Imperial College London

DrLucyOkell

Faculty of MedicineSchool of Public Health

Lecturer/Royal Society Dorothy Hodgkin Research Fellow
 
 
 
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Contact

 

+44 (0)20 7594 3265l.okell Website

 
 
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Location

 

G24Medical SchoolSt Mary's Campus

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Summary

 

Summary

My research interests are the development of mathematical models of malaria and analysis of epidemiological data in collaboration with policy-makers to better understand malaria burden, the impact of public health interventions and to inform malaria control policy.

I currently hold a Royal Society Dorothy Hodgkin Fellowship and my research focuses on assessing use of different types of antimalarial treatments in Africa and their impact on community-wide transmission, prophylaxis, and the international spread of drug resistant Plasmodium falciparum malaria. I also have have a particular interest in the contribution of low density malaria infections to sustaining transmission.

The effect of a given malaria control intervention can often vary between different epidemiological settings, and I have applied models to specific endemic settings in Africa in collaboration with field-based staff and policy makers in order to understand where and under what conditions different strategies can be most appropriate.

 

Selected Publications

Journal Articles

Brady OJ, Slater HC, Pemberton-Ross P, et al., 2017, Role of mass drug administration in elimination of Plasmodium falciparum malaria: a consensus modelling study, Lancet Global Health, Vol:5, ISSN:2214-109X, Pages:E680-E687

Okell LC, Churcher TS, 2017, Generating the evidence base for malaria elimination: the situation in Haiti, Lancet Global Health, Vol:5, ISSN:2214-109X, Pages:E16-E17

Slater HC, Okell LC, Ghani AC, 2017, Mathematical Modelling to Guide Drug Development for Malaria Elimination, Trends in Parasitology, Vol:33, ISSN:1471-4922, Pages:175-184

Slater HC, Griffin JT, Ghani AC, et al., 2016, Assessing the potential impact of artemisinin and partner drug resistance in sub-Saharan Africa, Malaria Journal, Vol:15, ISSN:1475-2875

Wu L, van den Hoogen LL, Slater H, et al., 2015, Comparison of diagnostics for the detection of asymptomatic Plasmodium falciparum infections to inform control and elimination strategies, Nature, Vol:528, ISSN:0028-0836, Pages:S86-S93

Okell LC, Drakeley CJ, Ghani AC, et al., 2008, Reduction of transmission from malaria patients by artemisinin combination therapies: a pooled analysis of six randomized trials, Malaria Journal, Vol:7, ISSN:1475-2875

Bousema T, Okell L, Shekalaghe S, et al., 2010, Revisiting the circulation time of Plasmodium falciparum gametocytes: molecular detection methods to estimate the duration of gametocyte carriage and the effect of gametocytocidal drugs, Malaria Journal, Vol:9, ISSN:1475-2875

Okell LC, Cairns M, Griffin JT, et al., 2014, Contrasting benefits of different artemisinin combination therapies as first-line malaria treatments using model-based cost-effectiveness analysis, Nature Communications, Vol:5, ISSN:2041-1723

Bousema T, Okell L, Felger I, et al., Asymptomatic malaria infections: detectability, transmissibility and public health relevance., Nat Rev Microbiol, Vol:12, Pages:833-840

de Souza JB, Runglall M, Corran PH, et al., 2010, Neutralization of malaria glycosylphosphatidylinositol in vitro by serum IgG from malaria-exposed individuals., Infect Immun, Vol:78, Pages:3920-3929

Okell LC, Bousema T, Griffin JT, et al., 2012, Factors determining the occurrence of submicroscopic malaria infections and their relevance for control, Nature Communications, Vol:3, ISSN:2041-1723

Griffin JT, Hollingsworth TD, Okell LC, et al., 2010, Reducing Plasmodium falciparum Malaria Transmission in Africa: A Model-Based Evaluation of Intervention Strategies, Plos Medicine, Vol:7, ISSN:1549-1676

Okell LC, Griffin JT, Kleinschmidt I, et al., 2011, The Potential Contribution of Mass Treatment to the Control of Plasmodium falciparum Malaria, PLOS One, Vol:6, ISSN:1932-6203

Okell LC, Ghani AC, Lyons E, et al., 2009, Submicroscopic Infection in Plasmodium falciparum-Endemic Populations: A Systematic Review and Meta-Analysis, Journal of Infectious Diseases, Vol:200, ISSN:0022-1899, Pages:1509-1517

Okell LC, Drakeley CJ, Bousema T, et al., 2008, Modelling the Impact of Artemisinin Combination Therapy and Long-Acting Treatments on Malaria Transmission Intensity, PLOS Medicine, Vol:5, ISSN:1549-1277, Pages:1617-1628

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