Imperial College London
Alternate

ProfessorLucaMagnani

Faculty of Medicine, Department of Surgery & Cancer

Honorary Principal Research Fellow
 
 
 
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Contact

 

+44 (0)20 7594 2808l.magnani CV

 
 
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Location

 

137ICTEM buildingHammersmith Campus

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Summary

 

Publications

Citation

BibTex format

@article{Xu:2015:10.1016/j.celrep.2015.06.073,
author = {Xu, Y and Zhang, H and Van, TMN and Angelopoulos, N and Nunes, J and Reid, A and Buluwela, L and Magnani, L and Stebbing, J and Giamas, G},
doi = {10.1016/j.celrep.2015.06.073},
journal = {Cell Reports},
pages = {837--849},
title = {LMTK3 represses tumor suppressor-like genes through chromatin remodeling in breast cancer},
url = {http://dx.doi.org/10.1016/j.celrep.2015.06.073},
volume = {12},
year = {2015}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - LMTK3 is an oncogenic receptor tyrosine kinase (RTK) implicated in various types of cancer, including breast, lung, gastric, and colorectal cancer. It is localized in different cellular compartments, but its nuclear function has not been investigated so far. We mapped LMTK3 binding across the genome using ChIP-seq and found that LMTK3 binding events are correlated with repressive chromatin markers. We further identified KRAB-associated protein 1 (KAP1) as a binding partner of LMTK3. The LMTK3/KAP1 interaction is stabilized by PP1α, which suppresses KAP1 phosphorylation specifically at LMTK3-associated chromatin regions, inducing chromatin condensation and resulting in transcriptional repression of LMTK3-bound tumor suppressor-like genes. Furthermore, LMTK3 functions at distal regions in tethering the chromatin to the nuclear periphery, resulting in H3K9me3 modification and gene silencing. In summary, we propose a model where a scaffolding function of nuclear LMTK3 promotes cancer progression through chromatin remodeling.
AU  - Xu,Y
AU  - Zhang,H
AU  - Van,TMN
AU  - Angelopoulos,N
AU  - Nunes,J
AU  - Reid,A
AU  - Buluwela,L
AU  - Magnani,L
AU  - Stebbing,J
AU  - Giamas,G
DO  - 10.1016/j.celrep.2015.06.073
EP  - 849
PY  - 2015///
SN  - 2211-1247
SP  - 837
TI  - LMTK3 represses tumor suppressor-like genes through chromatin remodeling in breast cancer
T2  - Cell Reports
UR  - http://dx.doi.org/10.1016/j.celrep.2015.06.073
UR  - http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000358999800012&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=1ba7043ffcc86c417c072aa74d649202
UR  - http://hdl.handle.net/10044/1/33933
VL  - 12
ER  -
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