Publications
334 results found
Jiao LR, Ayav A, Navarra G, et al., 2008, Laparoscopic liver resection assisted by the laparoscopic Habib Sealer, SURGERY, Vol: 144, Pages: 770-774, ISSN: 0039-6060
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- Citations: 15
P Limongelli, SE Khorsandi, M Pai, et al., 2008, Management of delayed postoperative haemorrhage after pancreaticoduodenectomy: A meta-analysis, Arch Surg
Jiao L, Apostolopoulos C, Stebbing J, 2008, Circulating tumour cells as tumour markers, Advances in Breast Cancer, Vol: 5, Pages: 59-61, ISSN: 1742-0946
In the future, one can envision a primary assessment of the risk of recurrence with molecular prognostic profiles, followed by assessment of markers that would guide the choice of appropriate agents in those patients deemed to be at sufficient risk. Although this adds significant costs to therapy, it is less expensive than dealing with recurrence or treating patients unnecessarily. A comprehensive analysis of the properties of CTCs is likely to provide new insights into the biology of breast cancer from a peripheral blood test, and contribute to defining novel treatments and better prediction of clinical benefit. At Imperial College, CTCs will now be measured in clinical trials as an endpoint. Importantly, they allow the study of surface receptors and their changes over time without requiring the need for repeat biopsy of the primary (or metastatic) cancer, provided that CTCs represent cells en route to metastasis, an as yet unconfirmed assertion.
Damrah O, Bansi D, Habib N, et al., 2008, Treatment of liver metastasis from Gastrointestinal Stromal Tumours: multimodal approach, JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY, Vol: 23, Pages: A44-A45, ISSN: 0815-9319
Damrah OM, Bansi D, Tait P, et al., 2008, Repeat trans-arterial chemoembolisation for unresectable hepatocellular carcinoma: efficacy and long-term survival, JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY, Vol: 23, Pages: A43-A44, ISSN: 0815-9319
Healey AJ, Limogelli P, Jiao LR, 2008, Re: preoperative portal vein embolization for major liver resection., Ann Surg, Vol: 248, Pages: 500-500, ISSN: 1528-1140
Pai M, Jiao LR, Khorsandi S, et al., 2008, Liver resection with bipolar radiofrequency device: Habib™ 4X, HPB, Vol: 10, Pages: 256-260, ISSN: 1365-182X
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- Citations: 48
Pai M, Navarra G, Ayav A, et al., 2008, Laparoscopic Habib™ 4X: a bipolar radiofrequency device for bloodless laparoscopic liver resection, HPB, Vol: 10, Pages: 261-264, ISSN: 1365-182X
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- Citations: 19
Pai M, Zacharoulis D, Milicevic MN, et al., 2008, Autologous infusion of expanded mobilized adult bone marrow-derived CD34+ cells into patients with alcoholic liver cirrhosis, AMERICAN JOURNAL OF GASTROENTEROLOGY, Vol: 103, Pages: 1952-1958, ISSN: 0002-9270
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- Citations: 164
P Limongelli MD, M Pai MD, O Damrah MD, et al., 2008, CYSTIC TUMOURS OF BILIARY TRACT, World J Surg
Khorsandi SE, Bachellier P, Weber JC, et al., 2008, Minimally invasive and selective hydrodynamic gene therapy of liver segments in the pig and human., Cancer Gene Therapy, Vol: 15, Pages: 225-230
Ayav A, Jiao L, Dickinson R, et al., 2008, Liver Resection With a New Multiprobe Bipolar Radiofrequency Device, Archives 0f Surgery 2008;143(4):396-401., Vol: 143, Pages: 396-401, ISSN: 0004-0010
Hypothesis Liver resection can be associated with marked blood loss. A novel multiprobe bipolar radiofrequency device (Habib 4X; RITA Medical Systems Inc, Fremont, California) has been developed to assist in liver resection and to reduce intraoperative blood loss. Design Prospective study. Setting Tertiary referral unit. Patients Sixty-two patients requiring liver resection between November 1, 2004, and February 28, 2006, primarily for metastatic cancer. Intervention Liver resection with the radiofrequency device. Main Outcome Measures Intraoperative blood loss, liver parenchyma transection time, and complications. Results There were 51 minor and 11 major hepatectomies. Mean (SD) transection time was 39 (27) seconds per square centimeter. Mean (SD) blood loss was 4.8 (5.6) mL per square centimeter. No patient required hepatic inflow occlusion. One patient required blood transfusion. There were no deaths, and the morbidity rate was 18%. Mean (SD) hospital stay was 8 (3) days. Conclusions This new bipolar radiofrequency device allows minor and major hepatectomies to be performed with minimal blood loss, low blood transfusion requirement, and reduced mortality and morbidity rates.
Khorsandi SE, Limongelli P, Jackson JE, et al., 2008, Management of delayed arterial hemorrhage after pancreaticoduodenectomy. A case series., JOP, Vol: 9, Pages: 172-178
UNLABELLED: CONTEXT Delayed arterial hemorrhage is a rare complication after pancreaticoduodenectomy (frequency 2-4%) but carries a high mortality, with up to a third of patients dying as a consequence. Its ideal management remains unclear. CASE SERIES: Between 1993 and 2007, 317 head of pancreas resections were performed at our institution; there were 5 cases of delayed arterial hemorrhage (frequency 1.6%). CONCLUSION: This paper presents our experience in the management of delayed arterial haemorrhage post pancreaticoduodenecomy and discusses the role of angiograms, endoscopy and laparotomy in its management.
Levicar N, Pai M, Habib NA, et al., 2008, Long-term clinical results of autologous infusion of mobilized adult bone marrow derived CD34(+) cells in patients with chronic, CELL PROLIFERATION, Vol: 41, Pages: 115-125, ISSN: 0960-7722
Evidence is growing in support of the role of stem cells as an attractive alternative in treatment of liver diseases. Recently, we have demonstrated the feasibility and safety of infusing CD34(+) adult stem cells; this was performed on five patients with chronic liver disease. Here, we present the results of long-term follow-up of these patients. Between 1 x 10(6) and 2 x 10(8) CD34(+) cells were isolated and injected into the portal vein or hepatic artery. The patients were monitored for side effects, toxicity and changes in clinical, haematological and biochemical parameters; they were followed up for 12-18 months. All patients tolerated the treatment protocol well without any complications or side effects related to the procedure, also there were no side effects noted on long-term follow-up. Four patients showed an initial improvement in serum bilirubin level, which was maintained for up to 6 months. There was marginal increase in serum bilirubin in three of the patients at 12 months, while the fourth patient's serum bilirubin increased only at 18 months post-infusion. Computed tomography scan and serum alpha-foetoprotein monitoring showed absence of focal lesions. The study indicated that the stem cell product used was safe in the short and over long term, by absence of tumour formation. The investigation also illustrated that the beneficial effect seemed to last for around 12 months. This trial shows that stem cell therapy may have potential as a possible future therapeutic protocol in liver regeneration.
Healey AJ, Dimarakis I, Pai M, et al., 2008, Delayed presentation of isolated complete pancreatic transection as a result of sport-related blunt trauma to the abdomen., Case Rep Gastroenterol, Vol: 2, Pages: 22-26, ISSN: 1662-0631
INTRODUCTION: Blunt abdominal trauma is a rare but well-recognized cause of pancreatic transection. A delayed presentation of pancreatic fracture following sport-related blunt trauma with the coexisting diagnostic pitfalls is presented. CASE REPORT: A 17-year-old rugby player was referred to our specialist unit after having been diagnosed with traumatic pancreatic transection, having presented 24 h after a sporting injury. Despite haemodynamic stability, at laparotomy he was found to have a diffuse mesenteric hematoma involving the large and small bowel mesentery, extending down to the sigmoid colon from the splenic flexure, and a large retroperitoneal hematoma arising from the pancreas. The pancreas was completely severed with the superior border of the distal segment remaining attached to the splenic vein that was intact. A distal pancreatectomy with spleen preservation and evacuation of the retroperitoneal hematoma was performed. DISCUSSION/CONCLUSION: Blunt pancreatic trauma is a serious condition. Diagnosis and treatment may often be delayed, which in turn may drastically increase morbidity and mortality. Diagnostic difficulties apply to both paraclinical and radiological diagnostic methods. A high index of suspicion should be maintained in such cases, with a multi-modality diagnostic approach and prompt surgical intervention as required.
Abulkhir A, Limongelli P, Healey J, et al., 2008, Preoperative portal vein embolization for major liver reseaction. A meta-analysis, Annals of Surgery, Vol: 247(1), Pages: 49-57
Healey AJ, Reed A, Jiao LR, 2008, Pancreatic mass with an unusual pathology: a case report., HPB Surg, Vol: 2008
Intra-abdominal abscesses formation in patients with no preceding symptoms is rare. Infection of the pancreas occurs in 5-9% of patients with acute pancreatitis, more commonly as a complication of necrotising or severe pancreatitis. We have reported a case of a 64-year-old almost entirely asymptomatic man who underwent a Whipple's procedure following extensive investigation of a pancreatic mass. The pathology and histology showed no evidence of malignancy, and instead a true pancreatic abscess, centred around an impacted cholesterol calculus in the distal CBD. Of suspicious pancreatic masses that are resected, chronic choledocholithiasis is the aetiology in less than 5% of nonmalignant or "false positives." This report describes such a case.
El-Gendi AM, Khorsandi SE, Pai M, et al., 2008, Repeat hepatic resection using a radiofrequency-assisted technique, DIGESTIVE SURGERY, Vol: 25, Pages: 293-299, ISSN: 0253-4886
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- Citations: 6
Tamir A, Basaglia E, Kagahzian A, et al., 2007, Erratum: Induction of tumor-specific T-cell responses by vaccination with tumor lysate-loaded dendritic cells in colorectal cancer patients with carcinoembryonic-antigen positive tumors (Cancer Immunology, Immunotherapy DOI 10.1007/s00262-007-0299-y), Cancer Immunology, Immunotherapy, Vol: 56, ISSN: 0340-7004
Tamir A, Basaglia E, Kagahzian A, et al., 2007, Induction of tumor-specific T-cell responses by vaccination with tumor lysate-loaded dendritic cells in colorectal cancer patients with carcinoembryonic-antigen positive tumors, CANCER IMMUNOLOGY IMMUNOTHERAPY, Vol: 56, Pages: 2003-2016, ISSN: 0340-7004
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- Citations: 42
Abulkhir A, Limongelli P, Healey A, et al., 2007, PREOPERATIVE PORTAL VEIN EMBOLISATION FOR MAJOR LIVER RESECTION – A META-ANALYSIS, Ann Surg
Wheeler PG, Atrey A, Healey A, et al., 2007, A cause of cholestatic jaundice, GUT, Vol: 56, Pages: 1346-+, ISSN: 0017-5749
Jiao LR, Szyszko T, Al-Nahhas A, et al., 2007, Clinical and imaging experience with yttrium-90 microspheres in the management of unresectable liver tumours, EJSO, Vol: 33, Pages: 597-602, ISSN: 0748-7983
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- Citations: 35
Limongelli P, Pai M, Bansi D, et al., 2007, Correlation between preoperative biliary drainage, bile duct contamination and postoperative outcomes for pancreatic surgery, Surgery
Ayav A, Navarra G, Basaglia E, et al., 2007, Results of major hepatectomy without vascular clamping using radiofrequency-assisted technique compared with total vascular exclusion, HEPATO-GASTROENTEROLOGY, Vol: 54, Pages: 806-809, ISSN: 0172-6390
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- Citations: 2
Bachellier P, Ayav A, Pai M, et al., 2007, Laparoscopic liver resection assisted with radiofrequency, AMERICAN JOURNAL OF SURGERY, Vol: 193, Pages: 427-430, ISSN: 0002-9610
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- Citations: 24
Damrah OM, Lauretta A, Thillinianagram A, et al., 2007, Management of benign biliary strictures: Endoscopy versus surgery, institutional experience, Annual Meeting of the British-Society-of-Gastroenterology, Publisher: B M J PUBLISHING GROUP, Pages: A88-A88, ISSN: 0017-5749
East JE, Troup S, Mawdsley J, et al., 2007, Vascular endothelial growth factor and calprotectin in blood and bile for diagnosis of pancreatobiliary carcinoma: A pilot study, Annual Meeting of the British-Society-of-Gastroenterology, Publisher: B M J PUBLISHING GROUP, Pages: A75-A75, ISSN: 0017-5749
Simillis C, Constantinides VA, Tekkis PP, et al., 2007, Laparoscopic versus open hepatic resections for benign and malignant neoplasms - a meta-analysis, SURGERY, Vol: 141, Pages: 203-211, ISSN: 0039-6060
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- Citations: 274
Ayav A, Bachellier P, Habib NA, et al., 2007, Impact of radiofrequency assisted hepatectomy for reduction of transfusion requirements, AMERICAN JOURNAL OF SURGERY, Vol: 193, Pages: 143-148, ISSN: 0002-9610
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- Citations: 37
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