Imperial College London

ProfessorLuisAragon Alcaide

Faculty of MedicineInstitute of Clinical Sciences

Professor of Genetics
 
 
 
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Contact

 

+44 (0)20 3313 8013luis.aragon

 
 
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Location

 

CRB (Clinical Research Building)Hammersmith Campus

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Summary

 

Publications

Publication Type
Year
to

40 results found

Bermudez-Lopez M, Teresa Villoria M, Esteras M, Jarmuz A, Torres-Rosell J, Clemente-Blanco A, Aragon Let al., 2016, Sgs1's roles in DNA end resection, HJ dissolution, and crossover suppression require a two-step SUMO regulation dependent on Smc5/6, GENES & DEVELOPMENT, Vol: 30, Pages: 1339-1356, ISSN: 0890-9369

JOURNAL ARTICLE

Sen N, Leonard J, Torres R, Garcia-Luis J, Palou-Marin G, Aragon Let al., 2016, Physical Proximity of Sister Chromatids Promotes Top2-Dependent Intertwining, MOLECULAR CELL, Vol: 64, Pages: 134-147, ISSN: 1097-2765

JOURNAL ARTICLE

Leonard J, Sen N, Torres R, Sutani T, Jarmuz A, Shirahige K, Aragon Let al., 2015, Condensin Relocalization from Centromeres to Chromosome Arms Promotes Top2 Recruitment during Anaphase, CELL REPORTS, Vol: 13, Pages: 2336-2344, ISSN: 2211-1247

JOURNAL ARTICLE

Aragon L, Martinez-Perez E, Merkenschlager M, 2013, Condensin, cohesin and the control of chromatin states, CURRENT OPINION IN GENETICS & DEVELOPMENT, Vol: 23, Pages: 204-211, ISSN: 0959-437X

JOURNAL ARTICLE

McAleenan A, Clemente-Blanco A, Cordon-Preciado V, Sen N, Esteras M, Jarmuz A, Aragon Let al., 2013, Post-replicative repair involves separase-dependent removal of the kleisin subunit of cohesin, NATURE, Vol: 493, Pages: 250-U270, ISSN: 0028-0836

JOURNAL ARTICLE

Baxter J, Aragon L, 2012, A model for chromosome condensation based on the interplay between condensin and topoisomerase II, TRENDS IN GENETICS, Vol: 28, Pages: 110-117, ISSN: 0168-9525

JOURNAL ARTICLE

McAleenan A, Cordon-Preciado V, Clemente-Blanco A, Liu I-C, Sen N, Leonard J, Jarmuz A, Aragon Let al., 2012, SUMOylation of the alpha-Kleisin Subunit of Cohesin Is Required for DNA Damage-Induced Cohesion, CURRENT BIOLOGY, Vol: 22, Pages: 1564-1575, ISSN: 0960-9822

JOURNAL ARTICLE

Quevedo O, Garcia-Luis J, Matos-Perdomo E, Aragon L, Machin Fet al., 2012, Nondisjunction of a Single Chromosome Leads to Breakage and Activation of DNA Damage Checkpoint in G2, PLOS GENETICS, Vol: 8, ISSN: 1553-7390

JOURNAL ARTICLE

Aragon L, 2011, A Double Lock on Sister Chromatids by Cohesin, MOLECULAR CELL, Vol: 44, Pages: 5-6, ISSN: 1097-2765

JOURNAL ARTICLE

Baxter J, Sen N, Lopez Martinez V, Monturus De Carandini ME, Schvartzman JB, Diffley JFX, Aragon Let al., 2011, Positive Supercoiling of Mitotic DNA Drives Decatenation by Topoisomerase II in Eukaryotes, SCIENCE, Vol: 331, Pages: 1328-1332, ISSN: 0036-8075

JOURNAL ARTICLE

Clemente-Blanco A, Sen N, Mayan-Santos M, Sacristan MP, Graham B, Jarmuz A, Giess A, Webb E, Game L, Eick D, Bueno A, Merkenschlager M, Aragon Let al., 2011, Cdc14 phosphatase promotes segregation of telomeres through repression of RNA polymerase II transcription, NATURE CELL BIOLOGY, Vol: 13, Pages: 1450-U163, ISSN: 1465-7392

JOURNAL ARTICLE

Farmer S, San-Segundo PA, Aragon L, 2011, The Smc5-Smc6 Complex Is Required to Remove Chromosome Junctions in Meiosis, PLOS ONE, Vol: 6, ISSN: 1932-6203

JOURNAL ARTICLE

Seitan VC, Hao B, Tachibana-Konwalski K, Lavagnolli T, Mira-Bontenbal H, Brown KE, Teng G, Carroll T, Terry A, Horan K, Marks H, Adams DJ, Schatz DG, Aragon L, Fisher AG, Krangel MS, Nasmyth K, Merkenschlager Met al., 2011, A role for cohesin in T-cell-receptor rearrangement and thymocyte differentiation, NATURE, Vol: 476, Pages: 467-U126, ISSN: 0028-0836

JOURNAL ARTICLE

Aragon L, 2010, Ribosomal Genes: Safety in Numbers, CURRENT BIOLOGY, Vol: 20, Pages: R368-R370, ISSN: 0960-9822

JOURNAL ARTICLE

Baxter J, Aragón L, 2010, Physical linkages between sister chromatids and their removal during yeast chromosome segregation., Cold Spring Harb Symp Quant Biol, Vol: 75, Pages: 389-394

The fidelity of chromosome inheritance is of paramount importance to all living organisms. In eukaryotic cells, the strategy to ensure physical segregation of chromosomes to daughter cells relies on two basic steps ordered in time: an initial linkage, or cohesion, of sister chromatids and its timely and complete dissolution during anaphase. The current view is that these two basic steps are accomplished around the regulation of a protein complex called cohesin that serves as "clamp brackets" distributed at intervals throughout the genome. However, many of the DNA metabolic activities during interphase also produce physical linking of chromatids. For example, during replication, intertwines between sister chromatids are formed. Here, we review our understanding of the processes that generate physical linkages between chromatids and discuss potential mechanisms that are involved in the removal of such obstacles to the complete physical separation of chromatids at anaphase.

JOURNAL ARTICLE

Bermudez-Lopez M, Ceschia A, de Piccoli G, Colomina N, Pasero P, Aragon L, Torres-Rosell Jet al., 2010, The Smc5/6 complex is required for dissolution of DNA-mediated sister chromatid linkages, NUCLEIC ACIDS RESEARCH, Vol: 38, Pages: 6502-6512, ISSN: 0305-1048

JOURNAL ARTICLE

Mayan M, Aragon L, 2010, Cis-interactions between non-coding ribosomal spacers dependent on RNAP-II separate RNAP-I and RNAP-III transcription domains, CELL CYCLE, Vol: 9, Pages: 4328-4337, ISSN: 1538-4101

JOURNAL ARTICLE

Clemente-Blanco A, Mayan-Santos M, Schneider DA, Machin F, Jarmuz A, Tschochner H, Aragon Let al., 2009, Cdc14 inhibits transcription by RNA polymerase I during anaphase, NATURE, Vol: 458, Pages: 219-U8, ISSN: 0028-0836

JOURNAL ARTICLE

Conde F, Refolio E, Cordon-Preciado V, Cortes-Ledesma F, Aragon L, Aguilera A, San-Segundo PAet al., 2009, The Dot1 Histone Methyltransferase and the Rad9 Checkpoint Adaptor Contribute to Cohesin-Dependent Double-Strand Break Repair by Sister Chromatid Recombination in Saccharomyces cerevisiae, GENETICS, Vol: 182, Pages: 437-446, ISSN: 0016-6731

JOURNAL ARTICLE

De Piccoli G, Torres-Rosell J, Aragon L, 2009, The unnamed complex: what do we know about Smc5-Smc6?, CHROMOSOME RESEARCH, Vol: 17, Pages: 251-263, ISSN: 0967-3849

JOURNAL ARTICLE

Dulev S, Aragon L, Strunnikov A, 2008, Unreplicated DNA in mitosis precludes condensin binding and chromosome condensation in S. cerevisiae, FRONTIERS IN BIOSCIENCE, Vol: 13, Pages: 5838-5846, ISSN: 1093-9946

JOURNAL ARTICLE

Hwang J-Y, Smith S, Ceschia A, Torres-Rosell J, Aragon L, Myung Ket al., 2008, Smc5-Smc6 complex suppresses gross chromosomal rearrangements mediated by break-induced replications, DNA REPAIR, Vol: 7, Pages: 1426-1436, ISSN: 1568-7864

JOURNAL ARTICLE

Hwang J-Y, Smith S, Torres-Rosell J, Aragon L, Myung Ket al., 2008, Smc5-Smc6 regulate gross chromosomal rearrangements and mediate DNA double-strand-break repair, Joint Conference of the 33rd FEBS Congress/11th IUBMB Conference, Publisher: BLACKWELL PUBLISHING, Pages: 113-113, ISSN: 1742-464X

CONFERENCE PAPER

Parelho V, Hadjur S, Spivakov M, Leleu M, Sauer S, Gregson HC, Jarmuz A, Canzonetta C, Webster Z, Nesterova T, Cobb BS, Yokomori K, Dillon N, Aragon L, Fisher AG, Merkenschiager Met al., 2008, Cohesins functionally associate with CTCF on mammalian chromosome arms, CELL, Vol: 132, Pages: 422-433, ISSN: 0092-8674

JOURNAL ARTICLE

Torres-Rosell J, De Piccoli G, Aragon L, 2007, Can eukaryotic cells monitor the presence of unreplicated DNA?, CELL DIVISION, Vol: 2, ISSN: 1747-1028

JOURNAL ARTICLE

Torres-Rosell J, De Piccoli G, Cordon-Preciado V, Farmer S, Jamuz A, Machin F, Pasero P, Lisby M, Haber JE, Aragon Let al., 2007, Anaphase onset before complete DNA replication with intact checkpoint responses, SCIENCE, Vol: 315, Pages: 1411-1415, ISSN: 0036-8075

JOURNAL ARTICLE

Torres-Rosell J, Sunjevaric I, De Piccoli G, Sacher M, Eckert-Boulet N, Reid R, Jentsch S, Rothstein R, Aragon L, Lisby Met al., 2007, The Smc5-Smc6 complex and SUMO modification of Rad52 regulates recombinational repair at the ribosomal gene locus, NATURE CELL BIOLOGY, Vol: 9, Pages: 923-U72, ISSN: 1465-7392

JOURNAL ARTICLE

Clemente-Blanco A, Gonzalez-Novo A, Machin F, Caballero-Lima D, Aragon L, Sanchez M, de Aldana CRV, Jimenez J, Correa-Bordes Jet al., 2006, The Cdc14p phosphatase affects late cell-cycle events and morphogenesis in Candida albicans, JOURNAL OF CELL SCIENCE, Vol: 119, Pages: 1130-1143, ISSN: 0021-9533

JOURNAL ARTICLE

De Piccoli G, Cortes-Ledesma F, Ira G, Torres-Rosell J, Uhle S, Farmer S, Hwang J-Y, Machin F, Ceschia A, McAleenan A, Cordon-Preciado V, Clemente-Blanco A, Vilella-Mitjana F, Ullal P, Jarmuz A, Leitao B, Bressan D, Dotiwala F, Papusha A, Zhao X, Myung K, Haber JE, Aguilera A, Aragon Let al., 2006, Smc5-Smc6 mediate DNA double-strand-break repair by promoting sister-chromatid recombination, NATURE CELL BIOLOGY, Vol: 8, Pages: 1032-U118, ISSN: 1465-7392

JOURNAL ARTICLE

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