Imperial College London

ProfessorMarinaBotto

Faculty of MedicineDepartment of Medicine

Director of Bioservices, Professor of Rheumatology
 
 
 
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Contact

 

+44 (0)20 3313 2316m.botto Website

 
 
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Assistant

 

Miss Claudia Rocchi +44 (0)20 3313 2315

 
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Location

 

9N10Commonwealth BuildingHammersmith Campus

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Summary

 

Publications

Publication Type
Year
to

198 results found

Crawford G, Hayes MD, Seoane RC, Ward S, Dalessandri T, Lai C, Healy E, Kipling D, Proby C, Moyes C, Green K, Best K, Haniffa M, Botto M, Dunn-Walters D, Strid Jet al., 2018, Epithelial damage and tissue gamma delta T cells promote a unique tumor-protective IgE response, NATURE IMMUNOLOGY, Vol: 19, Pages: 859-+, ISSN: 1529-2908

JOURNAL ARTICLE

Griffiths MR, Botto M, Morgan BP, Neal JW, Gasque Pet al., 2018, CD93 regulates central nervous system inflammation in two mouse models of autoimmune encephalomyelitis., Immunology

Microglia and non-professional immune cells (endothelial cells, neurons) participate in the recognition and removal of pathogens and tissue debris in the injured central nervous system through major pro-inflammatory processes. However, the mechanisms involved in regulating these responses remain ill-characterized. We herein show that CD93, also known as complement C1qRp/AA4 stem cell marker, has an important role in the regulation of inflammatory processes. The role of CD93 was evaluated in two models of neuroinflammation. We used the MOG-experimental autoimmune encephalomyelitis (EAE) model and the antibody-dependent EAE (ADEAE), which were induced in wild-type and CD93 knockout mice. We found that CD93 was highly expressed by neurons, endothelial cells and microglia (ramified > amoeboid). Astrocytes and oligodendrocytes did not to express CD93. We further observed that CD93-deficient (CD93-/- ) mice presented a more robust brain and spinal cord inflammation in EAE and ADEAE. Encephalitis in CD93-/- was characterized by increased numbers of infiltrating M1 macrophages (CD11c+ CD206- ) and amoeboid microglia exhibiting a more activated phenotype (Tomato Lectinhigh Cox2high ). Damage to and leakage through the blood-brain barrier was increased in CD93-/- animals and was associated with a more robust neuronal injury when compared with wild-type EAE mice. We propose that CD93 is an important neuro-immune regulator to control central nervous system inflammation.

JOURNAL ARTICLE

Halim TYF, Rana BMJ, Walker JA, Kerscher B, Knolle MD, Jolin HE, Serrao EM, Haim-Vilmovsky L, Teichmann SA, Rodewald H-R, Botto M, Vyse TJ, Fallon PG, Li Z, Withers DR, McKenzie ANJet al., 2018, Tissue-Restricted Adaptive Type 2 Immunity Is Orchestrated by Expression of the Costimulatory Molecule OX40L on Group 2 Innate Lymphoid Cells, IMMUNITY, Vol: 48, Pages: 1195-+, ISSN: 1074-7613

JOURNAL ARTICLE

Ling GS, Crawford G, Buang N, Bartok I, Tian K, Thielens NM, Bally I, Harker JA, Ashton-Rickardt PG, Rutschmann S, Strid J, Botto Met al., 2018, C1q restrains autoimmunity and viral infection by regulating CD8(+) T cell metabolism, SCIENCE, Vol: 360, Pages: 558-563, ISSN: 0036-8075

JOURNAL ARTICLE

Saja MF, Cook HT, Ruseva MM, Szajna M, Pickering MC, Woollard KJ, Botto Met al., 2018, A triglyceride-rich lipoprotein environment exacerbates renal injury in the accelerated nephrotoxic nephritis model, CLINICAL AND EXPERIMENTAL IMMUNOLOGY, Vol: 192, Pages: 337-347, ISSN: 0009-9104

JOURNAL ARTICLE

Tanigaki K, Sacharidou A, Peng J, Chambliss KL, Yuhanna IS, Ghosh D, Ahmed M, Szalai AJ, Vongpatanasin W, Mattrey RF, Chen Q, Azadi P, Lingvay I, Botto M, Holland WL, Kohler JJ, Sirsi SR, Hoyt K, Shaul PW, Mineo Cet al., 2018, Hyposialylated IgG activates endothelial IgG receptor Fc gamma RIIB to promote obesity-induced insulin resistance, JOURNAL OF CLINICAL INVESTIGATION, Vol: 128, Pages: 309-322, ISSN: 0021-9738

JOURNAL ARTICLE

Cortini A, Ellinghaus U, Malik TH, Graham DSC, Botto M, Vyse TJet al., 2017, B cell OX40L supports T follicular helper cell development and contributes to SLE pathogenesis, ANNALS OF THE RHEUMATIC DISEASES, Vol: 76, Pages: 2095-2103, ISSN: 0003-4967

JOURNAL ARTICLE

Giacomassi C, Buang N, Ling GS, Crawford G, Cook HT, Scott D, Dazzi F, Strid J, Botto Met al., 2017, Complement C3 Exacerbates Imiquimod-Induced Skin Inflammation and Psoriasiform Dermatitis, JOURNAL OF INVESTIGATIVE DERMATOLOGY, Vol: 137, Pages: 760-763, ISSN: 0022-202X

JOURNAL ARTICLE

Kiriakidis S, Hoer SS, Burrows N, Biddlecome G, Khan MN, Thinnes CC, Schofield CJ, Rogers N, Botto M, Paleolog E, Maxwell PHet al., 2017, Complement C1q is hydroxylated by collagen prolyl 4 hydroxylase and is sensitive to off-target inhibition by prolyl hydroxylase domain inhibitors that stabilize hypoxia-inducible factor, KIDNEY INTERNATIONAL, Vol: 92, Pages: 900-908, ISSN: 0085-2538

JOURNAL ARTICLE

Lynskey NN, Reglinski M, Calay D, Siggins MK, Mason JC, Botto M, Sriskandan Set al., 2017, Multi-functional mechanisms of immune evasion by the streptococcal complement inhibitor C5a peptidase, PLOS PATHOGENS, Vol: 13, ISSN: 1553-7366

JOURNAL ARTICLE

Muehlfeld C, Madsen J, Mackay R-M, Schneider JP, Schipke J, Lutz D, Birkelbach B, Knudsen L, Botto M, Ochs M, Clark Het al., 2017, Effect of irradiation/bone marrow transplantation on alveolar epithelial type II cells is aggravated in surfactant protein D deficient mice, HISTOCHEMISTRY AND CELL BIOLOGY, Vol: 147, Pages: 49-61, ISSN: 0948-6143

JOURNAL ARTICLE

Stratigou V, Doyle AF, Carlucci F, Stephens L, Foschi V, Castelli M, McKenna N, Cook HT, Lightstone L, Cairns TD, Pickering MC, Botto Met al., 2017, Altered expression of signalling lymphocyte activation molecule receptors in T-cells from lupus nephritis patients-a potential biomarker of disease activity, RHEUMATOLOGY, Vol: 56, Pages: 1206-1216, ISSN: 1462-0324

JOURNAL ARTICLE

Barbour TD, Ling GS, Ruseva MM, Fossati-Jimack L, Cook HT, Botto M, Pickering MCet al., 2016, Complement receptor 3 mediates renal protection in experimental C3 glomerulopathy, KIDNEY INTERNATIONAL, Vol: 89, Pages: 823-832, ISSN: 0085-2538

JOURNAL ARTICLE

Bulla R, Tripodo C, Rami D, Ling GS, Agostinis C, Guarnotta C, Zorzet S, Durigutto P, Botto M, Tedesco Fet al., 2016, C1q acts in the tumour microenvironment as a cancer-promoting factor independently of complement activation, NATURE COMMUNICATIONS, Vol: 7, ISSN: 2041-1723

JOURNAL ARTICLE

Carlucci F, Ishaque A, Ling GS, Szajna M, Sandison A, Donatien P, Cook HT, Botto Met al., 2016, C1q Modulates the Response to TLR7 Stimulation by Pristane-Primed Macrophages: Implications for Pristane-Induced Lupus, JOURNAL OF IMMUNOLOGY, Vol: 196, Pages: 1488-1494, ISSN: 0022-1767

JOURNAL ARTICLE

Scott D, Botto M, 2016, The paradoxical roles of C1q and C3 in autoimmunity., Immunobiology, Vol: 221, Pages: 719-725

In this review we will focus on the links between complement and autoimmune diseases and will highlight how animal models have provided insights into the manner by which C1q and C3 act to modulate both adaptive and innate immune responses. In particular we will highlight how C1q may not only act as initiator of the classical complement pathway, but can also mediate multiple immune responses in a complement activation independent manner.

JOURNAL ARTICLE

Vernon KA, Ruseva MM, Cook HT, Botto M, Malik TH, Pickering MCet al., 2016, Partial Complement Factor H Deficiency Associates with C3 Glomerulopathy and Thrombotic Microangiopathy, JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY, Vol: 27, Pages: 1334-1342, ISSN: 1046-6673

JOURNAL ARTICLE

Wang Y, Jenkins SA, Gu C, Shree A, Martinez-Moczygemba M, Herold J, Botto M, Wetsel RA, Xu Yet al., 2016, Bacillus anthracis Spore Surface Protein BclA Mediates Complement Factor H Binding to Spores and Promotes Spore Persistence, PLOS PATHOGENS, Vol: 12, ISSN: 1553-7366

JOURNAL ARTICLE

Ambrose N, Khan E, Ravindran R, Lightstone L, Abraham S, Botto M, Johns M, Haskard DOet al., 2015, The exaggerated inflammatory response in Behcet's syndrome: identification of dysfunctional post-transcriptional regulation of the IFN-gamma/CXCL10 IP-10 pathway, CLINICAL AND EXPERIMENTAL IMMUNOLOGY, Vol: 181, Pages: 427-433, ISSN: 0009-9104

JOURNAL ARTICLE

Clarke AJ, Ellinghaus U, Cortini A, Stranks A, Simon AK, Botto M, Vyse TJet al., 2015, Autophagy is activated in systemic lupus erythematosus and required for plasmablast development, ANNALS OF THE RHEUMATIC DISEASES, Vol: 74, Pages: 912-920, ISSN: 0003-4967

JOURNAL ARTICLE

Fossati-Jimack L, Ling GS, Baudino L, Szajna M, Manivannan K, Zhao JC, Midgley R, Chai J-G, Simpson E, Botto M, Scott Det al., 2015, Intranasal peptide-induced tolerance and linked suppression: consequences of complement deficiency, IMMUNOLOGY, Vol: 144, Pages: 149-157, ISSN: 0019-2805

JOURNAL ARTICLE

Karpus ON, Kiener HP, Niederreiter B, Yilmaz-Elis AS, van der Kaa J, Ramaglia V, Arens R, Smolen JS, Botto M, Tak PP, Verbeek JS, Hamann Jet al., 2015, CD55 deposited on synovial collagen fibers protects from immune complex-mediated arthritis, ARTHRITIS RESEARCH & THERAPY, Vol: 17, ISSN: 1478-6354

JOURNAL ARTICLE

Pekkarinen PT, Heikkila N, Kisand K, Peterson P, Botto M, Daha MR, Drouet C, Isaac L, Helminen M, Haahtela T, Meri S, Jarva H, Arstila TPet al., 2015, Dysregulation of adaptive immune responses in complement C3-deficient patients, EUROPEAN JOURNAL OF IMMUNOLOGY, Vol: 45, Pages: 915-921, ISSN: 0014-2980

JOURNAL ARTICLE

Saja MF, Baudino L, Jackson WD, Cook HT, Malik TH, Fossati-Jimack L, Ruseva M, Pickering MC, Woollard KJ, Botto Met al., 2015, Triglyceride-Rich Lipoproteins Modulate the Distribution and Extravasation of Ly6C/Gr1(low) Monocytes, CELL REPORTS, Vol: 12, Pages: 1802-1815, ISSN: 2211-1247

JOURNAL ARTICLE

Sumida T, Naito AT, Nomura S, Nakagawa A, Higo T, Hashimoto A, Okada K, Sakai T, Ito M, Yamaguchi T, Oka T, Akazawa H, Lee J-K, Minamino T, Offermanns S, Noda T, Botto M, Kobayashi Y, Morita H, Manabe I, Nagai T, Shiojima I, Komuro Iet al., 2015, Complement C1q-induced activation of beta-catenin signalling causes hypertensive arterial remodelling, NATURE COMMUNICATIONS, Vol: 6, ISSN: 2041-1723

JOURNAL ARTICLE

Banda NK, Mehta G, Chao Y, Wang G, Inturi S, Fossati-Jimack L, Botto M, Wu L, Moghimi SM, Simberg Det al., 2014, Mechanisms of complement activation by dextran-coated superparamagnetic iron oxide (SPIO) nanoworms in mouse versus human serum, PARTICLE AND FIBRE TOXICOLOGY, Vol: 11, ISSN: 1743-8977

JOURNAL ARTICLE

Baudino L, Sardini A, Ruseva MM, Fossati-Jimack L, Cook HT, Scott D, Simpson E, Botto Met al., 2014, C3 opsonization regulates endocytic handling of apoptotic cells resulting in enhanced T-cell responses to cargo-derived antigens, PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, Vol: 111, Pages: 1503-1508, ISSN: 0027-8424

JOURNAL ARTICLE

Bossi F, Tripodo C, Rizzi L, Bulla R, Agostinis C, Guarnotta C, Munaut C, Baldassarre G, Papa G, Zorzet S, Ghebrehiwet B, Ling GS, Botto M, Tedesco Fet al., 2014, C1q as a unique player in angiogenesis with therapeutic implication in wound healing, PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, Vol: 111, Pages: 4209-4214, ISSN: 0027-8424

JOURNAL ARTICLE

Giacomassi C, Ling GS, Strid J, Dazzi F, Botto Met al., 2014, Complement C3 exacerbates skin inflammation in a murine model of imiquimod-induced psoriasis, IMMUNOLOGY, Vol: 143, Pages: 120-120, ISSN: 0019-2805

JOURNAL ARTICLE

Ling GS, Bennett J, Woollard KJ, Szajna M, Fossati-Jimack L, Taylor PR, Scott D, Franzoso G, Cook HT, Botto Met al., 2014, Integrin CD11b positively regulates TLR4-induced signalling pathways in dendritic cells but not in macrophages, NATURE COMMUNICATIONS, Vol: 5, ISSN: 2041-1723

JOURNAL ARTICLE

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