Metagenomics (microbiome and virome)
Transcriptomics (prokaryote and eukaryote)
Integration of computational and classical biology to better understand diversity and functionality of the gut microbiome (in vitro and in vivo)
Effect of gut-derived microbial metabolites on host health
Coriobacteriia associated with the gut microbiota
Klebsiella pneumoniae and its bacteriophages
Dr Hoyles took her first degree in Microbiology at the University of Reading. She then trained as a taxonomist, focusing on the characterization of novel anaerobic Actinobacteria at the Institute of Food Research, Reading. Her GlaxoSmithKline-funded PhD studies at the University of Reading looked at the effect of the anti-obesity therapy Orlistat on lipid metabolism by the human gut microbiota. During her PhD, Dr Hoyles was awarded a Government of Ireland Postdoctoral Fellowship in Science, Engineering and Technology (IRCSET scheme) to develop improved methods for the isolation and characterization of gut-associated bacteriophages at University College Cork, Ireland. She was then awarded an MRC Advanced Scholarship to undertake an MSc in Bioinformatics with Theoretical Systems Biology at Imperial College London. Since qualifying as a bioinformatician, Dr Hoyles has worked in translational systems biology at Imperial College London building pipelines for the processing, analyses and integration of transcriptomic (microarray, RNA-seq; human, mouse), metagenomic (faecal; human), 16S rRNA gene (faecal; human, mouse) and metabolomic datasets. She is currently an MRC-funded Intermediate Research Fellow (UK Med-Bio), establishing a research group using classical and computational biology to examine the effects of dietary components on the microbiota, and of microbiota-derived metabolites on host health.
Dr Hoyles has set up and runs Bugs In Your Guts, a developing resource for those interested in gut microbiology and the gut microbiota, is a STEMNET Ambassador and teaches on the MRes Biomedical Research stream Microbiome in Health and Disease.
Carding SR, Davis N, Hoyles L, 2017, Review article: the human intestinal virome in health and disease., Aliment Pharmacol Ther, Vol:46, Pages:800-815
et al., 2017, Microbial-Host Co-metabolites Are Prodromal Markers Predicting Phenotypic Heterogeneity in Behavior, Obesity, and Impaired Glucose Tolerance, Cell Reports, Vol:20, ISSN:2211-1247, Pages:136-148