Publications

BibTex format

@article{Coomarasamy:2015:10.1056/NEJMoa1504927,
author = {Coomarasamy, A and Williams, H and Truchanowicz, E and Seed, PT and Small, R and Quenby, S and Gupta, P and Dawood, F and Koot, YEM and Atik, RB and Bloemenkamp, KWM and Brady, R and Briley, AL and Cavallaro, R and Cheong, YC and Chu, JJ and Eapen, A and Ewies, A and Hoek, A and Kaaijk, EM and Koks, CAM and Li, T-C and MacLean, M and Mol, BW and Moore, J and Ross, JA and Sharpe, L and Stewart, J and Vaithilingam, N and Farquharson, RG and Kilby, MD and Khalaf, Y and Goddijn, M and Regan, L and Rai, R},
doi = {10.1056/NEJMoa1504927},
journal = {New England Journal of Medicine},
pages = {2141--2148},
title = {A randomized trial of progesterone in women with recurrent miscarriages},
url = {http://dx.doi.org/10.1056/NEJMoa1504927},
volume = {373},
year = {2015}
}

Download

RIS format (EndNote, RefMan)

TY  - JOUR
AB  - BackgroundProgesterone is essential for the maintenance of pregnancy. However, whether progesterone supplementation in the first trimester of pregnancy would increase the rate of live births among women with a history of unexplained recurrent miscarriages is uncertain.MethodsWe conducted a multicenter, double-blind, placebo-controlled, randomized trial to investigate whether treatment with progesterone would increase the rates of live births and newborn survival among women with unexplained recurrent miscarriage. We randomly assigned women with recurrent miscarriages to receive twice-daily vaginal suppositories containing either 400 mg of micronized progesterone or matched placebo from a time soon after a positive urinary pregnancy test (and no later than 6 weeks of gestation) through 12 weeks of gestation. The primary outcome was live birth after 24 weeks of gestation.ResultsA total of 1568 women were assessed for eligibility, and 836 of these women who conceived naturally within 1 year and remained willing to participate in the trial were randomly assigned to receive either progesterone (404 women) or placebo (432 women). The follow-up rate for the primary outcome was 98.8% (826 of 836 women). In an intention-to-treat analysis, the rate of live births was 65.8% (262 of 398 women) in the progesterone group and 63.3% (271 of 428 women) in the placebo group (relative rate, 1.04; 95% confidence interval [CI], 0.94 to 1.15; rate difference, 2.5 percentage points; 95% CI, −4.0 to 9.0). There were no significant between-group differences in the rate of adverse events.ConclusionsProgesterone therapy in the first trimester of pregnancy did not result in a significantly higher rate of live births among women with a history of unexplained recurrent miscarriages. (Funded by the United Kingdom National Institute of Health Research; PROMISE Current Controlled Trials number, ISRCTN92644181. opens in new tab.)
AU  - Coomarasamy,A
AU  - Williams,H
AU  - Truchanowicz,E
AU  - Seed,PT
AU  - Small,R
AU  - Quenby,S
AU  - Gupta,P
AU  - Dawood,F
AU  - Koot,YEM
AU  - Atik,RB
AU  - Bloemenkamp,KWM
AU  - Brady,R
AU  - Briley,AL
AU  - Cavallaro,R
AU  - Cheong,YC
AU  - Chu,JJ
AU  - Eapen,A
AU  - Ewies,A
AU  - Hoek,A
AU  - Kaaijk,EM
AU  - Koks,CAM
AU  - Li,T-C
AU  - MacLean,M
AU  - Mol,BW
AU  - Moore,J
AU  - Ross,JA
AU  - Sharpe,L
AU  - Stewart,J
AU  - Vaithilingam,N
AU  - Farquharson,RG
AU  - Kilby,MD
AU  - Khalaf,Y
AU  - Goddijn,M
AU  - Regan,L
AU  - Rai,R
DO  - 10.1056/NEJMoa1504927
EP  - 2148
PY  - 2015///
SN  - 1533-4406
SP  - 2141
TI  - A randomized trial of progesterone in women with recurrent miscarriages
T2  - New England Journal of Medicine
UR  - http://dx.doi.org/10.1056/NEJMoa1504927
UR  - http://hdl.handle.net/10044/1/39024
VL  - 373
ER  -

Download

ProfessorLesleyRegan

Contact

Assistant

Location

Summary

Citation

BibTex format

RIS format (EndNote, RefMan)