Imperial College London
Alternate

ProfessorMarinaBotto

Faculty of Medicine, Department of Immunology and Inflammation

Head of Department, Director of Bioservices
 
 
 
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Contact

 

+44 (0)20 3313 2316m.botto Website

 
 
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Assistant

 

Miss Claudia Rocchi +44 (0)20 3313 2315

 
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Location

 

9N10Commonwealth BuildingHammersmith Campus

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Summary

 

Publications

Publication Type
Year
to

215 results found

Humphries MM, Kenna PF, Campbell M, Tam LCS, Nguyen ATH, Farrar GJ, Botto M, Kiang AS, Humphries Pet al., 2011, C1q enhances cone photoreceptor survival in a mouse model of autosomal recessive retinitis pigmentosa., European Journal of Human Genetics

Journal article

Boross P, Arandhara VL, Martin-Ramirez J, Santiago-Raber M-L, Carlucci F, Flierman R, van der Kaa J, Breukel C, Claassens JWC, Camps M, Lubberts E, Salvatori D, Rastaldi MP, Ossendorp F, Daha MR, Cook HT, Izui S, Botto M, Verbeek JSet al., 2011, The Inhibiting Fc Receptor for IgG, FcγRIIB, Is a Modifier of Autoimmune Susceptibility, JOURNAL OF IMMUNOLOGY, Vol: 187, Pages: 1304-1313, ISSN: 0022-1767

Journal article

Ling GS, Cook HT, Botto M, Lau YL, Huang FPet al., 2011, An essential protective role of IL-10 in the immunological mechanism underlying resistance vs susceptibility to lupus induction by dendritic cells and dying cells, Rheumatology, Vol: 50, Pages: 1773-1784, ISSN: 1462-0332

Objective. To define the role of IL-10 in lupus pathogenesis, and to understand the immunological mechanisms underlying resistance vs susceptibility to lupus disease induction by dendritic cells (DCs) and dying cells.Methods. Groups of IL-10-deficient and normal C57BL/6 mice were injected with syngenic DCs that had ingested necrotic cells prepared by either freeze–thaw cycle (DC/necF/T) or heat shock (DC/necH/S) procedures, or with DC or necrotic cells alone, or with PBS only. Disease development, including proteinuria and renal pathological changes, was monitored. Levels of autoantibodies against different lupus-associated nuclear antigens were measured by ELISAs, and IC deposition in the kidneys was confirmed by immunostaining.Results. No significant proteinuria was detected in the mice. However, striking renal pathological changes typical of IC-mediated GN were consistently observed in the DC/necF/T-treated IL-10−/− mice. These included glomerular hypercellularity and macrophage infiltration, renal IC deposition, circulating kidney-reactive autoantibodies and the presence of immunoglobulin G2 isotype-specific antibody complexes in the diseased kidneys. We demonstrated further that host-derived IL-10 was primarily responsible for protecting against the induction of pathogenic Th1 type of autoantibody responses in the mice.Conclusion. IL-10 protects against the induction of lupus-like renal end-organ damage by down-regulating pathogenic Th1 responses.

Journal article

McDonald JU, Cortini A, Rosas M, Fossati-Jimack L, Ling GS, Lewis KJ, Dewitt S, Liddiard K, Brown GD, Jones SA, Hallett MB, Botto M, Taylor PRet al., 2011, <i>In vivo</i> functional analysis and genetic modification of <i>in vitro</i>-derived mouse neutrophils, FASEB JOURNAL, Vol: 25, Pages: 1972-1982, ISSN: 0892-6638

Journal article

de Jorge EG, Macor P, Paixao-Cavalcante D, Rose KL, Tedesco F, Cook HT, Botto M, Pickering MCet al., 2011, The Development of Atypical Hemolytic Uremic Syndrome Depends on Complement C5, JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY, Vol: 22, Pages: 137-145, ISSN: 1046-6673

Journal article

Lunardi A, Gaboli M, Giorgio M, Rivi R, Bygrave A, Antoniou M, Drabek D, Dzierzak E, Fagioli M, Salmena L, Botto M, Cordon-Cardo C, Luzzatto L, Pelicci PG, Grosveld F, Pandolfi PPet al., 2011, A Role for PML in Innate Immunity., Genes Cancer, Vol: 2, Pages: 10-9

Journal article

Malik TH, Cortini A, Carassiti D, Boyle JJ, Haskard DO, Botto Met al., 2010, The Alternative Pathway Is Critical for Pathogenic Complement Activation in Endotoxin- and Diet-Induced Atherosclerosis in Low-Density Lipoprotein Receptor-Deficient Mice, CIRCULATION, Vol: 122, Pages: 1948-U122, ISSN: 0009-7322

Journal article

Bodin K, Ellmerich S, Kahan MC, Tennent GA, Loesch A, Gilbertson JA, Hutchinson WL, Mangione PP, Gallimore JR, Millar DJ, Minogue S, Dhillon AP, Taylor GW, Bradwell AR, Petrie A, Gillmore JD, Bellotti V, Botto M, Hawkins PN, Pepys MBet al., 2010, Antibodies to human serum amyloid P component eliminate visceral amyloid deposits, NATURE, Vol: 468, Pages: 93-97, ISSN: 0028-0836

Journal article

Pickering MC, Botto M, 2010, Are anti-C1q antibodies different from other SLE autoantibodies?, NATURE REVIEWS RHEUMATOLOGY, Vol: 6, Pages: 490-493, ISSN: 1759-4790

Journal article

Harhausen D, Prinz V, Ziegler G, Gertz K, Endres M, Lehrach H, Gasque P, Botto M, Stahel PF, Dirnagl U, Nietfeld W, Trendelenburg Get al., 2010, CD93/AA4.1: A Novel Regulator of Inflammation in Murine Focal Cerebral Ischemia, JOURNAL OF IMMUNOLOGY, Vol: 184, Pages: 6407-6417, ISSN: 0022-1767

Journal article

Carlucci F, Fossati-Jimack L, Dumitriu IE, Heidari Y, Walport MJ, Szajna M, Baruah P, Garden OA, Cook HT, Botto Met al., 2010, Identification and Characterization of a Lupus Suppressor 129 Locus on Chromosome 3, JOURNAL OF IMMUNOLOGY, Vol: 184, Pages: 6256-6265, ISSN: 0022-1767

Journal article

Baruah P, Simpson E, Dumitriu IE, Derbyshire K, Coe D, Addey C, Dyson J, Chai J-G, Cook T, Scott D, Botto Met al., 2010, Mice lacking C1q or C3 show accelerated rejection of minor H disparate skin grafts and resistance to induction of tolerance, EUROPEAN JOURNAL OF IMMUNOLOGY, Vol: 40, Pages: 1758-1767, ISSN: 0014-2980

Journal article

Mehta P, Norsworthy PJ, Hall AE, Kelly SJ, Walport MJ, Botto M, Pickering MCet al., 2010, SLE with C1q deficiency treated with fresh frozen plasma: a 10-year experience, RHEUMATOLOGY, Vol: 49, Pages: 823-824, ISSN: 1462-0324

Journal article

Lee HM, Wysoczynski M, Liu R, Shin D-M, Kucia M, Botto M, Ratajczak J, Ratajczak MZet al., 2010, Mobilization studies in complement-deficient mice reveal that optimal AMD3100 mobilization of hematopoietic stem cells depends on complement cascade activation by AMD3100-stimulated granulocytes, LEUKEMIA, Vol: 24, Pages: 573-582, ISSN: 0887-6924

Journal article

Ten VS, Yao J, Ratner V, Sosunov S, Fraser DA, Botto M, Sivasankar B, Morgan BP, Silverstein S, Stark R, Polin R, Vannucci SJ, Pinsky D, Starkov AAet al., 2010, Complement Component C1q Mediates Mitochondria-Driven Oxidative Stress in Neonatal Hypoxic-Ischemic Brain Injury, JOURNAL OF NEUROSCIENCE, Vol: 30, Pages: 2077-2087, ISSN: 0270-6474

Journal article

Carlucci F, Cook HT, Garg A, Pepys MB, Botto Met al., 2010, Lack of Effect of a Single Injection of Human C-Reactive Protein on Murine Lupus or Nephrotoxic Nephritis, ARTHRITIS AND RHEUMATISM, Vol: 62, Pages: 245-249, ISSN: 0004-3591

Journal article

Leung VWY, Yun S, Botto M, Mason JC, Malik TH, Song W, Paixao-Cavalcante D, Pickering MC, Boyle JJ, Haskard DOet al., 2009, Decay-Accelerating Factor Suppresses Complement C3 Activation and Retards Atherosclerosis in Low-Density Lipoprotein Receptor-Deficient Mice, AMERICAN JOURNAL OF PATHOLOGY, Vol: 175, Pages: 1757-1767, ISSN: 0002-9440

Journal article

Woodman ME, Cooley AE, Avdiushko R, Bowman A, Botto M, Wooten RM, van Rooijen N, Cohen DA, Stevenson Bet al., 2009, Roles for phagocytic cells and complement in controlling relapsing fever infection, JOURNAL OF LEUKOCYTE BIOLOGY, Vol: 86, Pages: 727-736, ISSN: 0741-5400

Journal article

Tsoni SV, Kerrigan AM, Marakalala MJ, Srinivasan N, Duffield M, Taylor PR, Botto M, Steele C, Brown GDet al., 2009, Complement C3 Plays an Essential Role in the Control of Opportunistic Fungal Infections, INFECTION AND IMMUNITY, Vol: 77, Pages: 3679-3685, ISSN: 0019-9567

Journal article

Botto M, Kirschfink M, Macor P, Pickering MC, Wuerzner R, Tedesco Fet al., 2009, Complement in human diseases: Lessons from complement deficiencies, MOLECULAR IMMUNOLOGY, Vol: 46, Pages: 2774-2783, ISSN: 0161-5890

Journal article

Lewis MJ, Malik TH, Ehrenstein MR, Boyle JJ, Botto M, Haskard DOet al., 2009, Immunoglobulin M Is Required for Protection Against Atherosclerosis in Low-Density Lipoprotein Receptor-Deficient Mice, CIRCULATION, Vol: 120, Pages: 417-U101, ISSN: 0009-7322

Journal article

Paixao-Cavalcante D, Hanson S, Botto M, Cook HT, Pickering MCet al., 2009, Factor H facilitates the clearance of GBM bound iC3b by controlling C3 activation in fluid phase, MOLECULAR IMMUNOLOGY, Vol: 46, Pages: 1942-1950, ISSN: 0161-5890

Journal article

Baruah P, Dumitriu IE, Malik TH, Cook HT, Dyson J, Scott D, Simpson E, Botto Met al., 2009, C1q enhances IFN-γ production by antigen-specific T cells via the CD40 costimulatory pathway on dendritic cells, BLOOD, Vol: 113, Pages: 3485-3493, ISSN: 0006-4971

Journal article

Chevrier S, Genton C, Kallies A, Karnowski A, Otten LA, Malissen B, Malissen M, Botto M, Corcoran LM, Nutt SL, Acha-Orbea Het al., 2009, CD93 is required for maintenance of antibody secretion and persistence of plasma cells in the bone marrow niche, PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, Vol: 106, Pages: 3895-3900, ISSN: 0027-8424

Journal article

Paixao-Cavalcante D, Botto M, Cook HT, Pickering MCet al., 2009, Shiga toxin-2 results in renal tubular injury but not thrombotic microangiopathy in heterozygous factor H-deficient mice, CLINICAL AND EXPERIMENTAL IMMUNOLOGY, Vol: 155, Pages: 339-347, ISSN: 0009-9104

Journal article

Heidari Y, Fossati-Jimack L, Carlucci F, Walport MJ, Cook HT, Botto Met al., 2009, A lupus-susceptibility C57BL/6 locus on chromosome 3 (Sle 18) contributes to autoantibody production in 129 mice, GENES AND IMMUNITY, Vol: 10, Pages: 47-55, ISSN: 1466-4879

Journal article

Yun S, Leung VWY, Botto M, Boyle JJ, Haskard DOet al., 2008, Brief report: Accelerated atherosclerosis in low-density lipoprotein receptor-deficient mice lacking the membrane-bound complement regulator CD59, ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY, Vol: 28, Pages: 1714-1716, ISSN: 1079-5642

Journal article

Pickering MC, Macor P, Fish J, Durigutto P, Bossi F, Petry F, Botto M, Tedesco Fet al., 2008, Complement C1q and C8β deficiency in an individual with recurrent bacterial meningitis and adult-onset systemic lupus erythematosus-like illness, RHEUMATOLOGY, Vol: 47, Pages: 1588-1589, ISSN: 1462-0324

Journal article

Yuste J, Sen A, Truedsson L, Jonsson G, Tay L-S, Hyams C, Baxendale HE, Goldblatt F, Botto M, Brown JSet al., 2008, Impaired opsonization with C3b and phagocytosis of <i>Streptococcus pneumoniae</i> in sera from subjects with defects in the classical complement pathway, INFECTION AND IMMUNITY, Vol: 76, Pages: 3761-3770, ISSN: 0019-9567

Journal article

Fossati-Jimack L, Cortes-Hernandez J, Norsworthy PJ, Cook HT, Walport MJ, Botto Met al., 2008, Regulation of B cell tolerance by 129-derived chromosome 1 loci in C57BL/6 mice, ARTHRITIS AND RHEUMATISM, Vol: 58, Pages: 2131-2141, ISSN: 0004-3591

Journal article

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