Publications
272 results found
Walker M, Pion SD, Fang H, et al., 2015, MULTIPLE IVERMECTIN DOSES ARE MACROFILARICIDAL: IMPLICATIONS FOR THE ELIMINATION OF ONCHOCERCIASIS, Publisher: AMER SOC TROP MED & HYGIENE, Pages: 556-556, ISSN: 0002-9637
O'Hanlon S, Slater H, Cheke R, et al., 2015, MODEL-BASED GEOSTATISTICAL MAPPING OF THE PRECONTROL PREVALENCE OF <i>ONCHOCERCA VOLVULUS</i> IN WEST AFRICA, Publisher: AMER SOC TROP MED & HYGIENE, Pages: 527-527, ISSN: 0002-9637
Deol AK, Basanez M-G, Walker M, et al., 2015, COMPARISON OF FULL AGE-INTENSITY PROFILES FOR SCHISTOSOMIASIS AND SOIL-TRANSMITTED HELMINTH INFECTION FROM A TWO-YEAR STUDY IN UGANDA, Publisher: AMER SOC TROP MED & HYGIENE, Pages: 161-161, ISSN: 0002-9637
Deol AK, Basanez M-G, Walker M, et al., 2015, THE USE OF A MARKOV TRANSITION PROBABILITY MODEL AS A PROGRAMMATIC TOOL FOR THE CONTROL OF SCHISTOSOMIASIS, Publisher: AMER SOC TROP MED & HYGIENE, Pages: 558-558, ISSN: 0002-9637
Turner HC, Walker M, Lustigman S, et al., 2015, HUMAN ONCHOCERCIASIS: MODELLING THE POTENTIAL LONG-TERM CONSEQUENCES OF A VACCINATION PROGRAM, Publisher: AMER SOC TROP MED & HYGIENE, Pages: 138-138, ISSN: 0002-9637
Christiansen-Jucht C, Parham PE, Saddler A, et al., 2015, Larval and adult environmental temperatures influence the adult reproductive traits of Anopheles gambiae s.s., Parasites & Vectors, Vol: 8, ISSN: 1756-3305
BackgroundAnopheles mosquito life-history parameters and population dynamics strongly influence malaria transmission, and environmental factors, particularly temperature, strongly affect these parameters. There are currently some studies on how temperature affects Anopheles gambiae s.s. survival but very few exist examining other life-history traits. We investigate here the effect of temperature on population dynamics parameters.MethodsAnopheles gambiae s.s. immatures were reared individually at 23 ± 1 °C, 27 ± 1 °C, 31 ± 1 °C, and 35 ± 1 °C, and adults were held at their larval temperature or at one of the other temperatures. Larvae were checked every 24 h for development to the next stage and measured for size; wing length was measured as a proxy for adult size. Females were blood fed three times, and the number of females feeding and laying eggs was counted. The numbers of eggs and percentage of eggs hatched were recorded.ResultsIncreasing temperatures during the larval stages resulted in significantly smaller larvae (p = 0.005) and smaller adults (p < 0.001). Adult temperature had no effect on the time to egg laying, and the larval temperature of adults only affected the incubation period of the first egg batch. Temperature influenced the time to hatching of eggs, as well as the time to development at every stage. The number of eggs laid was highest when adults were kept at 27 °C, and lowest at 31 °C, and higher adult temperatures decreased the proportion of eggs hatching after the second and third blood meal. Higher adult temperatures significantly decreased the probability of blood feeding, but the larval temperature of adults had no influence on the probability of taking a blood meal. Differences were observed between the first, second, and third blood meal in the times to egg laying and hatching, number of eggs laid, and
Deol AK, Webster JP, Harrison W, et al., 2015, Development of a Markov transition probability model to predict changes in schistosomiasis infection following treatment, TROPICAL MEDICINE & INTERNATIONAL HEALTH, Vol: 20, Pages: 237-237, ISSN: 1360-2276
Basanez MG, Turner HC, Walker M, et al., 2015, Human Onchocerciasis: Modelling the Potential Long-term Consequences of a Vaccination Programme, PLOS Neglected Tropical Diseases, Vol: 9, ISSN: 1935-2735
BackgroundCurrently, the predominant onchocerciasis control strategy in Africa is annual mass drugadministration (MDA) with ivermectin. However, there is a consensus among the globalhealth community, supported by mathematical modelling, that onchocerciasis in Africa willnot be eliminated within proposed time frameworks in all endemic foci with only annualMDA, and novel and alternative strategies are urgently needed. Furthermore, use of MDAwith ivermectin is already compromised in large areas of central Africa co-endemic with Loaloa, and there are areas where suboptimal or atypical responses to ivermectin have beendocumented. An onchocerciasis vaccine would be highly advantageous in these areas.Methodology/Principal FindingsWe used a previously developed onchocerciasis transmission model (EPIONCHO) toinvestigate the impact of vaccination in areas where loiasis and onchocerciasis are coendemicand ivermectin is contraindicated. We also explore the potential influence of a vaccinationprogramme on infection resurgence in areas where local elimination has been successfullyachieved. Based on the age range included in the Expanded Programme onImmunization (EPI), the vaccine was assumed to target 1 to 5 year olds. Our modellingresults indicate that the deployment of an onchocerciasis vaccine would have a beneficialimpact in onchocerciasis–loiasis co-endemic areas, markedly reducing microfilarial load inthe young (under 20 yr) age groups.Conclusions/SignificanceAn onchocerciasis prophylactic vaccine would reduce the onchocerciasis disease burden inpopulations where ivermectin cannot be administered safely. Moreover, a vaccine could substantially decrease the chance of re-emergence of Onchocerca volvulus infection inareas where it is deemed that MDA with ivermectin can be stopped. Therefore, a vaccinewould protect the substantial investments made by present and past onchocerciasis controlprogrammes, decreasing the chance of disease recrudescence and offering an important
Christiansen-Jucht C, Erguler K, Shek CY, et al., 2015, Modelling Anopheles gambiae s.s. Population Dynamics with Temperature- and Age-Dependent Survival, International Journal of Environmental Research and Public Health, Vol: 12, Pages: 5975-6005, ISSN: 1660-4601
Climate change and global warming are emerging as important threats to humanhealth, particularly through the potential increase in vector- and water-borne diseases.Environmental variables are known to affect substantially the population dynamics andabundance of the poikilothermic vectors of disease, but the exact extent of this sensitivity isnot well established. Focusing on malaria and its main vector in Africa, Anopheles gambiaesensu stricto, we present a set of novel mathematical models of climate-driven mosquitopopulation dynamics motivated by experimental data suggesting that in An. gambiae,mortality is temperature and age dependent. We compared the performance of these modelsto that of a ―standard‖ model ignoring age dependence. We used a longitudinal dataset ofvector abundance over 36 months in sub-Saharan Africa for comparison between modelsthat incorporate age dependence and one that does not, and observe that age-dependentmodels consistently fitted the data better than the reference model. This highlights thatincluding age dependence in the vector component of mosquito-borne disease models maybe important to predict more reliably disease transmission dynamics. Further data and studies are needed to enable improved fitting, leading to more accurate and informativemodel predictions for the An. gambiae malaria vector as well as for other disease vectors.
Lamberton PHL, Cheke RA, Winskill P, et al., 2015, Onchocerciasis Transmission in Ghana: Persistence under Different Control Strategies and the Role of the Simuliid Vectors, PLOS Neglected Tropical Diseases, Vol: 9, ISSN: 1935-2735
Walker M, Specht S, Churcher TS, et al., 2015, Therapeutic Efficacy and Macrofilaricidal Activity of Doxycycline for the Treatment of River Blindness, CLINICAL INFECTIOUS DISEASES, Vol: 60, Pages: 1199-1207, ISSN: 1058-4838
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- Citations: 68
Cheke RA, Basanez M-G, Perry M, et al., 2015, Potential effects of warmer worms and vectors on onchocerciasis transmission in West Africa, PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES, Vol: 370, ISSN: 0962-8436
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- Citations: 31
Turner HC, Walker M, Attah SK, et al., 2015, The potential impact of moxidectin on onchocerciasis elimination in Africa: an economic evaluation based on the Phase II clinical trial data, Parasites & Vectors, Vol: 8, ISSN: 1756-3305
Basáñez M-G, Anderson RM, 2015, Mathematical Models for Neglected Tropical Diseases: Essential Tools for Control and Elimination, Part A., Adv Parasitol, Vol: 87, Pages: xiii-xvii
Cheke RA, Basanez MG, Perry M, et al., 2015, Potential effects of warmer worms and vectors on onchocerciasis transmission in West Africa, Philosophical Transactions of the Royal Society B: Biological Sciences, ISSN: 1471-2970
Walker M, Basanez M-G, Ouedraogo AL, et al., 2015, Improving statistical inference on pathogen densities estimated by quantitative molecular methods: malaria gametocytaemia as a case study, BMC BIOINFORMATICS, Vol: 16, ISSN: 1471-2105
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- Citations: 10
Gendrin M, Rodgers FH, Yerbanga RS, et al., 2015, Antibiotics in ingested human blood affect the mosquito microbiota and capacity to transmit malaria, Nature Communications, Vol: 6, Pages: 1-7, ISSN: 2041-1723
Malaria reduction is most efficiently achieved by vector control whereby human populations at high risk of contracting and transmitting the disease are protected from mosquito bites. Here, we identify the presence of antibiotics in the blood of malaria-infected people as a new risk of increasing disease transmission. We show that antibiotics in ingested blood enhance the susceptibility of Anopheles gambiae mosquitoes to malaria infection by disturbing their gut microbiota. This effect is confirmed in a semi-natural setting by feeding mosquitoes with blood of children naturally infected with Plasmodium falciparum. Antibiotic exposure additionally increases mosquito survival and fecundity, which are known to augment vectorial capacity. These findings suggest that malaria transmission may be exacerbated in areas of high antibiotic usage, and that regions targeted by mass drug administration programs against communicable diseases may necessitate increased vector control.
Basanez M-G, Anderson RM, 2015, ADVANCES IN PARASITOLOGY Mathematical Models for Neglected Tropical Diseases: Essential Tools for Control and Elimination, Part A PREFACE, Publisher: ELSEVIER ACADEMIC PRESS INC, ISBN: 978-0-12-803256-5
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- Citations: 3
Turner HC, Walker M, French MD, et al., 2014, Neglected tools for neglected diseases: mathematical models in economic evaluations, TRENDS IN PARASITOLOGY, Vol: 30, Pages: 562-570, ISSN: 1471-4922
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- Citations: 24
Lamberton PHL, Cheke RA, Walker M, et al., 2014, Onchocerciasis transmission in Ghana: biting and parous rates of host-seeking sibling species of the <i>Simulium damnosum</i> complex, PARASITES & VECTORS, Vol: 7, ISSN: 1756-3305
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- Citations: 26
Christiansen-Jucht C, Parham PE, Saddler A, et al., 2014, Temperature during larval development and adult maintenance influences the survival of <i>Anopheles gambiae</i> s.s., PARASITES & VECTORS, Vol: 7, ISSN: 1756-3305
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- Citations: 72
Walker M, Churcher TS, Basanez M-G, 2014, Models for measuring anthelmintic drug efficacy for parasitologists, TRENDS IN PARASITOLOGY, Vol: 30, Pages: 528-537, ISSN: 1471-4922
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- Citations: 17
Turner HC, Walker M, Churcher TS, et al., 2014, Reaching the London Declaration on Neglected Tropical Diseases Goals for Onchocerciasis: An Economic Evaluation of Increasing the Frequency of Ivermectin Treatment in Africa, CLINICAL INFECTIOUS DISEASES, Vol: 59, Pages: 923-932, ISSN: 1058-4838
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- Citations: 69
Hotez PJ, Alvarado M, Basanez M-G, et al., 2014, The Global Burden of Disease Study 2010: Interpretation and Implications for the Neglected Tropical Diseases, PLOS NEGLECTED TROPICAL DISEASES, Vol: 8, ISSN: 1935-2735
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- Citations: 620
Turner HC, Walker M, Churcher TS, et al., 2014, Modelling the impact of ivermectin on River Blindness and its burden of morbidity and mortality in African Savannah: EpiOncho projections, PARASITES & VECTORS, Vol: 7, ISSN: 1756-3305
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- Citations: 49
Naidoo K, Gichuhi S, Basanez M-G, et al., 2014, Prevalence and causes of vision loss in sub-Saharan Africa: 1990-2010, BRITISH JOURNAL OF OPHTHALMOLOGY, Vol: 98, Pages: 612-618, ISSN: 0007-1161
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- Citations: 61
Naidoo KS, Gichuhi S, Basanez M-G, et al., 2014, Prevalence and causes of vision loss in Sub-Saharan Africa: 1990-2010., Publisher: ASSOC RESEARCH VISION OPHTHALMOLOGY INC, ISSN: 0146-0404
Slater HC, Churcher TS, Christophides GK, et al., 2013, PLASMODIUM-ANOPHELES INTERACTIONS: UNDERSTANDING WHAT'S BEST FOR THE PARASITE AND THE MOSQUITO, Publisher: MANEY PUBLISHING, Pages: 404-405, ISSN: 2047-7724
Churcher T, Basanez M-G, Blagborough A, et al., 2013, IS PARASITE DENSITY IMPORTANT IN MALARIA TRANSMISSION?, PATHOGENS AND GLOBAL HEALTH, Vol: 107, Pages: 450-451, ISSN: 2047-7724
French MD, Churcher TS, Basanez M-G, et al., 2013, Reductions in genetic diversity of <i>Schistosoma mansoni</i> populations under chemotherapeutic pressure: the effect of sampling approach and parasite population definition, ACTA TROPICA, Vol: 128, Pages: 196-205, ISSN: 0001-706X
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- Citations: 15
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