Imperial College London


Faculty of MedicineSchool of Public Health

Senior Lecturer & Royal Society Dorothy Hodgkin Fellow



+44 (0)20 7594 3265l.okell Website




G24Medical SchoolSt Mary's Campus





My research interests are the development of mathematical models of malaria and analysis of epidemiological data in collaboration with policy-makers to better understand malaria burden, the impact of public health interventions and to inform malaria control policy.

I currently hold a Royal Society Dorothy Hodgkin Fellowship and my research focuses on assessing use of different types of antimalarial treatments in Africa and their impact on community-wide transmission, prophylaxis, and the international spread of drug resistant Plasmodium falciparum malaria. I also have have a particular interest in the contribution of low density malaria infections to sustaining transmission.

The effect of a given malaria control intervention can often vary between different epidemiological settings, and I have applied models to specific endemic settings in Africa in collaboration with field-based staff and policy makers in order to understand where and under what conditions different strategies can be most appropriate.


Selected Publications

Journal Articles

Okell L, Reiter LM, Ebbe LS, et al., 2018, Emerging implications of policies on malaria treatment: genetic changes in the Pfmdr-1 gene affecting susceptibility to artemether-lumefantrine and artesunate-amodiaquine in Africa, Bmj Global Health, Vol:3, ISSN:2059-7908

Challenger J, Bruxvoort K, Ghani AC, et al., 2017, Assessing the impact of imperfect adherence to artemether-lumefantrine on malaria treatment outcomes using within-host modelling, Nature Communications, Vol:8, ISSN:2041-1723

Okell L, Griffin JT, Roper C, 2017, Mapping sulphadoxine-pyrimethamine-resistant Plasmodium falciparum malaria in infected humans and in parasite populations in Africa, Scientific Reports, Vol:7, ISSN:2045-2322

Brady OJ, Slater HC, Pemberton-Ross P, et al., 2017, Role of mass drug administration in elimination of Plasmodium falciparum malaria: a consensus modelling study, The Lancet Global Health, Vol:5, ISSN:2214-109X, Pages:E680-E687

Okell LC, Churcher TS, 2016, Generating the evidence base for malaria elimination: the situation in Haiti, Lancet Global Health, Vol:5, ISSN:2214-109X, Pages:e16-e17

Slater HC, Okell LC, Ghani AC, 2016, Mathematical Modelling to Guide Drug Development for Malaria Elimination, Trends in Parasitology, Vol:33, ISSN:1471-5007, Pages:175-184

Slater HC, Griffin JT, Ghani AC, et al., 2016, Assessing the potential impact of artemisinin and partner drug resistance in sub-Saharan Africa., Malaria Journal, Vol:15, ISSN:1475-2875

Wu L, van den Hoogen LL, Slater H, et al., 2015, Comparison of diagnostics for the detection of asymptomatic Plasmodium falciparum infections to inform control and elimination strategies, Nature, Vol:528, ISSN:0028-0836, Pages:S86-S93

Bousema T, Okell L, Felger I, et al., 2014, Asymptomatic malaria infections: detectability, transmissibility and public health relevance, Nature Reviews Microbiology, Vol:12, ISSN:1740-1526, Pages:833-840

Okell LC, Cairns M, Griffin JT, et al., 2014, Contrasting benefits of different artemisinin combination therapies as first-line malaria treatments using model-based cost-effectiveness analysis, Nature Communications, Vol:5, ISSN:2041-1723

Okell LC, Bousema T, Griffin JT, et al., 2012, Factors determining the occurrence of submicroscopic malaria infections and their relevance for control, Nature Communications, Vol:3, ISSN:2041-1723

Okell LC, Griffin JT, Kleinschmidt I, et al., 2011, The Potential Contribution of Mass Treatment to the Control of Plasmodium falciparum Malaria, PLOS One, Vol:6, ISSN:1932-6203

Griffin JT, Hollingsworth TD, Okell LC, et al., 2010, Reducing Plasmodium falciparum malaria transmission in Africa: a model-based evaluation of intervention strategies., Plos Med, Vol:7, ISSN:1549-1676, Pages:1-27

Bousema T, Okell L, Shekalaghe S, et al., 2010, Revisiting the circulation time of Plasmodium falciparum gametocytes: molecular detection methods to estimate the duration of gametocyte carriage and the effect of gametocytocidal drugs, Malaria Journal, Vol:9, ISSN:1475-2875

Okell LC, Ghani AC, Lyons E, et al., 2009, Submicroscopic infection in Plasmodium falciparum-endemic populations: a systematic review and meta-analysis, J Infect Dis, Vol:200, ISSN:1537-6613, Pages:1509-1517

Okell LC, Drakeley CJ, Bousema T, et al., 2008, Modelling the impact of artemisinin combination therapy and long-acting treatments on malaria transmission intensity, Plos Med, Vol:5, ISSN:1549-1676, Pages:e226-e226

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