, Jaddoe VWVet al., 2013, Common variants at 12q15 and 12q24 are associated with infant head circumference (vol 44, pg 532, 2012), NATURE GENETICS, Vol: 45, Pages: 713-713, ISSN: 1061-4036

JOURNAL ARTICLE

Walters RG, Coin LJM, Ruokonen A, de Smith AJ, Moustafa JSE-S, Jacquemont S, Elliott P, Esko T, Hartikainen A-L, Laitinen J, Maennik K, Martinet D, Meyre D, Nauck M, Schurmann C, Sladek R, Thorleifsson G, Thorsteinsdottir U, Valsesia A, Waeber G, Zufferey F, Balkau B, Pattou F, Metspalu A, Voelzke H, Vollenweider P, Stefansson K, Jarvelin M-R, Beckmann JS, Froguel P, Blakemore AIFet al., 2013, Rare Genomic Structural Variants in Complex Disease: Lessons from the Replication of Associations with Obesity, PLOS ONE, Vol: 8, ISSN: 1932-6203

JOURNAL ARTICLE

Zhang F, Chen R, Liu D, Yao X, Li G, Jin Y, Yu C, Li Y, Coin LJMet al., 2013, YHap: a population model for probabilistic assignment of Y haplogroups from re-sequencing data, BMC BIOINFORMATICS, Vol: 14, ISSN: 1471-2105

JOURNAL ARTICLE

al Basatena N-KS, Hoggart CJ, Coin LJ, O'Reilly PFet al., 2013, The Effect of Genomic Inversions on Estimation of Population Genetic Parameters from SNP Data, GENETICS, Vol: 193, Pages: 243-253, ISSN: 0016-6731

JOURNAL ARTICLE

Barrenas F, Chavali S, Alves AC, Coin L, Jarvelin M-R, Jornsten R, Langston MA, Ramasamy A, Rogers G, Wang H, Benson Met al., 2012, Highly interconnected genes in disease-specific networks are enriched for disease-associated polymorphisms, GENOME BIOLOGY, Vol: 13, ISSN: 1474-7596

JOURNAL ARTICLE

Bellos E, Coin LJM, Kaforou M, 2012, Bioinformatics: living on the edge, GENOME BIOLOGY, Vol: 13, ISSN: 1465-6906

JOURNAL ARTICLE

Bellos E, Johnson MR, Coin LJM, 2012, cnvHiTSeq: integrative models for high-resolution copy number variation detection and genotyping using population sequencing data, GENOME BIOLOGY, Vol: 13, ISSN: 1474-7596

JOURNAL ARTICLE

Coin LJM, Cao D, Ren J, Zuo X, Sun L, Yang S, Zhang X, Cui Y, Li Y, Jin X, Wang Jet al., 2012, An exome sequencing pipeline for identifying and genotyping common CNVs associated with disease with application to psoriasis, BIOINFORMATICS, Vol: 28, Pages: I370-I374, ISSN: 1367-4803

JOURNAL ARTICLE

Costelloe SJ, Moustafa JSE-S, Drenos F, Palmen J, Qiao L, Whiting S, Thomas M, Kivimaki M, Kumari M, Hingorani AD, Tzoulaki I, Marjo-Riitta J, Aimo R, Hartikainen A-L, Pouta A, Walters RG, Blakemore AIF, Humphries SE, Coin LJM, Talmud PJet al., 2012, Gene-Targeted Analysis of Copy Number Variants Identifies 3 Novel Associations With Coronary Heart Disease Traits, CIRCULATION-CARDIOVASCULAR GENETICS, Vol: 5, Pages: 555-560, ISSN: 1942-325X

JOURNAL ARTICLE

Dastani Z, Hivert M-F, Timpson N, Perry JRB, Yuan X, Scott RA, Henneman P, Heid IM, Kizer JR, Lyytikainen L-P, Fuchsberger C, Tanaka T, Morris AP, Small K, Isaacs A, Beekman M, Coassin S, Lohman K, Qi L, Kanoni S, Pankow JS, Uh H-W, Wu Y, Bidulescu A, Rasmussen-Torvik LJ, Greenwood CMT, Ladouceur M, Grimsby J, Manning AK, Liu C-T, Kooner J, Mooser VE, Vollenweider P, Kapur KA, Chambers J, Wareham NJ, Langenberg C, Frants R, Willems-vanDijk K, Oostra BA, Willems SM, Lamina C, Winkler TW, Psaty BM, Tracy RP, Brody J, Chen I, Viikari J, Kahonen M, Pramstaller PP, Evans DM, St Pourcain B, Sattar N, Wood AR, Bandinelli S, Carlson OD, Egan JM, Bohringer S, van Heemst D, Kedenko L, Kristiansson K, Nuotio M-L, Loo B-M, Harris T, Garcia M, Kanaya A, Haun M, Klopp N, Wichmann H-E, Deloukas P, Katsareli E, Couper DJ, Duncan BB, Kloppenburg M, Adair LS, Borja JB, Wilson JG, Musani S, Guo X, Johnson T, Semple R, Teslovich TM, Allison MA, Redline S, Buxbaum SG, Mohlke KL, Meulenbelt I, Ballantyne CM, Dedoussis GV, Hu FB, Liu Y, Paulweber B, Spector TD, Slagboom PE, Ferrucci L, Jula A, Perola M, Raitakari O, Florez JC, Salomaa V, Eriksson JG, Frayling TM, Hicks AA, Lehtimaki T, Smith GD, Siscovick DS, Kronenberg F, van Duijn C, Loos RJF, Waterworth DM, Meigs JB, Dupuis J, Richards JBet al., 2012, Novel Loci for Adiponectin Levels and Their Influence on Type 2 Diabetes and Metabolic Traits: A Multi-Ethnic Meta-Analysis of 45,891 Individuals, PLOS GENETICS, Vol: 8, ISSN: 1553-7404

JOURNAL ARTICLE

Hoggart CJ, O'Reilly PF, Kaakinen M, Zhang W, Chambers JC, Kooner JS, Coin LJM, Jarvelin M-Ret al., 2012, Fine-Scale Estimation of Location of Birth from Genome-Wide Single-Nucleotide Polymorphism Data, GENETICS, Vol: 190, Pages: 669-U583, ISSN: 0016-6731

JOURNAL ARTICLE

Moustafa JSE-S, Eleftherohorinou H, de Smith AJ, Andersson-Assarsson JC, Alves AC, Hadjigeorgiou E, Walters RG, Asher JE, Bottolo L, Buxton JL, Sladek R, Meyre D, Dina C, Visvikis-Siest S, Jacobson P, Sjostrom L, Carlsson LMS, Walley A, Falchi M, Froguel P, Blakemore AIF, Coin LJMet al., 2012, Novel association approach for variable number tandem repeats (VNTRs) identifies DOCK5 as a susceptibility gene for severe obesity, HUMAN MOLECULAR GENETICS, Vol: 21, Pages: 3727-3738, ISSN: 0964-6906

JOURNAL ARTICLE

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