Imperial College London
Alternate

ProfessorMaria-GloriaBasanez

Faculty of Medicine, School of Public Health

Professor of Neglected Tropical Diseases
 
 
 
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Contact

 

+44 (0)20 7594 3295m.basanez Website

 
 
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Location

 

503School of Public HealthWhite City Campus

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Summary

 

Publications

Citation

BibTex format

@article{Cucunuba:2018:cid/ciy006,
author = {Cucunuba, Perez Z and Nouvellet, P and Peterson, J and Bartsch, S and Lee, B and Dobson, A and Basanez, MG},
doi = {cid/ciy006},
journal = {Clinical Infectious Diseases},
pages = {S293--S300},
title = {Complementary paths to chagas disease elimination: the impact of combining vector control with aetiological treatment},
url = {http://dx.doi.org/10.1093/cid/ciy006},
volume = {66},
year = {2018}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - Background:The World Health Organization’s 2020 goals for Chagas disease are (1) interrupting vector-borne intradomiciliary transmission and (2) having all infected people under care in endemic countries. Insecticide spraying has proved efficacious for reaching the first goal, but active transmission remains in several regions. For the second, treatment has mostly been restricted to recently infected patients, who comprise only a small proportion of all infected individuals.Methods:We extended our previous dynamic transmission model to simulate a domestic Chagas disease transmission cycle and examined the effects of both vector control and etiological treatment on achieving the operational criterion proposed by the Pan American Health Organization for intradomiciliary, vectorial transmission interruption (ie, <2% seroprevalence in children <5 years of age).Results:Depending on endemicity, an antivectorial intervention that decreases vector density by 90% annually would achieve the transmission interruption criterion in 2–3 years (low endemicity) to >30 years (high endemicity). When this strategy is combined with annual etiological treatment in 10% of the infected human population, the seroprevalence criterion would be achieved, respectively, in 1 and 11 years.Conclusions:Combining highly effective vector control with etiological (trypanocidal) treatment in humans would substantially reduce time to transmission interruption as well as infection incidence and prevalence. However, the success of vector control may depend on prevailing vector species. It will be crucial to improve the coverage of screening programs, the performance of diagnostic tests, the proportion of people treated, and the efficacy of trypanocidal drugs. While screening and access can be incremented as part of strengthening the health systems response, improving diagnostics performance and drug efficacy will require further research.
AU  - Cucunuba,Perez Z
AU  - Nouvellet,P
AU  - Peterson,J
AU  - Bartsch,S
AU  - Lee,B
AU  - Dobson,A
AU  - Basanez,MG
DO  - cid/ciy006
EP  - 300
PY  - 2018///
SN  - 1058-4838
SP  - 293
TI  - Complementary paths to chagas disease elimination: the impact of combining vector control with aetiological treatment
T2  - Clinical Infectious Diseases
UR  - http://dx.doi.org/10.1093/cid/ciy006
UR  - http://hdl.handle.net/10044/1/55710
VL  - 66
ER  -
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