Imperial College London
Alternate

DrLachlanCoin

Faculty of Medicine, Department of Infectious Disease

Honorary Senior Lecturer
 
 
 
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Contact

 

+44 (0)20 7594 1930l.coin

 
 
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Location

 

172Medical SchoolSt Mary's Campus

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Summary

 

Publications

Citation

BibTex format

@article{Poznik:2016:10.1038/ng.3559,
author = {Poznik, GD and Xue, Y and Mendez, FL and Willems, TF and Massaia, A and Wilson, Sayres MA and Ayub, Q and McCarthy, SA and Narechania, A and Kashin, S and Chen, Y and Banerjee, R and Rodriguez-Flores, JL and Cerezo, M and Shao, H and Gymrek, M and Malhotra, A and Louzada, S and Desalle, R and Ritchie, GR and Cerveira, E and Fitzgerald, TW and Garrison, E and Marcketta, A and Mittelman, D and Romanovitch, M and Zhang, C and Zheng-Bradley, X and Abecasis, GR and McCarroll, SA and Flicek, P and Underhill, PA and Coin, L and Zerbino, DR and Yang, F and Lee, C and Clarke, L and Auton, A and Erlich, Y and Handsaker, RE and 1000, Genomes Project Consortium and Bustamante, CD and Tyler-Smith, C},
doi = {10.1038/ng.3559},
journal = {Nature Genetics},
pages = {593--599},
title = {Punctuated bursts in human male demography inferred from 1,244 worldwide Y-chromosome sequences},
url = {http://dx.doi.org/10.1038/ng.3559},
volume = {48},
year = {2016}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - We report the sequences of 1,244 human Y chromosomes randomly ascertained from 26 worldwide populations by the 1000 Genomes Project. We discovered more than 65,000 variants, including single-nucleotide variants, multiple-nucleotide variants, insertions and deletions, short tandem repeats, and copy number variants. Of these, copy number variants contribute the greatest predicted functional impact. We constructed a calibrated phylogenetic tree on the basis of binary single-nucleotide variants and projected the more complex variants onto it, estimating the number of mutations for each class. Our phylogeny shows bursts of extreme expansion in male numbers that have occurred independently among each of the five continental superpopulations examined, at times of known migrations and technological innovations.
AU  - Poznik,GD
AU  - Xue,Y
AU  - Mendez,FL
AU  - Willems,TF
AU  - Massaia,A
AU  - Wilson,Sayres MA
AU  - Ayub,Q
AU  - McCarthy,SA
AU  - Narechania,A
AU  - Kashin,S
AU  - Chen,Y
AU  - Banerjee,R
AU  - Rodriguez-Flores,JL
AU  - Cerezo,M
AU  - Shao,H
AU  - Gymrek,M
AU  - Malhotra,A
AU  - Louzada,S
AU  - Desalle,R
AU  - Ritchie,GR
AU  - Cerveira,E
AU  - Fitzgerald,TW
AU  - Garrison,E
AU  - Marcketta,A
AU  - Mittelman,D
AU  - Romanovitch,M
AU  - Zhang,C
AU  - Zheng-Bradley,X
AU  - Abecasis,GR
AU  - McCarroll,SA
AU  - Flicek,P
AU  - Underhill,PA
AU  - Coin,L
AU  - Zerbino,DR
AU  - Yang,F
AU  - Lee,C
AU  - Clarke,L
AU  - Auton,A
AU  - Erlich,Y
AU  - Handsaker,RE
AU  - 1000,Genomes Project Consortium
AU  - Bustamante,CD
AU  - Tyler-Smith,C
DO  - 10.1038/ng.3559
EP  - 599
PY  - 2016///
SN  - 1546-1718
SP  - 593
TI  - Punctuated bursts in human male demography inferred from 1,244 worldwide Y-chromosome sequences
T2  - Nature Genetics
UR  - http://dx.doi.org/10.1038/ng.3559
UR  - http://hdl.handle.net/10044/1/34198
VL  - 48
ER  -
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