Publications

BibTex format

@article{Kramer:2018:10.1007/s00259-017-3923-x,
author = {Kramer, GM and Liu, Y and de, Langen AJ and Jansma, EP and Trigonis, I and Asselin, M-C and Jackson, A and Kenny, L and Aboagye, EO and Hoekstra, OS and Boellaard, R and QuIC-ConCePT, consortium},
doi = {10.1007/s00259-017-3923-x},
journal = {European Journal of Nuclear Medicine and Molecular Imaging},
pages = {951--961},
title = {Repeatability of quantitative18F-FLT uptake measurements in solid tumors: an individual patient data multi-center meta-analysis},
url = {http://dx.doi.org/10.1007/s00259-017-3923-x},
volume = {45},
year = {2018}
}

Download

RIS format (EndNote, RefMan)

TY  - JOUR
AB  - INTRODUCTION: 3'-deoxy-3'-[18F]fluorothymidine (18F-FLT) positron emission tomography (PET) provides a non-invasive method to assess cellular proliferation and response to antitumor therapy. Quantitative18F-FLT uptake metrics are being used for evaluation of proliferative response in investigational setting, however multi-center repeatability needs to be established. The aim of this study was to determine the repeatability of18F-FLT tumor uptake metrics by re-analyzing individual patient data from previously published reports using the same tumor segmentation method and repeatability metrics across cohorts. METHODS: A systematic search in PubMed, EMBASE.com and the Cochrane Library from inception-October 2016 yielded five18F-FLT repeatability cohorts in solid tumors.18F-FLT avid lesions were delineated using a 50% isocontour adapted for local background on test and retest scans. SUVmax, SUVmean, SUVpeak, proliferative volume and total lesion uptake (TLU) were calculated. Repeatability was assessed using the repeatability coefficient (RC = 1.96 × SD of test-retest differences), linear regression analysis, and the intra-class correlation coefficient (ICC). The impact of different lesion selection criteria was also evaluated. RESULTS: Images from four cohorts containing 30 patients with 52 lesions were obtained and analyzed (ten in breast cancer, nine in head and neck squamous cell carcinoma, and 33 in non-small cell lung cancer patients). A good correlation was found between test-retest data for all18F-FLT uptake metrics (R2 ≥ 0.93; ICC ≥ 0.96). Best repeatability was found for SUVpeak(RC: 23.1%), without significant differences in RC between different SUV metrics. Repeatability of proliferative volume (RC: 36.0%) and TLU (RC: 36.4%) was worse than SUV. Lesion selection methods based on SUVmax ≥ 4.0 improved the repeatability of volumetric metrics (RC: 26-28%), but did not affect the repe
AU  - Kramer,GM
AU  - Liu,Y
AU  - de,Langen AJ
AU  - Jansma,EP
AU  - Trigonis,I
AU  - Asselin,M-C
AU  - Jackson,A
AU  - Kenny,L
AU  - Aboagye,EO
AU  - Hoekstra,OS
AU  - Boellaard,R
AU  - QuIC-ConCePT,consortium
DO  - 10.1007/s00259-017-3923-x
EP  - 961
PY  - 2018///
SN  - 1619-7070
SP  - 951
TI  - Repeatability of quantitative18F-FLT uptake measurements in solid tumors: an individual patient data multi-center meta-analysis
T2  - European Journal of Nuclear Medicine and Molecular Imaging
UR  - http://dx.doi.org/10.1007/s00259-017-3923-x
UR  - https://www.ncbi.nlm.nih.gov/pubmed/29362858
UR  - http://hdl.handle.net/10044/1/57964
VL  - 45
ER  -

Download

DrLauraKenny

Contact

Location

Summary

Citation

BibTex format

RIS format (EndNote, RefMan)