Publications
334 results found
Reebye V, Saetrom P, Mintz PJ, et al., 2014, A Novel RNA Oligonucleotide Improves Liver Function and Inhibits Liver Carcinogenesis In Vivo, HEPATOLOGY, Vol: 59, Pages: 216-227, ISSN: 0270-9139
Frampton AE, Castellano L, Colombo T, et al., 2014, MicroRNAs Cooperatively Inhibit a Network of Tumor Suppressor Genes to Promote Pancreatic Tumor Growth and Progression, GASTROENTEROLOGY, Vol: 146, Pages: 268-+, ISSN: 0016-5085
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- Citations: 132
Gall TMH, Frampton AE, Krell J, et al., 2013, Cell-free DNA for the detection of pancreatic, liver and upper gastrointestinal cancers: has progress been made?, FUTURE ONCOLOGY, Vol: 9, Pages: 1861-1869, ISSN: 1479-6694
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- Citations: 5
Gall TMH, Frampton AE, Krell J, et al., 2013, Optimizing Unresectable Colorectal Liver Metastases for Surgery-No Limits, Any Benefits?, JOURNAL OF GASTROINTESTINAL SURGERY, Vol: 17, Pages: 2185-2187, ISSN: 1091-255X
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- Citations: 2
Qin J, Tang J, Jiao L, et al., 2013, A diterpenoid compound, excisanin A, inhibits the invasive behavior of breast cancer cells by modulating the integrin β1/FAK/PI3K/AKT/β-catenin signaling, LIFE SCIENCES, Vol: 93, Pages: 655-663, ISSN: 0024-3205
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- Citations: 29
Huang KW, Reebye V, Mintz PJ, et al., 2013, Short activating RNA (saRNA) targeting C/EBPA significantly inhibits cell proliferation of undifferentiated cancer cells., MOLECULAR CANCER THERAPEUTICS, Vol: 12, ISSN: 1535-7163
Gall TMH, Frampton AE, Krell J, et al., 2013, Is the detection of circulating tumor cells in locally advanced pancreatic cancer a useful prognostic marker?, EXPERT REVIEW OF MOLECULAR DIAGNOSTICS, Vol: 13, Pages: 793-796, ISSN: 1473-7159
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- Citations: 10
Huang J, Zhang Y, Peng Z, et al., 2013, A modified TNM-7 staging system to better predict the survival in patients with hepatocellular carcinoma after hepatectomy, JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY, Vol: 139, Pages: 1709-1719, ISSN: 0171-5216
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- Citations: 20
Shrestha AK, Pai M, Jiao LR, et al., 2013, Resection margin status and long-term outcome using radiofrequency energy as a resection tool for colorectal liver metastases, International Surgical Congress of the Association-of-Surgeons-of-Great-Britain-and-Ireland (ASGBI), Publisher: WILEY-BLACKWELL, Pages: 128-129, ISSN: 0007-1323
Pai M, Frampton AE, Virk JS, et al., 2013, Preoperative Superselective Mesenteric Angiography and Methylene Blue Injection for Localization of Obscure Gastrointestinal Bleeding, JAMA SURGERY, Vol: 148, Pages: 665-668, ISSN: 2168-6254
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- Citations: 14
Kallis Y, Phillips N, Steel A, et al., 2013, ANALYSIS OF LONG-TERM OUTCOMES AFTER ENDOSCOPIC RADIOFREQUENCY ABLATION FOR BILE DUCT STRICTURES IN PANCREATIC MALIGNANCY SUGGESTS POTENTIAL SURVIVAL BENEFIT, Annual General Meeting of the British-Society-of-Gastroenterology, Publisher: BMJ PUBLISHING GROUP, Pages: A32-A32, ISSN: 0017-5749
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- Citations: 1
Zabron A, Frampton A, Krell J, et al., 2013, SPECIFIC MICRORNA MARKERS ARE IDENTIFIED IN BILE IN PANCREATIC DUCTAL ADENOCARCINOMA, Annual General Meeting of the British-Society-of-Gastroenterology, Publisher: BMJ PUBLISHING GROUP, Pages: A17-A17, ISSN: 0017-5749
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- Citations: 1
Zabron A, Frampton A, Krell J, et al., 2013, BILIARY MICRORNA MARKERS IN BILE AID THE DIAGNOSIS OF CHOLANGIOCARCINOMA AT ERCP, Annual General Meeting of the British-Society-of-Gastroenterology, Publisher: BMJ PUBLISHING GROUP, Pages: A80-A80, ISSN: 0017-5749
Zacharoulis D, Sioka E, Tzovaras G, et al., 2013, Laparoscopic Left Lateral Sectionectomy with the Use of Habib 4X: Technical Aspects, JOURNAL OF LAPAROENDOSCOPIC & ADVANCED SURGICAL TECHNIQUES, Vol: 23, Pages: 549-552, ISSN: 1092-6429
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- Citations: 12
Atalar K, Warren OJ, Jacyna M, et al., 2013, Laparoscopic Resection for Primary Lymph Node Gastrinoma, PANCREAS, Vol: 42, Pages: 723-725, ISSN: 0885-3177
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- Citations: 7
Frampton AE, Gall TMH, Giovannetti E, et al., 2013, Distinct miRNA profiles are associated with malignant transformation of pancreatic cystic tumors revealing potential biomarkers for clinical use, EXPERT REVIEW OF MOLECULAR DIAGNOSTICS, Vol: 13, Pages: 325-329, ISSN: 1473-7159
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- Citations: 9
Pellegrino L, Stebbing J, Braga VM, et al., 2013, miR-23b regulates cytoskeletal remodeling, motility and metastasis by directly targeting multiple transcripts, Nucleic Acids Research, Vol: 41, Pages: 5400-5412, ISSN: 1362-4962
Uncontrolled cell proliferation and cytoskeletal remodeling are responsible for tumor development and ultimately metastasis. A number of studies have implicated microRNAs in the regulation of cancer cell invasion and migration. Here, we show that miR-23b regulates focal adhesion, cell spreading, cell-cell junctions and the formation of lamellipodia in breast cancer (BC), implicating a central role for it in cytoskeletal dynamics. Inhibition of miR-23b, using a specific sponge construct, leads to an increase of cell migration and metastatic spread in vivo, indicating it as a metastatic suppressor microRNA. Clinically, low miR-23b expression correlates with the development of metastases in BC patients. Mechanistically, miR-23b is able to directly inhibit a number of genes implicated in cytoskeletal remodeling in BC cells. Through intracellular signal transduction, growth factors activate the transcription factor AP-1, and we show that this in turn reduces miR-23b levels by direct binding to its promoter, releasing the pro-invasive genes from translational inhibition. In aggregate, miR-23b expression invokes a sophisticated interaction network that co-ordinates a wide range of cellular responses required to alter the cytoskeleton during cancer cell motility.
Acharya MN, Panagiotopoulos N, Cohen P, et al., 2013, Poorly-differentiated signet-ring cell carcinoma of the ampulla of Vater: report of a rare malignancy., JOP, Vol: 14, Pages: 190-194
CONTEXT: Signet-ring cell carcinoma (SRCC) of the ampulla of Vater is a very rare clinical entity, which is infrequently reported in medical literature. CASE REPORT: A 78-year-old woman was admitted with jaundice, pruritus and postprandial vomiting. Abdominal ultrasound and computed tomography scanning demonstrated gross dilatation of the common bile and pancreatic ducts with gallbladder calculi. Endoscopic retrograde cholangiopancreatography suggested a duodenal tumour at the ampulla. The patient underwent Whipple's procedure with cholecystectomy. Immunohistopathological examination confirmed poorly-differentiated SRCC of the ampulla of Vater. The tumour had infiltrated the duodenal muscularis propria and pancreatic parenchyma, but local lymph nodes were clear (T3N0M0). The patient was disease-free at 6-month follow-up. CONCLUSIONS: We here report a case of poorly-differentiated SRCC of the Ampulla of Vater. The majority of patients with such tumours undergo pancreaticoduodenectomy, which affords good outcomes in early disease. However, owing to the rarity of cases, the exact prognosis of ampullary SRCC remains as yet undetermined.
Christophides T, Frampton AE, Cohen P, et al., 2013, Reactive lymphoid hyperplasia of the pancreas: a clinical conundrum., JOP, Vol: 14, Pages: 207-211
CONTEXT: Localized reactive lymphoid hyperplasia is a rare condition characterized by the presence of lymphoid follicles. CASE REPORT: We describe a case of a 60-year-old woman who presented with right upper quadrant pain and was found to have a reactive nodular hyperplasia of the pancreas involving the uncinate process, body and tail of the gland. Due to the multifocal distribution of these hypoechoic vascular lesions, a total pancreatectomy was performed since malignancy could not be safely excluded. CONCLUSION: There have been a handful of cases reporting reactive lymphoid hyperplasia affecting the pancreas; however, it is uncommon to perform such a radical pancreatic resection for this benign condition.
Caponi S, Funel N, Frampton AE, et al., 2013, The good, the bad and the ugly: a tale of miR-101, miR-21 and miR-155 in pancreatic intraductal papillary mucinous neoplasms, ANNALS OF ONCOLOGY, Vol: 24, Pages: 734-741, ISSN: 0923-7534
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- Citations: 71
Gall TMH, Frampton AE, Krell J, et al., 2013, Blood-based miRNAs as noninvasive diagnostic and surrogative biomarkers in colorectal cancer, EXPERT REVIEW OF MOLECULAR DIAGNOSTICS, Vol: 13, Pages: 141-145, ISSN: 1473-7159
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- Citations: 12
Xu C, Zeng Q, Xu W, et al., 2013, miRNA-100 Inhibits Human Bladder Urothelial Carcinogenesis by Directly Targeting mTOR, MOLECULAR CANCER THERAPEUTICS, Vol: 12, Pages: 207-219, ISSN: 1535-7163
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- Citations: 78
Gall TMH, Frampton AE, Krell J, et al., 2013, Circulating molecular markers in pancreatic cancer: ready for clinical use?, FUTURE ONCOLOGY, Vol: 9, Pages: 141-144, ISSN: 1479-6694
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- Citations: 3
Walker NF, Warren OJ, Gawn L, et al., 2013, The role of genetic testing in management of hereditary chronic pancreatitis, JRSM Open, Vol: 4, Pages: 1-3, ISSN: 2054-2704
Frampton AE, Gall TMH, Krell J, et al., 2013, Is there a 'margin' for error in pancreatic cancer surgery?, FUTURE ONCOLOGY, Vol: 9, Pages: 31-34, ISSN: 1479-6694
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- Citations: 7
Frampton AE, Gall TMH, Castellano L, et al., 2013, Towards a clinical use of miRNAs in pancreatic cancer biopsies, EXPERT REVIEW OF MOLECULAR DIAGNOSTICS, Vol: 13, Pages: 31-34, ISSN: 1473-7159
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- Citations: 16
Drymousis P, Pai M, Spalding D, et al., 2013, Is octreotide beneficial in patients undergoing pancreaticoduodenectomy? Best evidence topic (BET), INTERNATIONAL JOURNAL OF SURGERY, Vol: 11, Pages: 779-782, ISSN: 1743-9191
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- Citations: 8
Frampton AL, Krell J, Giovannetti E, et al., 2012, Role of miRNAs in the response to anticancer therapy, PHARMACOGENOMICS, Vol: 13, Pages: 1663-1666, ISSN: 1462-2416
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- Citations: 2
Frampton AE, Krell J, Zhang Y, et al., 2012, The role of miR-10b in metastatic pancreatic ductal adenocarcinoma, SURGERY, Vol: 152, Pages: 936-938, ISSN: 0039-6060
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- Citations: 6
Zhang Y, Frampton AE, Martin JL, et al., 2012, 18F-fluorodeoxyglucose positron emission tomography in management of pancreatic cystic tumors, NUCLEAR MEDICINE AND BIOLOGY, Vol: 39, Pages: 982-985, ISSN: 0969-8051
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- Citations: 8
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