Imperial College London

DrLorenzoDi Michele

Faculty of Natural SciencesDepartment of Chemistry

Senior Lecturer



+44 (0)20 7594 3262l.di-michele Website




Molecular Sciences Research HubWhite City Campus





Biomimetic Soft Matter and DNA Nanotechnology

Group website:

Lorenzo Di Michele's group studies the fascinating physics, chemistry, and (occasionally) biology of complex nanoscale systems.

We investigate problems of fundamental relevance as well as develop new technologies and, to do so, we often make use of the tools of DNA nanotechnology.

We like to adopt a multidisciplinary approach, that combines experimental methods, theoretical modelling, and computer simulations.  

Current areas of research include

- Self assembly and crystallisation of amphiphilic DNA nanostructures, with applications to encapsulation/release/delivery technologies.

- Multivalent membrane-membrane and membrane particles interactions, including synthetic lipid membranes and cells.

- Artificial cells and bottom-up synthetic biology.

- Applications of DNA nanotech to super-resolution optical microscopy (DNA-PAINT).

Lorenzo's brief CV

Lorenzo completed his undergraduate and master degree at the University of L'Aquila (Abruzzo, Italy), before moving to the Cavendish Laboratory, University of Cambridge where he complete his PhD in physics (2013). He then held, in the same institution, a Oppenheimer Early Career Research Fellowship (2013-2016), a Leverhulme Early Career Research Fellowship (2016-2017) and a Royal Society University Research Fellowship (2018 - ). In August 2019 Lorenzo joined the Department of Chemistry at Imperial as a RS URF and Lecturer.

Full CV here



Rubio-Sánchez R, O'Flaherty DK, Wang A, et al., 2021, Thermally Driven Membrane Phase Transitions Enable Content Reshuffling in Primitive Cells., J Am Chem Soc

Walczak M, Brady RA, Mancini L, et al., 2021, Responsive core-shell DNA particles trigger lipid-membrane disruption and bacteria entrapment, Nature Communications, Vol:12, ISSN:2041-1723, Pages:1-11

Morzy D, Rubio-Sanchez R, Joshi H, et al., 2021, Cations Regulate Membrane Attachment and Functionality of DNA Nanostructures, Journal of the American Chemical Society, Vol:143, ISSN:0002-7863, Pages:7358-7367

Rubio R, Eizagirre Barker S, Walczak M, et al., 2021, A modular, dynamic, DNA-based platform for regulating cargo distribution and transport between lipid domains, Nano Letters, Vol:21, ISSN:1530-6984, Pages:2800-2808

Clowsley AH, Kaufhold WT, Lutz T, et al., 2021, Repeat DNA-PAINT suppresses background and non-specific signals in optical nanoscopy, Nature Communications, Vol:12, ISSN:2041-1723

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