Plasmonic nanoparticle assembly at liquid-liquid interfaces
The three most significant challenges facing biosensing are inaccuracy, insensitivity, and low-throughput detection. One technique that is capable of facing these challenges is Surface Enhanced Raman Scattering (SERS) which has demonstrated potential for extreme sensitivity (single molecule detection) and rapid, multiple-analyte detection within complex mixtures. Early stage diagnosis of disease requires the detection of trace amounts of analyte in multi-component biological samples (blood, urine, saliva). It is therefore particularly important for sensors to reach the single-molecule detection limit. Further, the ability to analyse biological samples without separation or other treatment steps is a crucial advantage of SERS.
My approach involves the electrotuneable self-assembly of plasmonic nanoparticles at a liquid-liquid interface for SERS detection, overcoming the severe limitations of current sensors (sensitivity, specificity and speed). The positioning of nanoparticles at the interface is electrochemically controlled in a precise manner to maximise the Raman signal. Additionally I am investigating shaped nanoparticles, such as stars and ellipsoids, to exploit the enormous Raman enhancements observed at sharp metallic tips and push the sensitivity towards single-molecule detection limits. Due to the versatility of this system it can be adapted to any disease or virus where the related biomarker is known.
- Postdoctoral Research Associate, Department of Chemistry, Imperial College London. Supervisor: Dr Joshua Edel
- Postdoctoral Research Associate, Institute for Frontier Materials, Deakin University. Supervisor: Prof Lingxue Kong
- Postdoctoral Research Associate, School of Chemical and Physical Sciences, Flinders University. Supervisors: Prof Joe Shapter, Prof Justin Gooding
- PhD in Chemistry, School of Chemical and Physical Sciences, Flinders University. Supervisors: Prof Joe Shapter, Dr Dusan Losic
- BSc in Nanotechnology (Honours), Flinders University
et al., 2017, 3D Confocal Raman Tomography to Probe Field Enhancements inside Supercluster Metamaterials, Acs Photonics, Vol:4, ISSN:2330-4022, Pages:2070-2077
et al., 2017, Monitoring plasmon coupling and SERS enhancement through in situ nanoparticle spacing modulation., Faraday Discuss, Vol:205, ISSN:1359-6640, Pages:67-83
et al., 2016, Self-Assembled Spherical Supercluster Metamaterials from Nanoscale Building Blocks, Acs Photonics, Vol:3, ISSN:2330-4022, Pages:35-42
et al., 2016, Tuneable 2D self-assembly of plasmonic nanoparticles at liquid| liquid interfaces, Nanoscale, Vol:8, ISSN:2040-3364, Pages:19229-19241
et al., 2015, Fabrication of high specificity hollow mesoporous silica nanoparticles assisted by Eudragit for targeted drug delivery, Journal of Colloid and Interface Science, Vol:445, ISSN:0021-9797, Pages:151-160