Imperial College London

Dr Lynne Sykes

Faculty of MedicineDepartment of Surgery & Cancer

NIHR Clinical Lecturer



+44 (0)20 7594 2186l.sykes




3007Institute of Reproductive and Developmental BiologyHammersmith Campus





Dr Lynne Sykes is an Academic Clinical Lecturer at Imperial College Healthcare NHS Trust. Her clinical work is based at Queen Charlotte's hospital, and her research is with the Parturition Research Group led by Professor Phillip Bennett. 
Her main research interest is in the role that inflammation/infection plays in preterm labour and the adverse effects to the neonate. Her research aims are to develop new diagnostic tools and novel therapies to improve the outcome of pregnant women and their children. 
Lynne's doctoral research was under the theme of anti-inflammatories as a therapeutic strategy for the prevention of preterm labour. Her current research focuses on the immunomodulatory effects of new and existing compounds with a view to potential application in a tailored approach to women at risk of inflammation/infection induced preterm labour.  

Selected Publications

Journal Articles

Sykes L, MacIntyre DA, Yap XJ, et al., 2012, Changes in the Th1: Th2 Cytokine Bias in Pregnancy and the Effects of the Anti-Inflammatory Cyclopentenone Prostaglandin 15-Deoxy-Delta(12,14)-Prostaglandin J(2), Mediators of Inflammation, ISSN:0962-9351

Kandola MK, Sykes L, Lee YS, et al., 2014, EP2 Receptor Activates Dual G Protein Signaling Pathways that Mediate Contrasting Proinflammatory and Relaxatory Responses in Term Pregnant Human Myometrium, Endocrinology, Vol:155, ISSN:0013-7227, Pages:605-617

Sykes L, MacIntyre DA, Teoh TG, et al., 2014, Anti-inflammatory prostaglandins for the prevention of preterm labour, Reproduction, Vol:148, ISSN:1470-1626, Pages:R29-R40

Sykes L, Herbert BR, MacIntyre DA, et al., 2013, The CRTH2 agonist Pyl A prevents lipopolysaccharide-induced fetal death but induces preterm labour, Immunology, Vol:139, ISSN:0019-2805, Pages:352-365

Alabi-Isama L, Sykes L, Chandiramani M, et al., 2012, Time interval from elective removal of cervical cerclage to onset of spontaneous labour, European Journal of Obstetrics & Gynecology and Reproductive Biology, Vol:165, ISSN:0301-2115, Pages:235-238

Sykes L, MacIntyre DA, Yap XJ, et al., 2012, The Th1:Th2 Dichotomy of Pregnancy and Preterm Labour, Mediators of Inflammation, ISSN:0962-9351

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