Dr Lynne Sykes is an NIHR Academic Clinical Lecturer at the Institute of Reproductive and Developmental Biology, Imperial College London. She also holds an honorary contract at Imperial College Healthcare NHS Trust where she looks after women at high risk of preterm labour.
Her main research interest is in the role of inflammation/infection in spontaneous preterm labour and the adverse effects to the neonate, and has been working in this area for the last decade. Lynne's doctoral research explored the potential use of anti-inflammatory agents as a therapeutic strategy for the prevention of preterm labour.
She now leads a team who focus on the on the importance of the immune response in women who deliver preterm. One area of her work aims to decipher the role of viruses on bacterial induced preterm labour, with particular consideration to tissue dependent responses in the context of ascending versus haematogenous spread of infection. The other major part of her research is exploring patient specific immune responses to the gut and vaginal microbiota, and how this influences the risk of preterm labour.
Her research aims are to develop predictive tools based on immuno-phenotyping, deepen understanding of how immune-microbial interactions determines the risk of preterm birth, and to develop a strategy for immunomodulation for the prevention of preterm labour.
et al., 2012, Changes in the Th1: Th2 Cytokine Bias in Pregnancy and the Effects of the Anti-Inflammatory Cyclopentenone Prostaglandin 15-Deoxy-Delta(12,14)-Prostaglandin J(2), Mediators of Inflammation, ISSN:0962-9351
et al., 2014, EP2 Receptor Activates Dual G Protein Signaling Pathways that Mediate Contrasting Proinflammatory and Relaxatory Responses in Term Pregnant Human Myometrium, Endocrinology, Vol:155, ISSN:0013-7227, Pages:605-617
et al., 2014, Anti-inflammatory prostaglandins for the prevention of preterm labour, Reproduction, Vol:148, ISSN:1470-1626, Pages:R29-R40
et al., 2013, The CRTH2 agonist Pyl A prevents lipopolysaccharide-induced fetal death but induces preterm labour, Immunology, Vol:139, ISSN:0019-2805, Pages:352-365
et al., 2012, Time interval from elective removal of cervical cerclage to onset of spontaneous labour, European Journal of Obstetrics & Gynecology and Reproductive Biology, Vol:165, ISSN:0301-2115, Pages:235-238
et al., 2012, The Th1:Th2 Dichotomy of Pregnancy and Preterm Labour, Mediators of Inflammation, ISSN:0962-9351