We are interested in how the molecular machinery of the cell assembles, functions, and evolves. To tackle this problem we use electron cryo-tomography, a technique that enables us to visualize this machinery inside living cells -- to resolutions capable of discerning individual proteins.
I am co-director of the Department of Life Science's MRes in Structural Molecular Biology. Please click here for more details.
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Henderson LD, Beeby M, 2018, High-Throughput Electron Cryo-tomography of Protein Complexes and Their Assembly., Methods Mol Biol, Vol:1764, Pages:29-44
et al., 2018, Bacterial Flagellins: Does Size Matter?, Trends in Microbiology, Vol:26, ISSN:0966-842X, Pages:575-581
Rossmann FM, Beeby M, 2018, Insights into the evolution of bacterial flagellar motors from high-throughput in situ electron cryotomography and subtomogram averaging, Acta Crystallographica Section D-structural Biology, Vol:74, ISSN:2059-7983, Pages:585-594
Chaban B, Coleman I, Beeby M, 2018, Evolution of higher torque in Campylobacter-type bacterial flagellar motors, Scientific Reports, Vol:8, ISSN:2045-2322
et al., 2017, Short FtsZ filaments can drive asymmetric cell envelope constriction at the onset of bacterial cytokinesis, Embo Journal, Vol:36, ISSN:0261-4189, Pages:1577-1589