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@article{Jawad:2017:10.1038/s41598-017-14688-z,
author = {Jawad, ZAR and Theodorou, I and Jiao, LR and Xie, F},
doi = {10.1038/s41598-017-14688-z},
journal = {Scientific Reports},
title = {Highly Sensitive Plasmonic Detection of the Pancreatic Cancer Biomarker CA 19-9},
url = {http://dx.doi.org/10.1038/s41598-017-14688-z},
volume = {7},
year = {2017}
}

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TY  - JOUR
AB  - Plasmonic gold (Au) nanotriangular arrays, functionalized with a near infrared (NIR) fuorophoreconjugatedimmunoassay to Carbohydrate Antigen 19-9 (CA 19-9), a pancreatic cancer biomarker,produce optically tunable substrates with two orders of magnitude fuorescence enhancement.Through nanoscale morphological control, the sensitivities of the plasmonic nanotriangular arraysare controllable, paving the way of such optical platforms for multiplexing. Here, we report a limit ofdetection (LOD) of 7.7×10−7 U.mL−1 for CA 19–9 by using such tunable Au nanotriangular arrays, agreat improvement compared to commercially available CA 19–9 immunoassays. The linear dynamicrange was from 1×10−6 U.mL−1 to 1 U.mL−1, i.e. up to six orders of magnitude. Moreover, highspecifcity was demonstrated, together with successful validation in serum samples. Their superiortunable sensitivity, along with eforts to combine CA 19–9 with other biomarkers for improved accuracy,open up the possibility for multiplexed NIR-fuorescence enhancement microarrays, for early cancerdiagnosis and therapeutic monitoring.
AU  - Jawad,ZAR
AU  - Theodorou,I
AU  - Jiao,LR
AU  - Xie,F
DO  - 10.1038/s41598-017-14688-z
PY  - 2017///
SN  - 2045-2322
TI  - Highly Sensitive Plasmonic Detection of the Pancreatic Cancer Biomarker CA 19-9
T2  - Scientific Reports
UR  - http://dx.doi.org/10.1038/s41598-017-14688-z
UR  - http://hdl.handle.net/10044/1/51822
VL  - 7
ER  -

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Professor Long R Jiao MD FRCS

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