Imperial College London

Dr Lynne Sykes

Faculty of MedicineDepartment of Metabolism, Digestion and Reproduction

Clinical Senior Lecturer



+44 (0)20 7594 2186l.sykes




3007Institute of Reproductive and Developmental BiologyHammersmith Campus





Dr Lynne Sykes is a Clinical Lecturer at the Institute of Reproductive and Developmental Biology, Imperial College London and a Consultant Obstetrician at Imperial College Healthcare NHS Trust with a specialist interest in preterm birth.

Her main research interest is in the role of inflammation/infection in spontaneous preterm labour, and has been working in this area for the last decade. Lynne's doctoral research explored the potential use of anti-inflammatory agents as a therapeutic strategy for the prevention of preterm labour.

She now leads a team who focus on the on the importance of the immune response in women who deliver preterm. One area of her work aims to decipher the role of viruses on bacterial induced preterm labour, with particular consideration to tissue dependent responses in the context of ascending versus haematogenous spread of infection. The other major part of her research is exploring patient specific immune responses to the gut and vaginal microbiota, and how this influences the risk of preterm labour. 

Her research aims are to develop predictive tools based on immuno-phenotyping, deepen understanding of how immune-microbial interactions determines the risk of preterm birth, and to develop a strategy for immunomodulation for the prevention of preterm labour.

Selected Publications

Journal Articles

Sykes L, MacIntyre DA, Teoh TG, et al., 2014, Anti-inflammatory prostaglandins for the prevention of preterm labour., Reproduction

Kandola MK, Sykes L, Lee YS, et al., 2013, EP2 Receptor Activates Dual G Protein Signaling Pathways that Mediate Contrasting Proinflammatory and Relaxatory Responses in Term Pregnant Human Myometrium, Endocrinology, Vol:Epub ahead of print

Sykes L, Herbert BR, MacIntyre DA, et al., 2013, The CRTH2 agonist Pyl A prevents LPS induced fetal death but induces preterm labour, Immunology

Alabi-Isama L, Sykes L, Chandiramani M, et al., 2012, Time interval from elective removal of cervical cerclage to onset of spontaneous labour, European Journal of Obstetrics & Gynecology and Reproductive Biology, Vol:165, ISSN:0301-2115, Pages:235-238

Sykes L, MacIntyre DA, Yap XJ, et al., 2012, The Th1:Th2 Dichotomy of Pregnancy and Preterm Labour, Mediators of Inflammation, Vol:2012, Pages:1-12

Sykes L, MacIntyre DA, Yap XJ, et al., 2012, Changes in the Th1:Th2 cytokine bias in pregnancy and the effects of the anti-inflammatory cyclopentenone prostaglandin 15-deoxy-Δ 12,14- Prostaglandin J2, Mediators of Inflammation

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