Metagenomics (microbiome and virome)
Transcriptomics (prokaryote and eukaryote)
Integration of computational and classical biology to better understand diversity and functionality of the gut microbiome (in vitro and in vivo)
Effect of gut-derived microbial metabolites on host health
Coriobacteriia associated with the gut microbiota
Klebsiella pneumoniae, Klebsiella oxytoca and their bacteriophages
Professor Lesley Hoyles is a microbiologist and computational biologist. The early years of her career focussed on the isolation and phenotypic characterization of novel anaerobic Actinobacteria. Her PhD studies at the University of Reading introduced Professor Hoyles to the gut microbiota, and led her to develop an interest in integrating various -omics and traditional approaches to look at microbe–host interactions and co-metabolism. After completing a Government of Ireland Postdoctoral Fellowship in Science, Engineering and Technology (IRCSET scheme) at University College Cork to develop improved methods for the isolation and characterization of gut-associated bacteriophages, Professor Hoyles was awarded an MRC Advanced Scholarship to undertake an MSc in Bioinformatics and Theoretical Systems Biology at Imperial College London. Subsequently, she worked in the field of translational systems biology at Imperial, using her unique skill set to investigate host–microbiome interactions and co-metabolism while an MRC Intermediate Research Fellow in Data Science (UK Med-Bio). Professor Hoyles currently holds a full-time position at Nottingham Trent University, and holds an honorary position at Imperial College London.