Imperial College London
Portrait Picture

DrLorenzoDi Michele

Faculty of Natural Sciences, Department of Chemistry

Honorary Senior Lecturer
 
 
 
//

Contact

 

+44 (0)20 7594 3262l.di-michele Website

 
 
//

Location

 

Molecular Sciences Research HubWhite City Campus

//

Summary

 

Publications

Citation

BibTex format

@article{Mognetti:2019:1361-6633/ab37ca,
author = {Mognetti, BM and Cicuta, P and Di, Michele L},
doi = {1361-6633/ab37ca},
journal = {Reports on Progress in Physics},
pages = {1--34},
title = {Programmable interactions with biomimetic DNA linkers at fluid membranes and interfaces.},
url = {http://dx.doi.org/10.1088/1361-6633/ab37ca},
volume = {82},
year = {2019}
}
Download

RIS format (EndNote, RefMan)

TY  - JOUR
AB  - At the heart of the structured architecture and complex dynamics of biological
 systems are specic and timely interactions operated by biomolecules. In many
 instances, biomolecular agents are spatially conned to exible lipid membranes where,
 among other functions, they control cell adhesion, motility and tissue formation.
 Besides being central to several biological processes, multivalent interactions mediated
 by reactive linkers conned to deformable substrates underpin the design of synthetic-
 biological platforms and advanced biomimetic materials. Here we review recent
 advances on the experimental study and theoretical modelling of a heterogeneous
 class of biomimetic systems in which synthetic linkers mediate multivalent interactions
 between uid and deformable colloidal units, including lipid vesicles and emulsion
 droplets. Linkers are often prepared from synthetic DNA nanostructures, enabling
 full programmability of the thermodynamic and kinetic properties of their mutual
 interactions. The coupling of the statistical eects of multivalent interactions with
 substrate uidity and deformability gives rise to a rich emerging phenomenology that,
 in the context of self-assembled soft materials, has been shown to produce exotic phase
 behaviour, stimuli-responsiveness, and kinetic programmability of the self-assembly
 process. Applications to (synthetic) biology will also be reviewed.
AU  - Mognetti,BM
AU  - Cicuta,P
AU  - Di,Michele L
DO  - 1361-6633/ab37ca
EP  - 34
PY  - 2019///
SN  - 0034-4885
SP  - 1
TI  - Programmable interactions with biomimetic DNA linkers at fluid membranes and interfaces.
T2  - Reports on Progress in Physics
UR  - http://dx.doi.org/10.1088/1361-6633/ab37ca
UR  - https://www.ncbi.nlm.nih.gov/pubmed/31370052
UR  - https://iopscience.iop.org/article/10.1088/1361-6633/ab37ca
VL  - 82
ER  -
Download