Imperial College London

DrLucaMagnani

Faculty of MedicineDepartment of Surgery & Cancer

Senior Research Fellow
 
 
 
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Contact

 

+44 (0)20 7594 2808l.magnani CV

 
 
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Location

 

140ICTEM buildingHammersmith Campus

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Summary

 

Publications

Publication Type
Year
to

73 results found

Bianco S, Brunelle M, Jangal M, Magnani L, Gevry Net al., 2014, LRH-1 Governs Vital Transcriptional Programs in Endocrine-Sensitive and -Resistant Breast Cancer Cells, CANCER RESEARCH, Vol: 74, Pages: 2015-2025, ISSN: 0008-5472

JOURNAL ARTICLE

Gadaleta RM, Magnani L, 2014, Nuclear receptors and chromatin: an inducible couple, JOURNAL OF MOLECULAR ENDOCRINOLOGY, Vol: 52, Pages: R137-R149, ISSN: 0952-5041

JOURNAL ARTICLE

Magnani L, Lupien M, 2014, Chromatin and epigenetic determinants of estrogen receptor alpha (ESR1) signaling, MOLECULAR AND CELLULAR ENDOCRINOLOGY, Vol: 382, Pages: 633-641, ISSN: 0303-7207

JOURNAL ARTICLE

Lombardo Y, Faronato M, Filipovic A, Vircillo V, Magnani L, Coombes RCet al., 2014, Nicastrin and Notch4 drive endocrine therapy resistance and epithelial to mesenchymal transition in MCF7 breast cancer cells, BREAST CANCER RESEARCH, Vol: 16, ISSN: 1465-542X

JOURNAL ARTICLE

Magnani L, 2014, Epigenetic engineering and the art of epigenetic manipulation, GENOME BIOLOGY, Vol: 15, ISSN: 1465-6906

JOURNAL ARTICLE

Magnani L, Stoeck A, Zhang X, Lanczky A, Mirabella AC, Wang T-L, Gyorffy B, Lupien Met al., 2013, Genome-wide reprogramming of the chromatin landscape underlies endocrine therapy resistance in breast cancer, PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, Vol: 110, Pages: E1490-E1499, ISSN: 0027-8424

JOURNAL ARTICLE

Magnani L, Carroll J, Zwart W, Palmieri Cet al., 2012, ChIPing away at breast cancer, LANCET ONCOLOGY, Vol: 13, Pages: 1185-1187, ISSN: 1470-2045

JOURNAL ARTICLE

Magnani L, Brunelle M, Gevry N, Lupien Met al., 2012, Chromatin landscape and endocrine response in breast cancer, EPIGENOMICS, Vol: 4, Pages: 675-683, ISSN: 1750-1911

JOURNAL ARTICLE

Thiaville MM, Stoeck A, Chen L, Wu R-C, Magnani L, Oidtman J, Shih I-M, Lupien M, Wang T-Let al., 2012, Identification of PBX1 Target Genes in Cancer Cells by Global Mapping of PBX1 Binding Sites, PLOS ONE, Vol: 7, ISSN: 1932-6203

JOURNAL ARTICLE

Wang X, Park K-E, Koser S, Liu S, Magnani L, Cabot RAet al., 2012, KPNA7, an oocyte- and embryo-specific karyopherin alpha subtype, is required for porcine embryo development, REPRODUCTION FERTILITY AND DEVELOPMENT, Vol: 24, Pages: 382-391, ISSN: 1031-3613

JOURNAL ARTICLE

Magnani L, Ballantyne EB, Zhang X, Lupien Met al., 2011, PBX1 Genomic Pioneer Function Drives ER alpha Signaling Underlying Progression in Breast Cancer, PLOS GENETICS, Vol: 7, ISSN: 1553-7404

JOURNAL ARTICLE

Magnani L, Eeckhoute J, Lupien M, 2011, Pioneer factors: directing transcriptional regulators within the chromatin environment, TRENDS IN GENETICS, Vol: 27, Pages: 465-474, ISSN: 0168-9525

JOURNAL ARTICLE

Wang K, Sengupta S, Magnani L, Wilson CA, Henry RW, Knott JGet al., 2010, Brg1 Is Required for Cdx2-Mediated Repression of Oct4 Expression in Mouse Blastocysts, PLOS ONE, Vol: 5, ISSN: 1932-6203

JOURNAL ARTICLE

Park K-E, Johnson CM, Magnani L, Wang X, Biancardi MN, Cabot RAet al., 2010, Global H3K9 Dimethylation Status Is Not Affected by Transcription, Translation, or DNA Replication in Porcine Zygotes, MOLECULAR REPRODUCTION AND DEVELOPMENT, Vol: 77, Pages: 420-429, ISSN: 1040-452X

JOURNAL ARTICLE

Dinelli BM, Arnone E, Brizzi G, Carlotti M, Castelli E, Magnani L, Papandrea E, Prevedelli M, Ridolfi Met al., 2010, The MIPAS2D database of MIPAS/ENVISAT measurements retrieved with a multi-target 2-dimensional tomographic approach, ATMOSPHERIC MEASUREMENT TECHNIQUES, Vol: 3, Pages: 355-374, ISSN: 1867-1381

JOURNAL ARTICLE

Park K-E, Magnani L, Cabot RA, 2009, Differential Remodeling of Mono- and Trimethylated H3K27 During Porcine Embryo Development, MOLECULAR REPRODUCTION AND DEVELOPMENT, Vol: 76, Pages: 1033-1042, ISSN: 1040-452X

JOURNAL ARTICLE

Xing X, Magnani L, Lee K, Wang C, Cabot RA, Machaty Zet al., 2009, Gene Expression and Development of Early Pig Embryos Produced by Serial Nuclear Transfer, MOLECULAR REPRODUCTION AND DEVELOPMENT, Vol: 76, Pages: 555-563, ISSN: 1040-452X

JOURNAL ARTICLE

Carlotti M, Magnani L, 2009, Two-dimensional sensitivity analysis of MIPAS observations., Opt Express, Vol: 17, Pages: 5340-5357

In this paper we propose a new approach to operate two-dimensional sensitivity studies on the observations of MIPAS, an experiment on board the ENVISAT satellite. The proposed analysis system is intended to evaluate the amount and the spatial distribution of the information that is carried by MIPAS observations with respect to the target atmospheric parameters. The new approach enables the definition and assessment of the target-dependent atmospheric sampling of the measurements. The amount of information is evaluated by merging MIPAS measurements, relative to different limb-scans, in a two-dimensional analysis that models the sensitivity of the spectral signals combined with the geometrical redundancy introduced by different observation geometries. The spatial distribution of the information that is obtained with our analysis highlights the advantage of using a two-dimensional retrieval system. Furthermore, within the two-dimensional context, this analysis provides crucial indications for the definition of the optimal retrieval grid and, therefore, for the best exploitation of existing measurements. The proposed analysis is also suited for the design of optimized observation strategies. The sensitivity analysis, applied in this paper to MIPAS observations, can be extended to other orbiting limb sounders that, like MIPAS, continuously measure the atmospheric emission along the orbit track.

JOURNAL ARTICLE

Wang X, Magnani L, Cabot R, 2009, KARYOPHERIN alpha EXPRESSION IN PORCINE OOCYTES AND EMBRYOS PRODUCED BY IN VITRO FERTILIZATION, REPRODUCTION FERTILITY AND DEVELOPMENT, Vol: 21, Pages: 197-198, ISSN: 1031-3613

JOURNAL ARTICLE

Biancardi MN, Magnani L, Johnson CM, Cabot RAet al., 2009, TRANSCRIPT ABUNDANCE OF METHYLTRANSFERASES SPECIFIC FOR H3K9 DIFFER AT DISCRETE STAGES OF PORCINE OOCYTE AND CLEAVAGE STAGE EMBRYO DEVELOPMENT, REPRODUCTION FERTILITY AND DEVELOPMENT, Vol: 21, Pages: 188-188, ISSN: 1031-3613

JOURNAL ARTICLE

Magnani L, Cabot RA, 2009, Manipulation of SMARCA2 and SMARCA4 transcript levels in porcine embryos differentially alters development and expression of SMARCA1, SOX2 NANOG, and EIF1, REPRODUCTION, Vol: 137, Pages: 23-33, ISSN: 1470-1626

JOURNAL ARTICLE

Magnani L, Cabot RA, 2008, In Vitro and In Vivo Derived Porcine Embryos Possess Similar, but Not Identical, Patterns of Oct4, Nanog, and Sox2 mRNA Expression During Cleavage Development, MOLECULAR REPRODUCTION AND DEVELOPMENT, Vol: 75, Pages: 1726-1735, ISSN: 1040-452X

JOURNAL ARTICLE

Xing X, Magnani L, Lee K, Wang C, Cabot RA, Machaty Zet al., 2008, Gene expression in early porcine embryos following serial nuclear transfer, 16th International Congress on Animal Reproduction, Publisher: WILEY-BLACKWELL PUBLISHING, INC, Pages: 7-7, ISSN: 0936-6768

CONFERENCE PAPER

Magnani L, Lee K, Fodor WL, Machaty Z, Cabot RAet al., 2008, Developmental capacity of porcine nuclear transfer embryos correlate with levels of chromatin-remodeling transcripts in donor cells, MOLECULAR REPRODUCTION AND DEVELOPMENT, Vol: 75, Pages: 766-776, ISSN: 1040-452X

JOURNAL ARTICLE

Magnani L, Cabot R, 2008, Relative abundance of Oct-4, Nanog, and Sox-2 transcripts in porcine oocytes and cleavage-stage embryos produced via fertilization in vitro or parthenogenesis, REPRODUCTION FERTILITY AND DEVELOPMENT, Vol: 20, Pages: 168-169, ISSN: 1031-3613

JOURNAL ARTICLE

Magnani L, Johnson CM, Cabot RA, 2008, Expression of eukaryotic elongation initiation factor 1A differentially marks zygotic genome activation in biparental and parthenogenetic porcine embryos and correlates with in vitro developmental potential, REPRODUCTION FERTILITY AND DEVELOPMENT, Vol: 20, Pages: 818-825, ISSN: 1031-3613

JOURNAL ARTICLE

Park K, Magnani L, Cabot R, 2008, Expression patterns of H3/K27 methylation mediating genes in porcine embryos, 41st Annual Meeting of the Society-for-the-Study-of-Reproduction, Publisher: SOC STUDY REPRODUCTION, Pages: 96-97, ISSN: 0006-3363

CONFERENCE PAPER

Magnani L, Cabot R, 2008, Ectopic expression of Brahma in porcine embryos induces developmental arrest and alters expression of SNF2L, 41st Annual Meeting of the Society-for-the-Study-of-Reproduction, Publisher: SOC STUDY REPRODUCTION, Pages: 72-72, ISSN: 0006-3363

CONFERENCE PAPER

Magnani L, Cabot RA, 2007, Developmental arrest induced in cleavage stage porcine embryos following microinjection of mRNA encoding Brahma (Smarca 2), a chromatin remodeling protein, MOLECULAR REPRODUCTION AND DEVELOPMENT, Vol: 74, Pages: 1262-1267, ISSN: 1040-452X

JOURNAL ARTICLE

, 2007, MARC: A code for the retrieval of atmospheric parameters from millimeter-wave limb measurements, Journal of Quantitative Spectroscopy and Radiative Transfer, Vol: 105, Pages: 476-491, ISSN: 0022-4073

A new data analysis software is presented that has been developed for the retrieval of atmospheric minor constituents from limb-sounding observations made in the millimeter and sub-millimeter spectral regions. The code, which is called MARC (Millimetre-wave Atmospheric-Retrieval Code), has been designed to analyze the observations of the MARSCHALS (Millimetre-wave Airborne Receivers for Spectroscopic CHaracterisation in Atmospheric Limb-Sounding) instrument which operates on the M-55 stratospheric aircraft. The main objective of the analysis of MARSCHALS observations will be to assess long-wave measurement capabilities for the study of the upper troposphere and lower stratosphere regions. The key questions will be the accuracy and spatial resolution that can be achieved by long-wave measurements in presence of clouds and horizontal gradients. MARC performs a global-fit multi-target retrieval, in which optimal estimation is used and errors of the forward model parameters are taken into account for the definition of the cost function minimized in the retrieval. With these features it is easy to use the variables of the problem as either forward model constant parameters or retrieved unknowns with minimum impact on the stability of the retrieval. MARC can perform a wide spectral-band analysis of the observations without a selection of the analyzed channels, and the retrieval process provides an error budget of the retrieved unknowns that includes both the forward model errors and the measurement errors. The error budget obtained in this way is smaller than that obtained when accounting a posteriori for the systematic errors. The new combination of the retrieval features makes possible an efficient and optimal exploitation of the information content of the observations. © 2006 Elsevier Ltd. All rights reserved.

JOURNAL ARTICLE

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