Imperial College London

DrMorganBeeby

Faculty of Natural SciencesDepartment of Life Sciences

Senior Lecturer
 
 
 
//

Contact

 

+44 (0)20 7594 5251m.beeby Website

 
 
//

Location

 

502Sir Ernst Chain BuildingSouth Kensington Campus

//

Summary

 

Publications

Publication Type
Year
to

40 results found

Nguyen LT, Oikonomou CM, Ding HJ, Kaplan M, Yao Q, Chang Y-W, Beeby M, Jensen GJet al., 2019, Simulations suggest a constrictive force is required for Gram-negative bacterial cell division, NATURE COMMUNICATIONS, Vol: 10, ISSN: 2041-1723

JOURNAL ARTICLE

Ferreira JL, Gao FZ, Rossmann FM, Nans A, Brenzinger S, Hosseini R, Wilson A, Briegel A, Thormann KM, Rosenthal PB, Beeby Met al., 2019, -proteobacteria eject their polar flagella under nutrient depletion, retaining flagellar motor relic structures, PLOS BIOLOGY, Vol: 17, ISSN: 1544-9173

JOURNAL ARTICLE

Thomson NM, Ferreira JL, Matthews-Palmer TR, Beeby M, Pallen MJet al., 2018, Giant flagellins form thick flagellar filaments in two species of marine gamma-proteobacteria, PLOS ONE, Vol: 13, ISSN: 1932-6203

JOURNAL ARTICLE

Thomson NM, Rossmann FM, Ferreira JL, Matthews-Palmer TR, Beeby M, Pallen MJet al., 2018, Bacterial Flagellins: Does Size Matter?, TRENDS IN MICROBIOLOGY, Vol: 26, Pages: 575-581, ISSN: 0966-842X

JOURNAL ARTICLE

Rossmann FM, Beeby M, 2018, Insights into the evolution of bacterial flagellar motors from high-throughput in situ electron cryotomography and subtomogram averaging, ACTA CRYSTALLOGRAPHICA SECTION D-STRUCTURAL BIOLOGY, Vol: 74, Pages: 585-594, ISSN: 2059-7983

JOURNAL ARTICLE

Chaban B, Coleman I, Beeby M, 2018, Evolution of higher torque in Campylobacter-type bacterial flagellar motors, SCIENTIFIC REPORTS, Vol: 8, ISSN: 2045-2322

JOURNAL ARTICLE

Henderson LD, Beeby M, 2018, High-Throughput Electron Cryo-tomography of Protein Complexes and Their Assembly., Methods Mol Biol, Vol: 1764, Pages: 29-44

Electron cryo-tomography and subtomogram averaging enable visualization of protein complexes in situ, in three dimensions, in a near-native frozen-hydrated state to nanometer resolutions. To achieve this, intact cells are vitrified and imaged over a range of tilts within an electron microscope. These images can subsequently be reconstructed into a three-dimensional volume representation of the sample cell. Because complexes are visualized in situ, crucial insights into their mechanism, assembly process, and dynamic interactions with other proteins become possible. To illustrate the electron cryo-tomography workflow for visualizing protein complexes in situ, we describe our workflow of preparing samples, imaging, and image processing using Leginon for data collection, IMOD for image reconstruction, and PEET for subtomogram averaging.

JOURNAL ARTICLE

Ferreira J, Matthews-Palmer T, Beeby M, 2017, Electron cryo-tomography, Cellular Imaging Electron Tomography and Related Techniques, Editors: Hanssen, Publisher: Springer, ISBN: 9783319689975

This book highlights important techniques for cellular imaging and covers the basics and applications of electron tomography and related techniques.

BOOK CHAPTER

Asmar AT, Ferreira JL, Cohen EJ, Cho S-H, Beeby M, Hughes KT, Collet J-Fet al., 2017, Communication across the bacterial cell envelope depends on the size of the periplasm, PLOS BIOLOGY, Vol: 15, ISSN: 1545-7885

JOURNAL ARTICLE

Thomson NM, Ferreira J, Matthews-Palmer T, Beeby M, Pallen Met al., 2017, Giant flagellins form thick flagellar filaments in two species of marine γ-proteobacteria

Flagella, the primary means of motility in bacteria, are helical filaments that function as microscopic propellers composed of thousands of copies of the protein flagellin. Here, we show that many bacteria encode `giant' flagellins, greater than a thousand amino acids in length, and that two species that encode giant flagellins, the marine γ-proteobacteria Bermanella marisrubri and Oleibacter marinus, produce monopolar flagellar filaments considerably thicker than filaments composed of shorter flagellin monomers. We confirm that the flagellum from B. marisrubri is built from its giant flagellin. Phylogenetic analysis reveals that the mechanism of evolution of giant flagellins has followed a stepwise process involving an internal domain duplication followed by insertion of an additional novel insert. This work illustrates how `the' bacterial flagellum should not be seen as a single, idealised structure, but as a continuum of evolved machines adapted to a range of niches.

WORKING PAPER

Yao Q, Jewett AI, Chang Y-W, Oikonomou CM, Beeby M, Iancu CV, Briegel A, Ghosal D, Jensen GJet al., 2017, Short FtsZ filaments can drive asymmetric cell envelope constriction at the onset of bacterial cytokinesis, EMBO JOURNAL, Vol: 36, Pages: 1577-1589, ISSN: 0261-4189

JOURNAL ARTICLE

Cohen EJ, Ferreira JL, Ladinsky MS, Beeby M, Hughes KTet al., 2017, Nanoscale-length control of the flagellar driveshaft requires hitting the tethered outer membrane, SCIENCE, Vol: 356, Pages: 197-200, ISSN: 0036-8075

JOURNAL ARTICLE

Hoffmann L, Schummer A, Reimann J, Haurat MF, Wilson AJ, Beeby M, Warscheid B, Albers S-Vet al., 2017, Expanding the archaellum regulatory network - the eukaryotic protein kinases ArnC and ArnD influence motility of Sulfolobus acidocaldarius, MICROBIOLOGYOPEN, Vol: 6, ISSN: 2045-8827

JOURNAL ARTICLE

Haurat MF, Figueiredo AS, Hoffmann L, Li L, Herr K, Wilson AJ, Beeby M, Schaber J, Albers S-Vet al., 2017, ArnS, a kinase involved in starvation-induced archaellum expression, MOLECULAR MICROBIOLOGY, Vol: 103, Pages: 181-194, ISSN: 0950-382X

JOURNAL ARTICLE

Taylor WR, Matthews-Palmer TRS, Beeby M, 2016, Molecular Models for the Core Components of the Flagellar Type-III Secretion Complex, PLOS ONE, Vol: 11, ISSN: 1932-6203

JOURNAL ARTICLE

Beeby M, Ribardo DA, Brennan CA, Ruby EG, Jensen GJ, Hendrixson DRet al., 2016, Diverse high-torque bacterial flagellar motors assemble wider stator rings using a conserved protein scaffold, PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, Vol: 113, Pages: E1917-E1926, ISSN: 0027-8424

JOURNAL ARTICLE

Nguyen LT, Swulius M, Gumbart JC, Beeby M, Jensen GJet al., 2016, Coarse-Grained Simulations Reveal Mechanisms of Bacterial Morphogenesis, 60th Annual Meeting of the Biophysical-Society, Publisher: CELL PRESS, Pages: 468A-468A, ISSN: 0006-3495

CONFERENCE PAPER

Oikonomou CM, Swulius MT, Briegel A, Beeby M, Yao Q, Chang Y-W, Jensen GJet al., 2016, Electron cryotomography, IMAGING BACTERIAL MOLECULES, STRUCTURES AND CELLS, Editors: Harwood, Jensen, Publisher: ELSEVIER ACADEMIC PRESS INC, Pages: 115-139

BOOK CHAPTER

Beeby M, 2015, Motility in the epsilon-proteobacteria, CURRENT OPINION IN MICROBIOLOGY, Vol: 28, Pages: 115-121, ISSN: 1369-5274

JOURNAL ARTICLE

Chaban B, Hughes HV, Beeby M, 2015, The flagellum in bacterial pathogens: For motility and a whole lot more, SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY, Vol: 46, Pages: 91-103, ISSN: 1084-9521

JOURNAL ARTICLE

Nguyen LT, Gumbart JC, Beeby M, Jensen GJet al., 2015, Coarse-grained simulations of bacterial cell wall growth reveal that local coordination alone can be sufficient to maintain rod shape, PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, Vol: 112, Pages: E3689-E3698, ISSN: 0027-8424

JOURNAL ARTICLE

Mueller A, Beeby M, McDowall AW, Chow J, Jensen GJ, Clemons WMet al., 2014, Ultrastructure and complex polar architecture of the human pathogen Campylobacter jejuni, MICROBIOLOGYOPEN, Vol: 3, Pages: 702-710, ISSN: 2045-8827

JOURNAL ARTICLE

Beeby M, 2014, Evolution of Novel Components of the Bacterial Flagellar Motor, 28th Annual Symposium of the Protein-Society, Publisher: WILEY-BLACKWELL, Pages: 61-61, ISSN: 0961-8368

CONFERENCE PAPER

Gumbart JC, Beeby M, Jensen GJ, Roux Bet al., 2014, Escherichia coli Peptidoglycan Structure and Mechanics as Predicted by Atomic-Scale Simulations, PLOS COMPUTATIONAL BIOLOGY, Vol: 10

JOURNAL ARTICLE

Beeby M, Gumbart JC, Roux B, Jensen GJet al., 2013, Architecture and assembly of the Gram-positive cell wall, MOLECULAR MICROBIOLOGY, Vol: 88, Pages: 664-672, ISSN: 0950-382X

JOURNAL ARTICLE

Jensen G, Briegel A, Beeby M, 2013, Visualizing large macromolecular assemblies in vivo with electron cryotomography, 245th National Spring Meeting of the American-Chemical-Society (ACS), Publisher: AMER CHEMICAL SOC, ISSN: 0065-7727

CONFERENCE PAPER

Abrusci P, Vergara-Irigaray M, Johnson S, Beeby MD, Hendrixson DR, Roversi P, Friede ME, Deane JE, Jensen GJ, Tang CM, Lea SMet al., 2013, Architecture of the major component of the type III secretion system export apparatus, NATURE STRUCTURAL & MOLECULAR BIOLOGY, Vol: 20, Pages: 99-U126, ISSN: 1545-9993

JOURNAL ARTICLE

Beeby M, Cho M, Stubbe J, Jensen GJet al., 2012, Growth and Localization of Polyhydroxybutyrate Granules in Ralstonia eutropha, JOURNAL OF BACTERIOLOGY, Vol: 194, Pages: 1092-1099, ISSN: 0021-9193

JOURNAL ARTICLE

Briegel A, Beeby M, Thanbichler M, Jensen GJet al., 2011, Activated chemoreceptor arrays remain intact and hexagonally packed, MOLECULAR MICROBIOLOGY, Vol: 82, Pages: 748-757, ISSN: 0950-382X

JOURNAL ARTICLE

Chen S, Beeby M, Murphy GE, Leadbetter JR, Hendrixson DR, Briegel A, Li Z, Shi J, Tocheva EI, Mueller A, Dobro MJ, Jensen GJet al., 2011, Structural diversity of bacterial flagellar motors, EMBO JOURNAL, Vol: 30, Pages: 2972-2981, ISSN: 0261-4189

JOURNAL ARTICLE

This data is extracted from the Web of Science and reproduced under a licence from Thomson Reuters. You may not copy or re-distribute this data in whole or in part without the written consent of the Science business of Thomson Reuters.

Request URL: http://wlsprd.imperial.ac.uk:80/respub/WEB-INF/jsp/search-html.jsp Request URI: /respub/WEB-INF/jsp/search-html.jsp Query String: respub-action=search.html&id=00340088&limit=30&person=true