Imperial College London

Professor Lesley Hoyles

Faculty of MedicineDepartment of Surgery & Cancer

Visiting Professor
 
 
 
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Contact

 

lesley.hoyles11 Website

 
 
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Location

 

Norfolk PlaceSt Mary's Campus

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Summary

 

Summary

Metagenomics (microbiome and virome)

Transcriptomics (prokaryote and eukaryote)

Integration of computational and classical biology to better understand diversity and functionality of the gut microbiome (in vitro and in vivo)

Effect of gut-derived microbial metabolites on host health

Coriobacteriia associated with the gut microbiota

Klebsiella oxytoca complex and its bacteriophages

Biography

Professor Hoyles focuses on microbiome research. She combines microbiology and bioinformatics approaches in vitro and in vivo to understand how members of the gut microbiota function and influence human health and disease. She has specific expertise in anaerobic microbiology, and the processing and analyses of various types of omics data (microbiomic, transcriptomic, metabolomic, genomic). Using integrated systems-level approaches, Professor Hoyles has defined the contribution of the microbiome and its metabolites to non-alcoholic fatty liver diseasemetabolic retroconversion and integrity of the blood–brain barrier. Professor Hoyles currently holds a full-time position at Nottingham Trent University, and holds an honorary position within the Department of Surgery & Cancer at Imperial College London.

Selected Publications

Journal Articles

Walker AWW, Hoyles L, 2023, Human microbiome myths and misconceptions, Nature Microbiology, Vol:8, ISSN:2058-5276, Pages:1392-1396

Alexander J, Posma J, Scott A, et al., 2023, Pathobionts in the tumour microbiota predict survival following resection for colorectal cancer, Microbiome, Vol:11, ISSN:2049-2618, Pages:1-14

McCartney AL, Hoyles L, 2023, The role of Klebsiella populations in preterm infants., Biochem Soc Trans, Vol:51, Pages:887-896

Stachulski A, Knausenberger TB-A, Shah SN, et al., 2023, A host-gut microbial amino acid co-metabolite, <i>p</i>-cresol glucuronide, promotes blood-brain barrier integrity <i>in vivo</i>, Tissue Barriers, Vol:11, ISSN:2168-8370

Belda E, Voland L, Tremaroli V, et al., 2022, Impairment of gut microbial biotin metabolism and host biotin status in severe obesity: effect of biotin and prebiotic supplementation on improved metabolism, Gut, Vol:71, ISSN:0017-5749, Pages:2463-2480

Menghini R, Hoyles L, Cardellini M, et al., 2022, ITCH E3 ubiquitin ligase downregulation compromises hepatic degradation of branched-chain amino acids, Molecular Metabolism, Vol:59, ISSN:2212-8778

Fromentin S, Forslund SK, Chechi K, et al., 2022, Microbiome and metabolome features of the cardiometabolic disease spectrum, Nature Medicine, Vol:28, ISSN:1078-8956, Pages:303-+

Forslund SK, Chakaroun R, Zimmermann-Kogadeeva M, et al., 2021, Combinatorial, additive and dose-dependent drug-microbiome associations, Nature, Vol:600, ISSN:0028-0836, Pages:500-505

Hoyles L, Pontifex MG, Rodriguez-Ramiro I, et al., 2021, Regulation of blood brain barrier integrity by microbiome-associated methylamines and cognition by trimethylamine N-oxide, Microbiome, Vol:9, ISSN:2049-2618, Pages:1-21

Hoyles L, Mayneris-Perxachs J, Cardellini M, et al., 2021, ­Iron status influences non-alcoholic fatty liver disease in obesity through the gut microbiome, Microbiome, Vol:9, ISSN:2049-2618, Pages:1-18

D'Amato A, Di Cesare Mannelli L, Lucarini E, et al., 2020, Faecal microbiota transplant from aged donor mice affects spatial learning and memory via modulating hippocampal synaptic plasticity- and neurotransmission-related proteins in young recipients, Microbiome, Vol:8, ISSN:2049-2618, Pages:1-19

Kujawska M, La Rosa SL, Roger LC, et al., 2020, Succession of bifidobacterium longum strains in response to a changing early life nutritional environment reveals dietary substrate adaptations, Iscience, Vol:23, ISSN:2589-0042, Pages:1-29

Chen Y, Brook TC, Soe CZ, et al., 2020, Preterm infants harbour diverse Klebsiella populations, including atypical species that encode and produce an array of antimicrobial resistance- and virulence-associated factors, Microbial Genomics, Vol:6, ISSN:2057-5858, Pages:1-20

Leggett RM, Alcon-Giner C, Heavens D, et al., 2020, Rapid MinION profiling of preterm microbiota and antimicrobial-resistant pathogens, Nature Microbiology, Vol:5, ISSN:2058-5276, Pages:430-442

Hoyles L, Fernández-Real J-M, Federici M, et al., 2018, Molecular phenomics and metagenomics of hepatic steatosis in non-diabetic obese women., Nature Medicine, Vol:24, ISSN:1078-8956, Pages:1070-1080

Hoyles L, Jiménez-Pranteda MJ, Chilloux J, et al., 2018, Metabolic retroconversion of trimethylamine N-oxide and the gut microbiota, Microbiome, Vol:6, ISSN:2049-2618

Hoyles L, Snelling T, Umlai UK, et al., 2018, Microbiome–host systems interactions: protective effects of propionate upon the blood–brain barrier, Microbiome, Vol:6, ISSN:2049-2618

More Publications