Imperial College London

ProfessorMauricioBarahona

Faculty of Natural SciencesDepartment of Mathematics

Chair in Biomathematics
 
 
 
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Contact

 

m.barahona Website

 
 
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Location

 

6M31Huxley BuildingSouth Kensington Campus

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Summary

 

Summary

Mauricio Barahona obtained a PhD in Theoretical Physics (Dynamical Systems) from the Massachusetts Institute of Technology (MIT) under the supervision of Steve Strogatz in the Department of Mathematics.  His thesis co-advisors were Mehran Kardar (Physics) and Terry Orlando (EECS). His thesis dealt with the spatio-temporal dynamics of networks of Josephson junctions - superconducting electronic devices that can be described as coupled nonlinear oscillators. Concurrently with his PhD work, he developed methods for nonlinear data analysis based on dynamical embeddings and time series analysis.

He then obtained Fellowships to conduct postdoctoral research, first at Stanford University and then at the California Institute of Technology. At Stanford, he worked with Mac Beasley on properties of oscillator synchronization with applications to pattern detection. At Caltech, he worked with John Doyle in the Department of Control and Dynamical Systems on rigorous bounds of model reduction techniques for dynamical systems. He also developed his research on the links between dynamics and graph-theoretical properties aimed at the analysis of network dynamics.

He joined the newly formed Department of Bioengineering at Imperial as a Lecturer in 2001 and became a Reader in Biomathematics in 2004. In 2011, he moved to the Department of Mathematics as Chair of Biomathematics. Since 2016, he is Director of the EPSRC Centre for Mathematics of Precision Healthcare.

Selected Publications

Journal Articles

Beguerisse M, Bosque G, Oyarzun DA, et al., 2018, Flux-dependent graphs for metabolic networks, Npj Systems Biology and Applications, Vol:4, ISSN:2056-7189

Hodges M, Barahona M, Yaliraki SN, 2018, Allostery and cooperativity in multimeric proteins: bond-to-bond propensities in ATCase, Scientific Reports, Vol:8, ISSN:2045-2322

Tomazou M, Barahona M, Polizzi KM, et al., 2018, Computational Re-design of Synthetic Genetic Oscillators for Independent Amplitude and Frequency Modulation, Cell Systems, Vol:6, ISSN:2405-4712, Pages:508-+

Liu Z, Barahona M, 2017, Geometric multiscale community detection: Markov stability and vector partitioning, Journal of Complex Networks, Vol:6, ISSN:2051-1329, Pages:157-172

Kiselev VY, Kirschner K, Schaub MT, et al., 2017, SC3: consensus clustering of single-cell RNA-seq data, Nature Methods, Vol:14, ISSN:1548-7091, Pages:483-+

Schaub MT, O'Clery N, Billeh YN, et al., 2016, Graph partitions and cluster synchronization in networks of oscillators, Chaos, Vol:26, ISSN:1054-1500

Kuntz J, Ottobre M, Stan G-B, et al., 2016, BOUNDING STATIONARY AVERAGES OF POLYNOMIAL DIFFUSIONS VIA SEMIDEFINITE PROGRAMMING, SIAM Journal on Scientific Computing, Vol:38, ISSN:1064-8275, Pages:A3891-A3920

Amor BRC, Schaub MT, Yaliraki S, et al., 2016, Prediction of allosteric sites and mediating interactions through bond-to-bond propensities, Nature Communications, Vol:7, ISSN:2041-1723

Dattani J, Barahona M, 2017, Stochastic models of gene transcription with upstream drives: Exact solution and sample path characterisation, Journal of the Royal Society Interface, Vol:14, ISSN:1742-5689

Bacik KA, Schaub MT, Beguerisse-Diaz M, et al., 2016, Flow-Based Network Analysis of the Caenorhabditis elegans Connectome, PLOS Computational Biology, Vol:12, ISSN:1553-734X

Beguerisse-Diaz M, McLennan AK, Garduño-Hernández G, et al., 2017, The 'who' and 'what' of #diabetes on Twitter, Digital Health, Vol:3, ISSN:2055-2076, Pages:1-29

Sim A, Yaliraki SN, Barahona M, et al., 2015, Great cities look small., Journal of the Royal Society Interface, Vol:12, ISSN:1742-5689

Noseda M, Harada M, McSweeney S, et al., 2015, PDGFRα demarcates the cardiogenic clonogenic Sca1(+) stem/progenitor cell in adult murine myocardium., Nature Communications, Vol:6, ISSN:2041-1723, Pages:6930-6930

Schaub MT, Billeh YN, Anastassiou CA, et al., 2015, Emergence of Slow-Switching Assemblies in Structured Neuronal Networks, PLOS Computational Biology, Vol:11, ISSN:1553-734X

Lambiotte R, Delvenne JC, Barahona M, 2014, Random walks, Markov processes and the multiscale modular organization of complex networks, Ieee Transactions on Network Science and Engineering, Vol:1, Pages:76-90

Wang B, Barahona M, Buck M, 2015, Amplification of small molecule-inducible gene expression via tuning of intracellular receptor densities, Nucleic Acids Research, Vol:43, ISSN:0305-1048, Pages:1955-1964

Branch T, Girvan P, Barahona M, et al., 2015, Introduction of a Fluorescent Probe to Amyloid-beta to Reveal Kinetic Insights into Its Interactions with Copper(II), Angewandte Chemie - International Edition, Vol:54, ISSN:1433-7851, Pages:1227-1230

Georgiou PS, Barahona M, Yaliraki SN, et al., 2014, On memristor ideality and reciprocity, Microelectronics Journal, Vol:45, ISSN:0026-2692, Pages:1363-1371

Billeh YN, Schaub MT, Anastassiou CA, et al., 2014, Revealing cell assemblies at multiple levels of granularity, Journal of Neuroscience Methods, Vol:236, ISSN:0165-0270, Pages:92-106

Wang B, Barahona M, Buck M, 2014, Engineering modular and tunable genetic amplifiers for scaling transcriptional signals in cascaded gene networks, Nucleic Acids Research, Vol:42, ISSN:0305-1048, Pages:9484-9492

Amor B, Yaliraki SN, Woscholski R, et al., 2014, Uncovering allosteric pathways in caspase-1 using Markov transient analysis and multiscale community detection, Molecular Biosystems, Vol:10, ISSN:1742-206X, Pages:2247-2258

Beguerisse-Díaz M, Garduño-Hernández G, Vangelov B, et al., 2014, Interest communities and flow roles in directed networks: the Twitter network of the UK riots, J. R. Soc. Interface 6 December 2014, Vol:11

Georgiou PS, Barahona M, Yaliraki SN, et al., 2012, Device Properties of Bernoulli Memristors, Proceedings of the IEEE, Vol:100, ISSN:0018-9219, Pages:1938-1950

Wang B, Barahona M, Buck M, 2013, A modular cell-based biosensor using engineered genetic logic circuits to detect and integrate multiple environmental signals, Biosensors & Bioelectronics, Vol:40, ISSN:0956-5663, Pages:368-376

Beguerisse Diaz M, Desikan R, Barahona M, 2016, Linear models of activation cascades: analytical solutions and coarse-graining of delayed signal transduction, Journal of the Royal Society Interface, Vol:13, ISSN:1742-5689

Schaub MT, Delvenne J-C, Yaliraki SN, et al., 2012, Markov Dynamics as a Zooming Lens for Multiscale Community Detection: Non Clique-Like Communities and the Field-of-View Limit, PLOS One, Vol:7, ISSN:1932-6203

Delvenne J-C, Yaliraki SN, Barahona M, 2010, Stability of graph communities across time scales, Proceedings of the National Academy of Sciences of the United States of America, Vol:107, ISSN:0027-8424, Pages:12755-12760

Strelkowa N, Barahona M, 2010, Switchable genetic oscillator operating in quasi-stable mode, Journal of the Royal Society Interface, Vol:7, ISSN:1742-5689, Pages:1071-1082

Barahona M, Poon CS, 1996, Detection of nonlinear dynamics in short, noisy time series, Nature, Vol:381, ISSN:0028-0836, Pages:215-217

Barahona M, Pecora LM, 2002, Synchronization in small-world systems, Physical Review Letters, Vol:89, ISSN:0031-9007

Chang HH, Hemberg M, Barahona M, et al., 2008, Transcriptome-wide noise controls lineage choice in mammalian progenitor cells, Nature, Vol:453, ISSN:0028-0836, Pages:544-U10

Chapters

Amor B, Vuik S, Callahan R, et al., 2016, Community detection and role identification in directed networks: understanding the Twitter network of the care.data debate, Dynamic Networks and Cyber-Security, Editor(s): Adams, Heard, World Scientific, Pages:111-136, ISBN:978-1-60558752-3

Delvenne J-C, Schaub MT, Yaliraki S, et al., 2013, The stability of a graph partition: A dynamics-based framework for community detection, Dynamics On and Of Complex Networks, Volume 2, Editor(s): Mukherjee, Choudhury, Peruani, Ganguly, Mitra, Springer, Pages:221-242, ISBN:978-1-4614-6728-1

Conference

Altuncu MT, Mayer E, Yaliraki SN, et al., From Text to Topics in Healthcare Records: An Unsupervised Graph Partitioning Methodology, 2018 KDD Conference Proceedings - MLMH: Machine Learning for Medicine and Healthcare

Jadbabaie A, Motee N, Barahona M, 2004, On the stability of the Kuramoto model of coupled nonlinear oscillators, American Control Conference, IEEE, Pages:4296-4301, ISSN:0743-1619

Patents

Poon, C.S., Barahona, M., Merrill, C.K., 1996, Method and apparatus for detecting nonlinearity in a dynamical system, US, United States Patent 5792062, World WO1997043722

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