Imperial College London
Alternate

Dr Lata Govada

Faculty of Medicine, Department of Metabolism, Digestion and Reproduction

Research Associate
 
 
 
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Contact

 

+44 (0)20 7594 3037l.govada

 
 
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Location

 

Open Plan no 12Sir Alexander Fleming BuildingSouth Kensington Campus

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Summary

 

Publications

Citation

BibTex format

@article{Nanev:2021:10.1107/S2052252521000269,
author = {Nanev, C and Govada, L and Chayen, N},
doi = {10.1107/S2052252521000269},
journal = {IUCrJ},
pages = {270--280},
title = {Theoretical and experimental investigation on protein crystal nucleation in pores and crevices},
url = {http://dx.doi.org/10.1107/S2052252521000269},
volume = {8},
year = {2021}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - The nucleation ability of pores is explained using the equilibration between the cohesive energy maintaining the integrity of a crystalline cluster and the destructive energy tending to tear it up. It is shown that to get 3D crystals it is vital to have 2D crystals nucleating in the pores first. By filling the pore orifice, the 2D crystal nuclei are more stable because their peripheries are protected from the destructive action of water molecules. Furthermore, the periphery of the 2D crystal is additionally stabilized as a result of its cohesion with the pore wall. The understanding provided by this study combining theory and experiment will facilitate the design of new nucleants.
AU  - Nanev,C
AU  - Govada,L
AU  - Chayen,N
DO  - 10.1107/S2052252521000269
EP  - 280
PY  - 2021///
SN  - 2052-2525
SP  - 270
TI  - Theoretical and experimental investigation on protein crystal nucleation in pores and crevices
T2  - IUCrJ
UR  - http://dx.doi.org/10.1107/S2052252521000269
UR  - http://hdl.handle.net/10044/1/86410
VL  - 8
ER  -
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