Imperial College London

Dr Lesley Hoyles

Faculty of MedicineDepartment of Surgery & Cancer

MRC Intermediate Fellow in Data Science
 
 
 
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Contact

 

lesley.hoyles11 Website

 
 
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Location

 

Sir Alexander Fleming BuildingSouth Kensington Campus

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Summary

 

Summary

Metagenomics (microbiome and virome)

Transcriptomics (prokaryote and eukaryote)

Integration of computational and classical biology to better understand diversity and functionality of the gut microbiome (in vitro and in vivo)

Effect of gut-derived microbial metabolites on host health

Coriobacteriia associated with the gut microbiota

Klebsiella pneumoniae and its bacteriophages


Biography

Dr Hoyles took her first degree in Microbiology at the University of Reading. She then trained as a taxonomist, focusing on the characterization of novel anaerobic Actinobacteria at the Institute of Food Research, Reading. Her GlaxoSmithKline-funded PhD studies at the University of Reading looked at the effect of the anti-obesity therapy Orlistat on lipid metabolism by the human gut microbiota. During her PhD, Dr Hoyles was awarded a Government of Ireland Postdoctoral Fellowship in Science, Engineering and Technology (IRCSET scheme) to develop improved methods for the isolation and characterization of gut-associated bacteriophages at University College Cork, Ireland. She was then awarded an MRC Advanced Scholarship to undertake an MSc in Bioinformatics with Theoretical Systems Biology at Imperial College London. Since qualifying as a bioinformatician, Dr Hoyles has worked in translational systems biology at Imperial College London building pipelines for the processing, analyses and integration of transcriptomic (microarray, RNA-seq; human, mouse), metagenomic (faecal; human), 16S rRNA gene (faecal; human, mouse) and metabolomic datasets. She is currently an MRC-funded Intermediate Research Fellow (UK Med-Bio), establishing a research group using classical and computational biology to examine the effects of dietary components on the microbiota, and of microbiota-derived metabolites on host health.

Dr Hoyles has set up and runs Bugs In Your Guts, a developing resource for those interested in gut microbiology and the gut microbiota, is a STEMNET Ambassador and teaches on the MRes Biomedical Research stream Microbiome in Health and Disease.

Selected Publications

Journal Articles

Carding SR, Davis N, Hoyles L, 2017, Review article: the human intestinal virome in health and disease., Aliment Pharmacol Ther, Vol:46, Pages:800-815

Dumas M-E, Rothwell AR, Hoyles L, et al., 2017, Microbial-Host Co-metabolites Are Prodromal Markers Predicting Phenotypic Heterogeneity in Behavior, Obesity, and Impaired Glucose Tolerance, Cell Reports, Vol:20, ISSN:2211-1247, Pages:136-148

More Publications