Imperial College London
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DrMorganBeeby

Faculty of Natural Sciences, Department of Life Sciences

Reader in Structural Biology
 
 
 
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Contact

 

m.beeby Website

 
 
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Location

 

502Sir Ernst Chain BuildingSouth Kensington Campus

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Summary

 

Publications

Citation

BibTex format

@article{Chaban:2018:10.1038/s41598-017-18115-1,
author = {Chaban, B and Coleman, I and Beeby, M},
doi = {10.1038/s41598-017-18115-1},
journal = {Scientific Reports},
title = {Evolution of higher torque in Campylobacter-type bacterial flagellar motors},
url = {http://dx.doi.org/10.1038/s41598-017-18115-1},
volume = {8},
year = {2018}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - Understanding the evolution of molecular machines underpins our understanding of the development of life on earth. A well-studied case are bacterial flagellar motors that spin helical propellers for bacterial motility. Diverse motors produce different torques, but how this diversity evolved remains unknown. To gain insights into evolution of the high-torque ε-proteobacterial motor exemplified by the Campylobacter jejuni motor, we inferred ancestral states by combining phylogenetics, electron cryotomography, and motility assays to characterize motors from Wolinella succinogenes, Arcobacter butzleri and Bdellovibrio bacteriovorus. Observation of ~12 stator complexes in many proteobacteria, yet ~17 in ε-proteobacteria suggest a “quantum leap” evolutionary event. Campylobacter-type motors have high stator occupancy in wider rings of additional stator complexes that are scaffolded by large proteinaceous periplasmic rings. We propose a model for motor evolution wherein independent inner- and outer-membrane structures fused to form a scaffold for additional stator complexes. Significantly, inner- and outer-membrane associated structures have evolved independently multiple times, suggesting that evolution of such structures is facile and poised the ε-proteobacteria to fuse them to form the high-torque Campylobacter-type motor.
AU  - Chaban,B
AU  - Coleman,I
AU  - Beeby,M
DO  - 10.1038/s41598-017-18115-1
PY  - 2018///
SN  - 2045-2322
TI  - Evolution of higher torque in Campylobacter-type bacterial flagellar motors
T2  - Scientific Reports
UR  - http://dx.doi.org/10.1038/s41598-017-18115-1
UR  - http://hdl.handle.net/10044/1/54520
VL  - 8
ER  -
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