18 results found
Li LM, Violante IR, Leech R, et al., 2019, Brain state and polarity dependent modulation of brain networks by transcranial direct current stimulation., Hum Brain Mapp, Vol: 40, Pages: 904-915
Despite its widespread use in cognitive studies, there is still limited understanding of whether and how transcranial direct current stimulation (tDCS) modulates brain network function. To clarify its physiological effects, we assessed brain network function using functional magnetic resonance imaging (fMRI) simultaneously acquired during tDCS stimulation. Cognitive state was manipulated by having subjects perform a Choice Reaction Task or being at "rest." A novel factorial design was used to assess the effects of brain state and polarity. Anodal and cathodal tDCS were applied to the right inferior frontal gyrus (rIFG), a region involved in controlling activity large-scale intrinsic connectivity networks during switches of cognitive state. tDCS produced widespread modulation of brain activity in a polarity and brain state dependent manner. In the absence of task, the main effect of tDCS was to accentuate default mode network (DMN) activation and salience network (SN) deactivation. In contrast, during task performance, tDCS increased SN activation. In the absence of task, the main effect of anodal tDCS was more pronounced, whereas cathodal tDCS had a greater effect during task performance. Cathodal tDCS also accentuated the within-DMN connectivity associated with task performance. There were minimal main effects of stimulation on network connectivity. These results demonstrate that rIFG tDCS can modulate the activity and functional connectivity of large-scale brain networks involved in cognitive function, in a brain state and polarity dependent manner. This study provides an important insight into mechanisms by which tDCS may modulate cognitive function, and also has implications for the design of future stimulation studies.
Li LM, Violante IR, Leech R, et al., 2019, Cognitive enhancement with Salience Network electrical stimulation is influenced by network structural connectivity, NEUROIMAGE, Vol: 185, Pages: 425-433, ISSN: 1053-8119
Deb S, Leeson V, Aimola L, et al., 2018, Aggression Following Traumatic brain injury: Effectiveness of Risperidone (AFTER): study protocol for a feasibility randomised controlled trial, TRIALS, Vol: 19, ISSN: 1745-6215
Feeney C, Sharp DJ, Hellyer PJ, et al., 2017, Serum Insulin-like Growth Factor-I Levels are Associated with Improved White Matter Recovery after Traumatic Brain Injury, ANNALS OF NEUROLOGY, Vol: 82, Pages: 30-43, ISSN: 0364-5134
Violante IR, Li LM, Carmichael DW, et al., 2017, Externally induced frontoparietal synchronization modulates network dynamics and enhances working memory performance, ELIFE, Vol: 6, ISSN: 2050-084X
Violante IR, Li LM, Carmichael DW, et al., 2017, Externally induced frontoparietal synchronization modulates network dynamics and enhances working memory performance., Elife, Vol: 6
Cognitive functions such as working memory (WM) are emergent properties of large-scale network interactions. Synchronisation of oscillatory activity might contribute to WM by enabling the coordination of long-range processes. However, causal evidence for the way oscillatory activity shapes network dynamics and behavior in humans is limited. Here we applied transcranial alternating current stimulation (tACS) to exogenously modulate oscillatory activity in a right frontoparietal network that supports WM. Externally induced synchronization improved performance when cognitive demands were high. Simultaneously collected fMRI data reveals tACS effects dependent on the relative phase of the stimulation and the internal cognitive processing state. Specifically, synchronous tACS during the verbal WM task increased parietal activity, which correlated with behavioral performance. Furthermore, functional connectivity results indicate that the relative phase of frontoparietal stimulation influences information flow within the WM network. Overall, our findings demonstrate a link between behavioral performance in a demanding WM task and large-scale brain synchronization.
Jamall OA, Feeney C, Zaw-Linn J, et al., 2016, Prevalence and correlates of vitamin D deficiency in adults after traumatic brain injury, CLINICAL ENDOCRINOLOGY, Vol: 85, Pages: 636-644, ISSN: 0300-0664
Li LM, Leech R, Scott G, et al., 2015, The effect of oppositional parietal transcranial direct current stimulation on lateralized brain functions, EUROPEAN JOURNAL OF NEUROSCIENCE, Vol: 42, Pages: 2904-2914, ISSN: 0953-816X
Li LM, Uehara K, Hanakawa T, 2015, The contribution of interindividual factors to variability of response in transcranial direct current stimulation studies, Frontiers in Cellular Neuroscience, Vol: 9
Li LM, Menon DK, Janowitz T, 2014, Cross-Sectional Analysis of Data from the U.S. Clinical Trials Database Reveals Poor Translational Clinical Trial Effort for Traumatic Brain Injury, Compared with Stroke, PLoS ONE, Vol: 9, Pages: e84336-e84336
Kolias AG, Li LM, Guilfoyle MR, et al., 2013, Decompressive craniectomy for acute subdural hematomas: time for a randomized trial, Acta Neurochirurgica, Vol: 155, Pages: 187-188, ISSN: 0001-6268
Li LM, Guilfoyle MR, Hutchinson PJA, 2012, Prediction of outcome and prognosis after head injury, Practical management of head and neck injury, Editors: Rosenfeld, ISBN: 978-0729539562
Kolias AG, Belli A, Li LM, et al., 2012, Primary decompressive craniectomy for acute subdural haematomas: results of an international survey, Acta Neurochirurgica, Vol: 154, Pages: 1563-1565, ISSN: 0001-6268
Li LM, Kolias AG, Guilfoyle MR, et al., 2012, Outcome following evacuation of acute subdural haematomas: a comparison of craniotomy with decompressive craniectomy, Acta Neurochirurgica, Vol: 154, Pages: 1555-1561, ISSN: 0001-6268
Li LM, Bulters DO, Kirollos RW, 2012, A mathematical model of utility for single screening of asymptomatic unruptured intracranial aneurysms at the age of 50 years, Acta Neurochirurgica, Vol: 154, Pages: 1145-1152, ISSN: 0001-6268
Li LM, Timofeev I, Czosnyka M, et al., 2010, The Surgical Approach to the Management of Increased Intracranial Pressure After Traumatic Brain Injury, Anesthesia & Analgesia, Vol: 111, Pages: 736-748, ISSN: 0003-2999
Sabir IN, Li LM, Jones VJ, et al., 2007, Criteria for arrhythmogenicity in genetically-modified Langendorff-perfused murine hearts modelling the congenital long QT syndrome type 3 and the Brugada syndrome, Pflügers Archiv - European Journal of Physiology, Vol: 455, Pages: 637-651, ISSN: 0031-6768
Sabir IN, Li LM, Grace AA, et al., 2007, Restitution analysis of alternans and its relationship to arrhythmogenicity in hypokalaemic Langendorff-perfused murine hearts, Pflügers Archiv - European Journal of Physiology, Vol: 455, Pages: 653-666, ISSN: 0031-6768
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