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@unpublished{Thomson:2017:10.1101/221366,
author = {Thomson, NM and Ferreira, JL and Matthews-Palmer, TR and Beeby, M and Pallen, MJ},
doi = {10.1101/221366},
title = {Giant flagellins form thick flagellar filaments in two species of marine γ-proteobacteria},
url = {http://dx.doi.org/10.1101/221366},
year = {2017}
}

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TY  - UNPB
AB  - <jats:title>Abstract</jats:title><jats:p>Flagella, the primary means of motility in bacteria, are helical filaments that function as microscopic propellers composed of thousands of copies of the protein flagellin. Here, we show that many bacteria encode “giant” flagellins, greater than a thousand amino acids in length, and that two species that encode giant flagellins, the marine γ- proteobacteria <jats:italic>Bermanella marisrubri</jats:italic> and <jats:italic>Oleibacter marinus</jats:italic>, produce monopolar flagellar filaments considerably thicker than filaments composed of shorter flagellin monomers. We confirm that the flagellum from <jats:italic>B. marisrubri</jats:italic> is built from its giant flagellin. Phylogenetic analysis reveals that the mechanism of evolution of giant flagellins has followed a stepwise process involving an internal domain duplication followed by insertion of an additional novel insert. This work illustrates how “the” bacterial flagellum should not be seen as a single, idealised structure, but as a continuum of evolved machines adapted to a range of niches.</jats:p>
AU  - Thomson,NM
AU  - Ferreira,JL
AU  - Matthews-Palmer,TR
AU  - Beeby,M
AU  - Pallen,MJ
DO  - 10.1101/221366
PY  - 2017///
TI  - Giant flagellins form thick flagellar filaments in two species of marine γ-proteobacteria
UR  - http://dx.doi.org/10.1101/221366
ER  -

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