Imperial College London
Alternate

ProfessorMaria-GloriaBasanez

Faculty of Medicine, School of Public Health

Professor of Neglected Tropical Diseases
 
 
 
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Contact

 

+44 (0)20 7594 3295m.basanez Website

 
 
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Location

 

503School of Public HealthWhite City Campus

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Summary

 

Publications

Citation

BibTex format

@article{Routledge:2018:10.1186/s13071-018-2864-y,
author = {Routledge, I and Walker, M and Cheke, R and Bhatt, S and Baleguel, Nkot P and Matthews, G and Baleguel, D and Dobson, H and Wiles, TL and Basanez, MG},
doi = {10.1186/s13071-018-2864-y},
journal = {Parasites & Vectors},
pages = {1--16},
title = {Modelling the impact of larviciding on the population dynamics and biting rates of Simulium damnosum s.l.: implications for vector control as a complementary strategy for onchocerciasis elimination in Africa},
url = {http://dx.doi.org/10.1186/s13071-018-2864-y},
volume = {11},
year = {2018}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - Background:In 2012, the World Health Organization set goals for the elimination of onchocerciasis transmission by 2020 in selected African countries. Epidemiological data and mathematical modelling have indicated that elimination may not be achieved with annual ivermectin distribution in all endemic foci. Complementary and alternative treatment strategies (ATS), including vector control, will be necessary. Implementation of vector control will require that the ecology and population dynamics of Simuliumdamnosum sensu latobe carefully considered.Methods:We adapted our previous SIMuliid POPulation dynamics (SIMPOP) model to explore the impact of larvicidal insecticides on S.damnosums.l.biting rates in different ecological contexts and to identify how frequently and for how long vector control should be continued to sustain substantive reductions in vector biting. SIMPOP was fitted to data from large-scale aerial larviciding trials in savannah sites (Ghana) and small-scale ground larviciding trials in forest areas (Cameroon). The model was validated against independent data from Burkina Faso/Côte d’Ivoire (savannah) and Bioko (forest). Scenario analysis explored the effects of ecological and programmatic factors such as pre-control daily biting rate (DBR) and larviciding scheme design on reductions and resurgences in biting rates.Results: The estimated efficacy of large-scale aerial larviciding in the savannah was greater than that of ground-based larviciding in the forest. Small changes in larvicidal efficacy can have large impacts on intervention success. At 93% larvicidal efficacy (a realistic value based on field trials), 10 consecutive weekly larvicidal treatments would reduce DBRs by 96% (e.g. from 400 to 16bites/person/day). At 70% efficacy, and for 10 weekly applications, the DBRwould decrease by 67% (e.g. from 400 to 132bites/person/day). Larviciding is more likely to succeed in areas with lower water temperatures and where blackfly species have lo
AU  - Routledge,I
AU  - Walker,M
AU  - Cheke,R
AU  - Bhatt,S
AU  - Baleguel,Nkot P
AU  - Matthews,G
AU  - Baleguel,D
AU  - Dobson,H
AU  - Wiles,TL
AU  - Basanez,MG
DO  - 10.1186/s13071-018-2864-y
EP  - 16
PY  - 2018///
SN  - 1756-3305
SP  - 1
TI  - Modelling the impact of larviciding on the population dynamics and biting rates of Simulium damnosum s.l.: implications for vector control as a complementary strategy for onchocerciasis elimination in Africa
T2  - Parasites & Vectors
UR  - http://dx.doi.org/10.1186/s13071-018-2864-y
UR  - https://parasitesandvectors.biomedcentral.com/articles/10.1186/s13071-018-2864-y
UR  - http://hdl.handle.net/10044/1/59268
VL  - 11
ER  -
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