Imperial College London

ProfessorMaria-GloriaBasanez

Faculty of MedicineSchool of Public Health

Professor of Neglected Tropical Diseases
 
 
 
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Contact

 

+44 (0)20 7594 3295m.basanez Website

 
 
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Location

 

G38Medical SchoolSt Mary's Campus

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Summary

 

Summary

Epidemiology and modelling of indirectly transmitted macroparasites

Motivation: Macroparasites are important causes of morbidity worldwide.  Apart from the direct effects of infection, they may also have immunosuppressive effects that render hosts vulnerable to more lethal pathogens.  Indirectly-transmitted helminth infections are particularly complex.  The lifecycle of these parasites involves more than one host for their transmission; the lifespan of the worms may be long in comparison to that of the hosts, and morbidity is associated with the intensity of infection.  All this poses challenging problems for the development of mathematical frameworks for their population dynamics and the effect on these dynamics of control interventions.

Human onchocerciasis, better known as ‘River blindness’ has been endemic in 34 tropical countries.  Although the Onchocerciasis Control Programme (OCP) in West Africa (1975-2002) has greatly improved the situation in its 11 participating countries, infection by Onchocerca volvulus (the causal agent of River Blindness) still poses an important public health problem in many areas of Africa, Yemen, and Latin America.  In Latin America, the Amazonian focus (between Venezuela and Brazil) has levels of infection prevalence, intensity, and transmission similar to those present in West Africa before the inception of OCP.  Onchocerciasis is one of the Neglected Tropical Diseases (NTDs).  Collectively, the NTDs impose disease burdens similar to those of HIV and Malaria.  The NTDs include the filariases, the schistosomiases, the soil-transmitted helminthiases, the trypanosomiases and leishmaniases, and bacterial infections such as trachoma, among others. 

 

 

Publications

Journals

Cucunuba ZM, Nouvellet P, Peterson JK, et al., 2018, Complementary Paths to Chagas Disease Elimination: The Impact of Combining Vector Control With Etiological Treatment, Clinical Infectious Diseases, Vol:66, ISSN:1058-4838, Pages:S293-S300

Verver S, Walker M, Kim YE, et al., 2018, How Can Onchocerciasis Elimination in Africa Be Accelerated? Modeling the Impact of Increased Ivermectin Treatment Frequency and Complementary Vector Control, Clinical Infectious Diseases, Vol:66, ISSN:1058-4838, Pages:S267-S274

Routledge I, Walker M, Cheke RA, et al., 2018, Modelling the impact of larviciding on the population dynamics and biting rates of Simulium damnosum (s.l.): implications for vector control as a complementary strategy for onchocerciasis elimination in Africa, Parasites & Vectors, Vol:11, ISSN:1756-3305

Zain SNM, Basanez M-G, 2018, Collaborate or Collapse: Capacity Building in Zoonotic and Neglected Tropical Disease Modelling, Trends in Parasitology, Vol:34, ISSN:1471-4922, Pages:356-358

Whittaker C, Walker M, Pion SDS, et al., 2018, The Population Biology and Transmission Dynamics of Loa loa, Trends in Parasitology, Vol:34, ISSN:1471-4922, Pages:335-350

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