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@article{jayasena:2016:humrep/dew225,
author = {jayasena, C and abbara, A and comninos, A and narayanaswamy and gonzalez, J and izzi-engbeaya, C and oldham, J and lee, T and sarang, Z and malik, Z and dhanjal, MK and williamson, C and regan, L and bloom, S and dhillo, W},
doi = {humrep/dew225},
journal = {Human Reproduction},
pages = {2681--2688},
title = {Novel circulating placental markers prokineticin-1, soluble fms-like tyrosine kinase-1, soluble endoglin and placental growth factor and risk of late miscarriage},
url = {http://dx.doi.org/10.1093/humrep/dew225},
volume = {31},
year = {2016}
}

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TY  - JOUR
AB  - STUDY QUESTION Are novel circulating placental markers prokineticin-1 (PK-1), soluble fms-like tyrosine kinase-1 (sFlt-1), soluble endoglin (sEng) and placental growth factor (PlGF) associated with late miscarriage in asymptomatic first trimester pregnant women?SUMMARY ANSWER Increased serum sFlt-1 or PlGF, but not sEng or PK-1, were significantly associated with reduced miscarriage risk after adjustment for age, BMI, gestational age, smoking and blood pressure.WHAT IS KNOWN ALREADY Abnormal placental development is observed in two-thirds of miscarriages. Identifying women at high risk of late miscarriage could help diagnose potentially treatable causes of miscarriage such as infection, thrombosis or immunological disease. Recently, the circulating placental markers PK-1, sFlt-1, sEng and PlGF have been identified; however, it is not known if circulating levels of these markers are associated with late miscarriage.STUDY DESIGN, SIZE, DURATION A single-centre observational cohort study with prospectively collected data was carried out at a tertiary care centre 2010–2012, in 993 asymptomatic pregnant women. Plasma PK-1, and serum sEng, sFlt-1 and PlGF were measured once in each patient during the antenatal booking visit, and pregnancy outcome was monitored prospectively. Less than 1% of patients were lost to follow-up. Multiples of median (MOM) levels were calculated to adjust for gestational age.PARTICIPANTS/MATERIALS, SETTING, METHODS Nine-hundred and ninety-three asymptomatic pregnant women attending antenatal clinic for a routine booking antenatal appointment were recruited to the study, of whom 12 were lost to follow-up and excluded from analysis. Of the cohort, 50 of the remaining 981 women suffered late miscarriage.MAIN RESULTS AND THE ROLE OF CHANCE Gestation-adjusted sEng, sFlt-1 and PlGF levels were 11% (P < 0.01), 36% (P < 0.001) and 30% (P < 0.001), respectively, lower in women who later suffered miscarriage compared with unaffected pregnanc
AU  - jayasena,C
AU  - abbara,A
AU  - comninos,A
AU  - narayanaswamy
AU  - gonzalez,J
AU  - izzi-engbeaya,C
AU  - oldham,J
AU  - lee,T
AU  - sarang,Z
AU  - malik,Z
AU  - dhanjal,MK
AU  - williamson,C
AU  - regan,L
AU  - bloom,S
AU  - dhillo,W
DO  - humrep/dew225
EP  - 2688
PY  - 2016///
SN  - 0268-1161
SP  - 2681
TI  - Novel circulating placental markers prokineticin-1, soluble fms-like tyrosine kinase-1, soluble endoglin and placental growth factor and risk of late miscarriage
T2  - Human Reproduction
UR  - http://dx.doi.org/10.1093/humrep/dew225
UR  - http://hdl.handle.net/10044/1/39007
VL  - 31
ER  -

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