Publications
215 results found
Fossati-Jimack L, Cortes-Hernandez J, Norsworthy PJ, et al., 2008, C1q deficiency promotes the production of transgenic-derived IgM and IgG3 autoantibodies in anti-DNA knock-in transgenic mice, MOLECULAR IMMUNOLOGY, Vol: 45, Pages: 787-795, ISSN: 0161-5890
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- Citations: 11
Rose KL, Paixao-Cavalcante D, Fish J, et al., 2008, Factor I is required for the development of membranoproliferative glomerulonephritis in factor H-deficient mice, JOURNAL OF CLINICAL INVESTIGATION, Vol: 118, Pages: 608-618, ISSN: 0021-9738
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- Citations: 104
Giacomin PR, Gordon DL, Botto M, et al., 2008, The role of complement in innate, adaptive and eosinophil-dependent immunity to the nematode <i>Nippostrongylus brasiliensis</i>, MOLECULAR IMMUNOLOGY, Vol: 45, Pages: 446-455, ISSN: 0161-5890
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- Citations: 39
Yuste J, Botto M, Bottoms SE, et al., 2007, Serum amyloid P aids complement-mediated immunity to <i>Streptococcus pneumoniae</i>, PLOS PATHOGENS, Vol: 3, Pages: 1208-1219, ISSN: 1553-7366
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- Citations: 80
Rose KL, Paixao-Cavalcante D, Fish J, et al., 2007, Factor I is required for the development of membranoproliferative glomerulonephritis in factor H-deficient mice, MOLECULAR IMMUNOLOGY, Vol: 44, Pages: 3924-3924, ISSN: 0161-5890
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- Citations: 2
Smith RJH, Alexander J, Barlow PN, et al., 2007, New approaches to the treatment of dense deposit disease, JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY, Vol: 18, Pages: 2447-2456, ISSN: 1046-6673
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- Citations: 179
Hepburn AL, Lampert IA, Boyle JJ, et al., 2007, In vivo evidence for apoptosis in the bone marrow in systemic lupus erythematosus, ANNALS OF THE RHEUMATIC DISEASES, Vol: 66, Pages: 1106-1109, ISSN: 0003-4967
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- Citations: 42
Pickering MC, de Jorge EG, Martinez-Barricarte R, et al., 2007, Spontaneous hemolytic uremic syndrome triggered by complement factor H lacking surface recognition domains, Journal of Experimental Medicine, Vol: 204, Pages: 1249-1256, ISSN: 0022-1007
Factor H (FH) is an abundant serum glycoprotein that regulates the alternative pathway of complement-preventing uncontrolled plasma C3 activation and nonspecific damage to host tissues. Age-related macular degeneration (AMD), atypical hemolytic uremic syndrome (aHUS), and membranoproliferative glomerulonephritis type II (MPGN2) are associated with polymorphisms or mutations in the FH gene (Cfh), suggesting the existence of a genotype–phenotype relationship. Although AMD and MPGN2 share pathological similarities with the accumulation of complement-containing debris within the eye and kidney, respectively, aHUS is characterized by renal endothelial injury. This pathological distinction was reflected in our Cfh association analysis, which demonstrated that although AMD and MPGN2 share a Cfh at-risk haplotype, the haplotype for aHUS was unique. FH-deficient mice have uncontrolled plasma C3 activation and spontaneously develop MPGN2 but not aHUS. We show that these mice, transgenically expressing a mouse FH protein functionally equivalent to aHUS-associated human FH mutants, regulate C3 activation in plasma and spontaneously develop aHUS but not MPGN2. These animals represent the first model of aHUS and provide in vivo evidence that effective plasma C3 regulation and the defective control of complement activation on renal endothelium are the critical events in the molecular pathogenesis of FH-associated aHUS.
Woodman ME, Cooley AE, Miller JC, et al., 2007, <i>Borrelia burgdorferi</i> binding of host complement regulator factor H is not required for efficient mammalian infection, INFECTION AND IMMUNITY, Vol: 75, Pages: 3131-3139, ISSN: 0019-9567
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- Citations: 32
Mihai S, Chiriac MT, Takahashi K, et al., 2007, The alternative pathway of complement activation is critical for blister induction in experimental epidermolysis bullosa acquisita, JOURNAL OF IMMUNOLOGY, Vol: 178, Pages: 6514-6521, ISSN: 0022-1767
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- Citations: 73
Ferry H, Potter PK, Crockford TL, et al., 2007, Increased positive selection of B1 cells and reduced B cell tolerance to intracellular antigens in C1q-deficient mice, JOURNAL OF IMMUNOLOGY, Vol: 178, Pages: 2916-2922, ISSN: 0022-1767
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- Citations: 26
Carlucci F, Cortes-Hernandez J, Fossati-Jimack L, et al., 2007, Genetic dissection of spontaneous autoimmunity driven by 129-derived chromosome 1 loci when expressed on C57BL/6 mice, JOURNAL OF IMMUNOLOGY, Vol: 178, Pages: 2352-2360, ISSN: 0022-1767
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- Citations: 54
Rupprecht TA, Angele B, Klein M, et al., 2007, Complement C1q and C3 are critical for the innate immune response to <i>Streptococcus pneumoniae</i> in the central nervous system, JOURNAL OF IMMUNOLOGY, Vol: 178, Pages: 1861-1869, ISSN: 0022-1767
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- Citations: 67
Potter PK, Larbi KY, Nourshargh S, et al., 2007, Efficient clearance of opsonised apoptotic cells in the absence of PECAM-1, MOLECULAR IMMUNOLOGY, Vol: 44, Pages: 1135-1140, ISSN: 0161-5890
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- Citations: 4
Giacomin P, Gordon D, Botto M, et al., 2007, The role of complement in innate, acquired and eosinophil-mediated immunity to the nematode <i>Nippostrongylus brasiliensis</i>, 21st International Complement Workshop, Publisher: PERGAMON-ELSEVIER SCIENCE LTD, Pages: 176-177, ISSN: 0161-5890
Taylor PR, Tsoni SV, Willment JA, et al., 2007, Dectin-1 is required for β-glucan recognition and control of fungal infection, NATURE IMMUNOLOGY, Vol: 8, Pages: 31-38, ISSN: 1529-2908
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- Citations: 873
Pickering MC, Rose KL, Carlucci F, et al., 2007, Increased susceptibility of heterozygous factor H deficient mice to accelerated serum nephrotoxic nephritis, 21st International Complement Workshop, Publisher: PERGAMON-ELSEVIER SCIENCE LTD, Pages: 228-228, ISSN: 0161-5890
Pickering MC, Fish J, Macor P, et al., 2007, Combined C1q and C8β deficiency in a patient with recurrent childhood infections and adult-onset systemic lupus erythematosus, 21st International Complement Workshop, Publisher: PERGAMON-ELSEVIER SCIENCE LTD, Pages: 228-228, ISSN: 0161-5890
Pickering MC, de Jorge EG, Rose KL, et al., 2007, Spontaneous haemolytic uraemic syndrome (HUS) in factor H-deficient mice transgenic for murine factor H protein lacking the five C-terminal domains (FHΔ16-20), 21st International Complement Workshop, Publisher: PERGAMON-ELSEVIER SCIENCE LTD, Pages: 227-228, ISSN: 0161-5890
Bhatia VK, Yun S, Leung V, et al., 2007, Complement C1q reduces early atherosclerosis in low-density lipoprotein receptor-deficient mice, AMERICAN JOURNAL OF PATHOLOGY, Vol: 170, Pages: 416-426, ISSN: 0002-9440
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- Citations: 114
Fossati-Jimack L, Cortes-Hernandez J, Norsworthy P, et al., 2007, C1q can alter the levels of IgM autoantibody production in anti-DNA transgenic models, 21st International Complement Workshop, Publisher: PERGAMON-ELSEVIER SCIENCE LTD, Pages: 171-171, ISSN: 0161-5890
Manderson AP, Quah B, Botto M, et al., 2006, A novel mechanism for complement activation at the surface of B cells following antigen binding, JOURNAL OF IMMUNOLOGY, Vol: 177, Pages: 5155-5162, ISSN: 0022-1767
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- Citations: 6
Turnberg D, Lewis M, Moss J, et al., 2006, Complement activation contributes to both glomerular and tubulointerstitial damage in adriamycin nephropathy in mice, JOURNAL OF IMMUNOLOGY, Vol: 177, Pages: 4094-4102, ISSN: 0022-1767
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- Citations: 69
Heidari Y, Bygrave AE, Rigby RJ, et al., 2006, Identification of chromosome intervals from 129 and C57BL/6 mouse strains linked to the development of systemic lupus erythematosus, GENES AND IMMUNITY, Vol: 7, Pages: 592-599, ISSN: 1466-4879
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- Citations: 33
Lewis MJ, Botto M, 2006, Complement deficiencies in humans and animals: Links to autoimmunity, AUTOIMMUNITY, Vol: 39, Pages: 367-378, ISSN: 0891-6934
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- Citations: 70
Mihai S, Chiriac MT, Takahashi K, et al., 2006, The alternative pathway of complement activation is critical for the induction of experimental epidermolysis bullosa acquisita, 36th Annual Meeting of the European-Society-of-Dermatology-Research (ESDR), Publisher: NATURE PUBLISHING GROUP, Pages: 21-21, ISSN: 0022-202X
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- Citations: 1
Gaspal FMC, McConnell FM, Kim M-Y, et al., 2006, The generation of thymus-independent germinal centers depends on CD40 but not on CD154, the T cell-derived CD40-ligand, EUROPEAN JOURNAL OF IMMUNOLOGY, Vol: 36, Pages: 1665-1673, ISSN: 0014-2980
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- Citations: 37
Pickering MC, Warren J, Rose KL, et al., 2006, Prevention of C5 activation ameliorates spontaneous and experimental factor H-deficient glomerulonephritis in mice, PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, Vol: 103, Pages: 9649-9654, ISSN: 0027-8424
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- Citations: 117
Cook HT, Botto M, 2006, Mechanisms of disease: the complement system and the pathogenesis of systemic lupus erythematosus, NATURE CLINICAL PRACTICE RHEUMATOLOGY, Vol: 2, Pages: 330-337, ISSN: 1745-8382
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- Citations: 98
Yuste J, Ali S, Sriskandan S, et al., 2006, Roles of the alternative complement pathway and C1q during innate immunity to <i>Streptococcus pyogenes</i>, JOURNAL OF IMMUNOLOGY, Vol: 176, Pages: 6112-6120, ISSN: 0022-1767
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- Citations: 33
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