Imperial College London


Faculty of MedicineNational Heart & Lung Institute

Professor of Respiratory Cell Biology



+44 (0)20 7594 7895l.donnelly




G227AGuy Scadding BuildingRoyal Brompton Campus





Louise Donnelly is Professor of Respiratory Cell Biology, within the Section of Airway Disease at the NHLI. She obtained her BSc in Biochemistry from the University of Bath and subsequently a PhD in Biochemistry from the University of Cardiff. This was followed by a post-doctoral position in cell signaling at the Royal Postgraduate Medical School (now part of Imperial College London) prior to working at the NHLI.

Since 1995, Professor Donnelly has worked in the field of respiratory cell biology with a particular interest in the cellular profile in inflammatory lung diseases including asthma and COPD. Her research has focussed upon how inflammatory cells are altered in the disease state and the investigation of novel therapeutic strategies. To this end, she has established a number of human primary cell systems to investigate mechanisms of aberrant inflammation. She has published extensively and has presented both nationally and internationally as well as acting as an editor for  Current Respiratory Medicine Reviews.

Professor Donnelly is currently Director of the Respiratory Science BSc and is involved in respiratory teaching on  the undergraduate MBSS course. In 2009, Professor Donnelly received a Rector's Award for Research Supervision and in 2012 a Rector's Award for Pastoral Care.

Professor Donnelly has been a member of the British Association of Lung Research (BALR) committee for several years and is the current chair of the BALR.  She is currently a member of the British Lung Foundation Scientific Committee and the European Respiratory Society Evaluation Committee



Bewley M, Budd R, Ryan E, et al., Opsonic phagocytosis in chronic obstructive pulmonary disease is enhanced by Nrf2 agonists, American Journal of Respiratory and Critical Care Medicine, ISSN:1073-449X

Yanagisawa S, Baker JR, Vuppusetty C, et al., 2018, The dynamic shuttling of SIRT1 between cytoplasm and nuclei in bronchial epithelial cells by single and repeated cigarette smoke exposure., Plos One, Vol:13

Wrench C, Belchamber KBR, Bercusson A, et al., 2018, Reduced Clearance of Fungal Spores by Chronic Obstructive Pulmonary Disease GM-CSF- and M-CSF-derived Macrophages, American Journal of Respiratory Cell and Molecular Biology, Vol:58, ISSN:1044-1549, Pages:271-273

Belchamber KBR, Donnelly LE, 2017, Macrophage Dysfunction in Respiratory Disease., Results Probl Cell Differ, Vol:62, ISSN:0080-1844, Pages:299-313


, Administration of Resveratrol to Treat Inflammatory Respiratory Disorders, US, 09/694, 108

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