Imperial College London
Alternate

ProfessorMaria-GloriaBasanez

Faculty of Medicine, School of Public Health

Professor of Neglected Tropical Diseases
 
 
 
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Contact

 

+44 (0)20 7594 3295m.basanez Website

 
 
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Location

 

503School of Public HealthWhite City Campus

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Summary

 

Publications

Citation

BibTex format

@article{Cano:2018:10.1186/s13071-018-2655-5,
author = {Cano, J and Basáñez, M-G and O'Hanlon, SJ and Tekle, AH and Wanji, S and Zouré, HG and Rebollo, MP and Pullan, RL},
doi = {10.1186/s13071-018-2655-5},
journal = {Parasites & Vectors},
pages = {70--70},
title = {Identifying co-endemic areas for major filarial infections in sub-Saharan Africa: seeking synergies and preventing severe adverse events during mass drug administration campaigns},
url = {http://dx.doi.org/10.1186/s13071-018-2655-5},
volume = {11},
year = {2018}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - BACKGROUND: Onchocerciasis and lymphatic filariasis (LF) are major filarial infections targeted for elimination in most endemic sub-Saharan Africa (SSA) countries by 2020/2025. The current control strategies are built upon community-directed mass administration of ivermectin (CDTI) for onchocerciasis, and ivermectin plus albendazole for LF, with evidence pointing towards the potential for novel drug regimens. When distributing microfilaricides however, considerable care is needed to minimise the risk of severe adverse events (SAEs) in areas that are co-endemic for onchocerciasis or LF and loiasis. This work aims to combine previously published predictive risk maps for onchocerciasis, LF and loiasis to (i) explore the scale of spatial heterogeneity in co-distributions, (ii) delineate target populations for different treatment strategies, and (iii) quantify populations at risk of SAEs across the continent. METHODS: Geographical co-endemicity of filarial infections prior to the implementation of large-scale mass treatment interventions was analysed by combining a contemporary LF endemicity map with predictive prevalence maps of onchocerciasis and loiasis. Potential treatment strategies were geographically delineated according to the level of co-endemicity and estimated transmission intensity. RESULTS: In total, an estimated 251 million people live in areas of LF and/or onchocerciasis transmission in SSA, based on 2015 population estimates. Of these, 96 million live in areas co-endemic for both LF and onchocerciasis, providing opportunities for integrated control programmes, and 83 million live in LF-monoendemic areas potentially targetable for the novel ivermectin-diethylcarbamazine-albendazole (IDA) triple therapy. Only 4% of the at-risk population live in areas co-endemic with high loiasis transmission, representing up to 1.2 million individuals at high risk of experiencing SAEs if treated with ivermectin. In these areas, alternative treatment strategies should be ex
AU  - Cano,J
AU  - Basáñez,M-G
AU  - O'Hanlon,SJ
AU  - Tekle,AH
AU  - Wanji,S
AU  - Zouré,HG
AU  - Rebollo,MP
AU  - Pullan,RL
DO  - 10.1186/s13071-018-2655-5
EP  - 70
PY  - 2018///
SN  - 1756-3305
SP  - 70
TI  - Identifying co-endemic areas for major filarial infections in sub-Saharan Africa: seeking synergies and preventing severe adverse events during mass drug administration campaigns
T2  - Parasites & Vectors
UR  - http://dx.doi.org/10.1186/s13071-018-2655-5
UR  - https://www.ncbi.nlm.nih.gov/pubmed/29382363
UR  - http://hdl.handle.net/10044/1/56670
VL  - 11
ER  -
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