Imperial College London
Alternate

ProfessorMartaBlangiardo

Faculty of Medicine, School of Public Health

Chair in Biostatistics
 
 
 
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Contact

 

m.blangiardo Website

 
 
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Location

 

705School of Public HealthWhite City Campus

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Summary

 

Publications

Citation

BibTex format

@article{Cai:2016:10.1183/13993003.02127-2015,
author = {Cai, Y and Zijlema, WL and Doiron, D and Blangiardo, M and Burton, PR and Fortier, I and Gaye, A and Gulliver, J and de, Hoogh K and Hveem, K and Mbatchou, S and Morley, DW and Stolk, RP and Elliott, P and Hansell, AL and Hodgson, S},
doi = {10.1183/13993003.02127-2015},
journal = {European Respiratory Journal},
title = {Ambient air pollution, traffic noise and adult asthma prevalence: a BioSHaRE approach},
url = {http://dx.doi.org/10.1183/13993003.02127-2015},
volume = {49},
year = {2016}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - We investigated the effects of both ambient air pollution and traffic noise on adult asthma prevalence, using harmonised data from three European cohort studies established in 2006–2013 (HUNT3, Lifelines and UK Biobank).Residential exposures to ambient air pollution (particulate matter with aerodynamic diameter <=10 µm (PM10) and nitrogen dioxide (NO2)) were estimated by a pan-European Land Use Regression model for 2007. Traffic noise for 2009 was modelled at home addresses by adapting a standardised noise assessment framework (CNOSSOS-EU). A cross-sectional analysis of 646 731 participants aged >=20 years was undertaken using DataSHIELD to pool data for individual-level analysis via a “compute to the data” approach. Multivariate logistic regression models were fitted to assess the effects of each exposure on lifetime and current asthma prevalence.PM10 or NO2 higher by 10 µg·m-3 was associated with 12.8% (95% CI 9.5–16.3%) and 1.9% (95% CI 1.1–2.8%) higher lifetime asthma prevalence, respectively, independent of confounders. Effects were larger in those aged >=50 years, ever-smokers and less educated. Noise exposure was not significantly associated with asthma prevalence.This study suggests that long-term ambient PM10 exposure is associated with asthma prevalence in western European adults. Traffic noise is not associated with asthma prevalence, but its potential to impact on asthma exacerbations needs further investigation.Long-term ambient PM10 exposure is associated with asthma prevalence in three European adult cohorts http://ow.ly/En4b3049S7X
AU  - Cai,Y
AU  - Zijlema,WL
AU  - Doiron,D
AU  - Blangiardo,M
AU  - Burton,PR
AU  - Fortier,I
AU  - Gaye,A
AU  - Gulliver,J
AU  - de,Hoogh K
AU  - Hveem,K
AU  - Mbatchou,S
AU  - Morley,DW
AU  - Stolk,RP
AU  - Elliott,P
AU  - Hansell,AL
AU  - Hodgson,S
DO  - 10.1183/13993003.02127-2015
PY  - 2016///
SN  - 0903-1936
TI  - Ambient air pollution, traffic noise and adult asthma prevalence: a BioSHaRE approach
T2  - European Respiratory Journal
UR  - http://dx.doi.org/10.1183/13993003.02127-2015
UR  - http://hdl.handle.net/10044/1/41886
VL  - 49
ER  -
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