Imperial College London

DrLorenzoDi Michele

Faculty of Natural SciencesDepartment of Chemistry

Research Fellow (Royal Society URF)
 
 
 
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Contact

 

+44 (0)20 7594 3262l.di-michele Website

 
 
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Location

 

Molecular Sciences Research HubWhite City Campus

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Summary

 

Publications

Publication Type
Year
to

37 results found

del Barrio J, Liu J, Brady RA, Tan CSY, Chiodini S, Ricci M, Fernandez-Leiro R, Tsai C-J, Vasileiadi P, Di Michele L, Lairez D, Toprakcioglu C, Scherman OAet al., 2019, Emerging Two-Dimensional Crystallization of Cucurbit[8]uril Complexes: From Supramolecular Polymers to Nanofibers, JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, Vol: 141, Pages: 14021-14025, ISSN: 0002-7863

Journal article

Mognetti BM, Cicuta P, Di Michele L, Programmable interactions with biomimetic DNA linkers at fluid membranes and interfaces., Rep Prog Phys

At the heart of the structured architecture and complex dynamics of biological
 systems are specific and timely interactions operated by biomolecules. In many
 instances, biomolecular agents are spatially confined to flexible lipid membranes where,
 among other functions, they control cell adhesion, motility and tissue formation.
 Besides being central to several biological processes, multivalent interactions mediated
 by reactive linkers confined to deformable substrates underpin the design of synthetic-
 biological platforms and advanced biomimetic materials. Here we review recent
 advances on the experimental study and theoretical modelling of a heterogeneous
 class of biomimetic systems in which synthetic linkers mediate multivalent interactions
 between fluid and deformable colloidal units, including lipid vesicles and emulsion
 droplets. Linkers are often prepared from synthetic DNA nanostructures, enabling
 full programmability of the thermodynamic and kinetic properties of their mutual
 interactions. The coupling of the statistical effects of multivalent interactions with
 substrate fluidity and deformability gives rise to a rich emerging phenomenology that,
 in the context of self-assembled soft materials, has been shown to produce exotic phase
 behaviour, stimuli-responsiveness, and kinetic programmability of the self-assembly
 process. Applications to (synthetic) biology will also be reviewed.

Journal article

Kaufhold WT, Brady RA, Tuffnell JM, Cicuta P, Di Michele Let al., 2019, Membrane Scaffolds Enhance the Responsiveness and Stability of DNA-Based Sensing Circuits, BIOCONJUGATE CHEMISTRY, Vol: 30, Pages: 1850-1859, ISSN: 1043-1802

Journal article

Talbot EL, Kotar J, Di Michele L, Cicuta Pet al., 2019, Directed tubule growth from giant unilamellar vesicles in a thermal gradient, SOFT MATTER, Vol: 15, Pages: 1676-1683, ISSN: 1744-683X

Journal article

Lanfranco R, Jana PK, Tunesi L, Cicuta P, Mognetti BM, Di Michele L, Bruylants Get al., 2019, Kinetics of Nanoparticle-Membrane Adhesion Mediated by Multivalent Interactions, LANGMUIR, Vol: 35, Pages: 2002-2012, ISSN: 0743-7463

Journal article

Brady RA, Kaufhold WT, Brooks NJ, Fodera V, Di Michele Let al., 2019, Flexibility defines structure in crystals of amphiphilic DNA nanostars, JOURNAL OF PHYSICS-CONDENSED MATTER, Vol: 31, ISSN: 0953-8984

Journal article

Brady RA, Brooks NJ, Foderà V, Cicuta P, Di Michele Let al., 2018, Amphiphilic-DNA platform for the design of crystalline frameworks with programmable structure and functionality, Journal of the American Chemical Society, Vol: 140, Pages: 15384-15392, ISSN: 1520-5126

The reliable preparation of functional, ordered, nanostructured frameworks would be a game changer for many emerging technologies, from energy storage to nanomedicine. Underpinned by the excellent molecular recognition of nucleic acids, along with their facile synthesis and breadth of available functionalizations, DNA nanotechnology is widely acknowledged as a prime route for the rational design of nanostructured materials. Yet, the preparation of crystalline DNA frameworks with programmable structure and functionality remains a challenge. Here we demonstrate the potential of simple amphiphilic DNA motifs, dubbed "C-stars", as a versatile platform for the design of programmable DNA crystals. In contrast to all-DNA materials, in which structure depends on the precise molecular details of individual building blocks, the self-assembly of C-stars is controlled uniquely by their topology and symmetry. Exploiting this robust self-assembly principle, we design a range of topologically identical, but structurally and chemically distinct C-stars that following a one-pot reaction self-assemble into highly porous, functional, crystalline frameworks. Simple design variations allow us to fine-tune the lattice parameter and thus control the partitioning of macromolecules within the frameworks, embed responsive motifs that can induce isothermal disassembly, and include chemical moieties to capture target proteins specifically and reversibly.

Journal article

Di Michele L, Jana PK, Mognetti BM, 2018, Steric interactions between mobile ligands facilitate complete wrapping in passive endocytosis, PHYSICAL REVIEW E, Vol: 98, ISSN: 2470-0045

Journal article

Jayasinghe ID, Clowsley AH, Lin R, Lutz T, Harrison C, Green EM, Baddeley D, Di Michele L, Soeller Cet al., 2018, Molecular Scale Visualisation of Variable Clustering Properties of the Cardiac Ryanodine Receptor, 62nd Annual Meeting of the Biophysical-Society, Publisher: CELL PRESS, Pages: 118A-118A, ISSN: 0006-3495

Conference paper

Lutz T, Clowsley AH, Lin R, Pagliara S, di Michele L, Soeller Cet al., 2018, Versatile Multiplexed Super-Resolution Imaging of Nanostructures by Quencher-Exchange-Paint, 62nd Annual Meeting of the Biophysical-Society, Publisher: CELL PRESS, Pages: 349A-349A, ISSN: 0006-3495

Conference paper

Jayasinghe I, Clowsley AH, Lin R, Lutz T, Harrison C, Green E, Baddeley D, Di Michele L, Soeller Cet al., 2018, True Molecular Scale Visualization of Variable Clustering Properties of Ryanodine Receptors, CELL REPORTS, Vol: 22, Pages: 557-567, ISSN: 2211-1247

Journal article

Borro BC, Parolini L, Cicuta P, Fodera V, Di Michele Let al., 2017, Interaction with prefibrillar species and amyloid-like fibrils changes the stiffness of lipid bilayers, PHYSICAL CHEMISTRY CHEMICAL PHYSICS, Vol: 19, Pages: 27930-27934, ISSN: 1463-9076

Journal article

Rautu SA, Orsi D, Di Michele L, Rowlands G, Cicuta P, Turner MSet al., 2017, The role of optical projection in the analysis of membrane fluctuations, SOFT MATTER, Vol: 13, Pages: 3480-3483, ISSN: 1744-683X

Journal article

Talbot EL, Kotar J, Parolini L, Di Michele L, Cicuta Pet al., 2017, Thermophoretic migration of vesicles depends on mean temperature and head group chemistry, NATURE COMMUNICATIONS, Vol: 8, ISSN: 2041-1723

Journal article

Brady R, Brooks NJ, Cicuta P, Di Michele Let al., 2017, Crystallization of amphiphilic DNA C-Stars, Nano Letters, Vol: 17, Pages: 3276-3281, ISSN: 1530-6992

Many emerging technologies require materials with well-defined 3D nanoscale architectures. Production of these structures is currently underpinned by self-assembling amphiphilic macromolecules or engineered all-DNA building blocks. Both these approaches produce restricted ranges of crystal geometries due to synthetic amphiphiles’ simple shape and limited specificity, or the technical difficulties in designing space-filling DNA motifs with targeted shapes. We have overcome these limitations with amphiphilic DNA-nanostructures, or “C-Stars”, that combine the design freedom and facile functionalization of DNA-based materials with robust hydrophobic interactions. C-Stars self-assemble into single crystals exceeding 40 μm in size with lattice parameters exceeding 20 nm.

Journal article

Amjad OA, Mognetti BM, Cicuta P, Di Michele Let al., 2017, Membrane Adhesion through Bridging by Multimeric Ligands, LANGMUIR, Vol: 33, Pages: 1139-1146, ISSN: 0743-7463

Journal article

Talbot EL, Parolini L, Kotar J, Di Michele L, Cicuta Pet al., 2017, Thermal-driven domain and cargo transport in lipid membranes, PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, Vol: 114, Pages: 846-851, ISSN: 0027-8424

Journal article

Jayasinghe I, Clowsley A, Lutz T, Green E, Lin R, di Michele L, Soeller Cet al., 2016, TRUE MOLECULAR SCALE ANALYSIS OF THE CALCIUM RELEASE MACHINERY OF THE HEART WITH ENHANCED SUPER-RESOLUTION IMAGING, Autumn Meeting of the British-Society-for-Cardiovascular-Research (BSCR), Publisher: BMJ PUBLISHING GROUP, Pages: A2-A3, ISSN: 1355-6037

Conference paper

Di Michele L, Bachmann SJ, Parolini L, Mognetti BMet al., 2016, Communication: Free energy of ligand-receptor systems forming multimeric complexes, JOURNAL OF CHEMICAL PHYSICS, Vol: 144, ISSN: 0021-9606

Journal article

Talbot E, Parolini L, Kotar J, Di Michele L, Cicuta Pet al., 2016, Migration of Vesicles and their Domains in a Thermal Gradient, 60th Annual Meeting of the Biophysical-Society, Publisher: CELL PRESS, Pages: 70A-70A, ISSN: 0006-3495

Conference paper

Parolini L, Kotar J, Di Michele L, Mognetti BMet al., 2016, Controlling Self-Assembly Kinetics of DNA-Functionalized Liposomes Using Toehold Exchange Mechanism, ACS NANO, Vol: 10, Pages: 2392-2398, ISSN: 1936-0851

Journal article

Bachmann SJ, Kotar J, Parolini L, Saric A, Cicuta P, Di Michele L, Mognetti BMet al., 2016, Melting transition in lipid vesicles functionalised by mobile DNA linkers, SOFT MATTER, Vol: 12, Pages: 7804-7817, ISSN: 1744-683X

Journal article

Zaccone A, Terentjev I, Di Michele L, Terentjev EMet al., 2015, Fragmentation and depolymerization of non-covalently bonded filaments, JOURNAL OF CHEMICAL PHYSICS, Vol: 142, ISSN: 0021-9606

Journal article

Shimobayashi SF, Mognetti BM, Parolini L, Orsi D, Cicuta P, Di Michele Let al., 2015, Direct measurement of DNA-mediated adhesion between lipid bilayers, PHYSICAL CHEMISTRY CHEMICAL PHYSICS, Vol: 17, Pages: 15615-15628, ISSN: 1463-9076

Journal article

Parolini L, Mognetti BM, Kotar J, Eiser E, Cicuta P, Di Michele Let al., 2015, Volume and porosity thermal regulation in lipid mesophases by coupling mobile ligands to soft membranes, NATURE COMMUNICATIONS, Vol: 6, ISSN: 2041-1723

Journal article

Di Michele L, Mognetti BM, Yanagishima T, Varilly P, Ruff Z, Frenkel D, Eiser Eet al., 2014, Effect of Inert Tails on the Thermodynamics of DNA Hybridization, JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, Vol: 136, Pages: 6538-6541, ISSN: 0002-7863

Journal article

Di Michele L, Fiocco D, Varrato F, Sastry S, Eiser E, Foffi Get al., 2014, Aggregation dynamics, structure, and mechanical properties of bigels, SOFT MATTER, Vol: 10, Pages: 3633-3648, ISSN: 1744-683X

Journal article

Di Michele L, Eiser E, Fodera V, 2013, Minimal Model for Self-Catalysis in the Formation of Amyloid-Like Elongated Fibrils, JOURNAL OF PHYSICAL CHEMISTRY LETTERS, Vol: 4, Pages: 3158-3164, ISSN: 1948-7185

Journal article

Di Michele L, Varrato F, Kotar J, Nathan SH, Foffi G, Eiser Eet al., 2013, Multistep kinetic self-assembly of DNA-coated colloids, NATURE COMMUNICATIONS, Vol: 4, ISSN: 2041-1723

Journal article

Di Michele L, Eiser E, 2013, Developments in understanding and controlling self assembly of DNA-functionalized colloids, PHYSICAL CHEMISTRY CHEMICAL PHYSICS, Vol: 15, Pages: 3115-3129, ISSN: 1463-9076

Journal article

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