Imperial College London
Alternate

ProfessorMarinaBotto

Faculty of Medicine, Department of Immunology and Inflammation

Head of Department, Director of Bioservices
 
 
 
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Contact

 

+44 (0)20 3313 2316m.botto Website

 
 
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Assistant

 

Miss Claudia Rocchi +44 (0)20 3313 2315

 
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Location

 

9N10Commonwealth BuildingHammersmith Campus

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Summary

 

Publications

Publication Type
Year
to

215 results found

Carlucci F, Cortes-Hernandez J, Fossati-Jimack LM, Bygrave AE, Cook TH, Vyse TJ, Botto Met al., 2006, Genetic contribution of 129 chromosome 1 intervals to autoimmunity in C57BL/6 mice, BSR Annual Meeting/BHPR Spring Meeting, Publisher: OXFORD UNIV PRESS, Pages: I4-I4, ISSN: 1462-0324

Conference paper

Tas SW, Quartier P, Botto M, Fossati-Jimack Let al., 2006, Macrophages from patients with SLE and rheumatoid arthritis have defective adhesion in vitro, while only SLE macrophages have impaired uptake of apoptotic cells, ANNALS OF THE RHEUMATIC DISEASES, Vol: 65, Pages: 216-221, ISSN: 0003-4967

Journal article

Manderson AP, Carlucci F, Lachmann PJ, Lazarus RA, Festenstein RJ, Cook HT, Walport MJ, Botto Met al., 2006, The <i>in vivo</i> expression of actin/salt-resistant hyperactive DNase I inhibits the development of anti-ssDNA and anti-histone autoantibodies in a murine model of systemic lupus erythematosus, ARTHRITIS RESEARCH & THERAPY, Vol: 8, ISSN: 1478-6354

Journal article

Trendelenburg M, Fossati-Jimack L, Cortes-Hernandez J, Turnberg D, Lewis M, Izui S, Cook HT, Botto Met al., 2005, The role of complement in cryoglobulin-induced immune complex glomerulonephritis, JOURNAL OF IMMUNOLOGY, Vol: 175, Pages: 6909-6914, ISSN: 0022-1767

Journal article

Giacomin PR, Wang H, Gordon DL, Botto M, Dent LAet al., 2005, Loss of complement activation and leukocyte adherence as <i>Nippostrongylus brasiliensis</i> develops within the murine host, INFECTION AND IMMUNITY, Vol: 73, Pages: 7442-7449, ISSN: 0019-9567

Journal article

Ten VS, Sosunov SA, Mazer SP, Stark RI, Caspersen C, Sughrue ME, Botto M, Connolly ES, Pinsky DJet al., 2005, C1q-deficiency is neuroprotective against hypoxic-ischemic brain injury in neonatal mice, STROKE, Vol: 36, Pages: 2244-2250, ISSN: 0039-2499

Journal article

Yuste J, Botto M, Paton JC, Holden DW, Brown JSet al., 2005, Additive inhibition of complement deposition by pneumolysin and PspA facilitates <i>Streptococcus pneumoniae</i> septicemia, JOURNAL OF IMMUNOLOGY, Vol: 175, Pages: 1813-1819, ISSN: 0022-1767

Journal article

Botto M, 2005, What knockout mice have taught us about the pathogenesis of lupus, Annual European Congress of Rheumatology, Publisher: BMJ PUBLISHING GROUP, Pages: 53-53, ISSN: 0003-4967

Conference paper

Exley RM, Shaw J, Mowe E, Sun YH, West NP, Williamson M, Botto M, Smith H, Tang CMet al., 2005, Available carbon source influences the resistance of <i>Neisseria meningitidis</i> against complement, JOURNAL OF EXPERIMENTAL MEDICINE, Vol: 201, Pages: 1637-1645, ISSN: 0022-1007

Journal article

Haskard DO, Bhatia V, Boyle JJ, Mason JC, Botto Met al., 2005, Role of complement and complement regulatory proteins in atherosclerosis, 75th Congress of the European-Atherosclerosis-Society, Publisher: ELSEVIER IRELAND LTD, Pages: 39-39, ISSN: 1567-5688

Conference paper

Monk CR, Spachidou M, Rovis F, Leung E, Botto M, Lechler RI, Garden OAet al., 2005, MRL/Mp CD4+,CD25-T cells show reduced sensitivity to suppression by CD4+,CD25+regulatory T cells in vitro - A novel defect of T cell regulation in systemic lupus erythematosus, ARTHRITIS AND RHEUMATISM, Vol: 52, Pages: 1180-1184, ISSN: 0004-3591

Journal article

Hepburn AL, Ng WF, Layton M, Lampert IA, Botto M, Mason JCet al., 2005, In vivo evidence for apoptosis in the bone marrow in SLE, Joint Meeting of the British-Society-for-Rheumatology/Deutsche-Gesellschaft-fur-Rheumatologie and Spring Meeting of the British-Health-Professionals-in-Rheumatology, Publisher: OXFORD UNIV PRESS, Pages: I135-I135, ISSN: 1462-0324

Conference paper

Quartier P, Potter PK, Ehrenstein MR, Walport MJ, Botto Met al., 2005, Predominant role of IgM-dependent activation of the classical pathway in the clearance of dying cells by murine bone marrow-derived macrophages <i>in vitro</i>, EUROPEAN JOURNAL OF IMMUNOLOGY, Vol: 35, Pages: 252-260, ISSN: 0014-2980

Journal article

Cortes-Hernandez J, Fossati-Jimack L, Petry F, Loos M, Izui S, Walport MJ, Cook HT, Botto Met al., 2004, Restoration of C1q levels by bone marrow transplantation attenuates autoimmune disease associated with C1q deficiency in mice, EUROPEAN JOURNAL OF IMMUNOLOGY, Vol: 34, Pages: 3713-3722, ISSN: 0014-2980

Journal article

Stokol T, O'Donnell P, Xiao L, Knight S, Stavrakis G, Botto M, von Andrian UH, Mayadas TNet al., 2004, C1q governs deposition of circulating immune complexes and leukocyte Fcγ receptors mediate subsequent neutrophil recruitment, JOURNAL OF EXPERIMENTAL MEDICINE, Vol: 200, Pages: 835-846, ISSN: 0022-1007

Journal article

Trendelenburg M, Manderson AP, Fossati-Jimack L, Walport MJ, Botto Met al., 2004, Monocytosis and accelerated activation of lymphocytes in C1q-deficient autoimmune-prone mice, IMMUNOLOGY, Vol: 113, Pages: 80-88, ISSN: 0019-2805

Journal article

Turnberg D, Botto M, Lewis M, Zhou WD, Sacks SH, Morgan BP, Walport MJ, Cook HTet al., 2004, CD59a deficiency exacerbates ischemia-reperfusion injury in mice, AMERICAN JOURNAL OF PATHOLOGY, Vol: 165, Pages: 825-832, ISSN: 0002-9440

Journal article

Bygrave AE, Rose KL, Cortes-Hernandez J, Warren J, Rigby RJ, Cook HT, Walport MJ, Vyse TJ, Botto Met al., 2004, Spontaneous autoimmunity in 129 and C57BL/6 mice - Implications for autoimmunity described in gene-targeted mice, PLOS BIOLOGY, Vol: 2, Pages: 1081-1090, ISSN: 1544-9173

Journal article

Fonseca MI, Zhou J, Botto M, Tenner AJet al., 2004, Absence of C1q leads to less neuropathology in transgenic mouse models of Alzheimer's disease, JOURNAL OF NEUROSCIENCE, Vol: 24, Pages: 6457-6465, ISSN: 0270-6474

Journal article

Hutchinson WL, Herbert J, Botto M, Pepys MBet al., 2004, Classical and alternative pathway complement activation are not required for reactive systemic AA amyloid deposition in mice, IMMUNOLOGY, Vol: 112, Pages: 250-254, ISSN: 0019-2805

Journal article

Norsworthy PJ, Fossati-Jimack L, Cortes-Hernandez J, Taylor PR, Bygrave AE, Thompson RD, Nourshargh S, Walport MJ, Botto Met al., 2004, Murine CD93 (C1qRp) contributes to the removal of apoptotic cells in vivo but is not required for C1q-mediated enhancement of phagocytosis, JOURNAL OF IMMUNOLOGY, Vol: 172, Pages: 3406-3414, ISSN: 0022-1767

Journal article

Yamada M, Oritani K, Kaisho T, Ishikawa J, Yoshida H, Takahashi I, Kawamoto S, Ishida N, Ujiie H, Masaie H, Botto M, Tomiyama Y, Matsuzawa Yet al., 2004, Complement C1q regulates LPS-induced cytokine production in bone marrow-derived dendritic cells, EUROPEAN JOURNAL OF IMMUNOLOGY, Vol: 34, Pages: 221-230, ISSN: 0014-2980

Journal article

Mead RJ, Neal JW, Griffiths MR, Linington C, Botto M, Lassmann H, Morgan BPet al., 2004, Deficiency of the complement regulator CD59a enhances disease severity, demyelination and axonal injury in murine acute experimental allergic encephalomyelitis, LABORATORY INVESTIGATION, Vol: 84, Pages: 21-28, ISSN: 0023-6837

Journal article

Botto M, 2004, Phosphatidylserine receptor and apoptosis: consequences of a non-ingested meal, Arthritis Research & Therapy, Vol: 6, Pages: 147-150

Journal article

Manderson AP, Botto M, Walport MJ, 2004, The role of complement in the development of systemic lupus erythematosus, ANNUAL REVIEW OF IMMUNOLOGY, Vol: 22, Pages: 431-456, ISSN: 0732-0582

Journal article

Gillmore JD, Hutchinson WL, Mitchell DA, Herbert J, Botto M, Walport MJ, Pepys MBet al., 2003, Studies of serum amyloid P component (SAP) and antinuclear autoimmunity., 36th Annual Meeting of the American-Society-of-Nephrology, Publisher: AMER SOC NEPHROLOGY, Pages: 167A-168A, ISSN: 1046-6673

Conference paper

Turnberg D, Botto M, Warren J, Zhou WD, Sacks SH, Morgan P, Walport MJ, Cook Tet al., 2003, CD59a deficiency exacerbates adriamycin nephropathy and ischaemia-reperfusion injury in mice., 36th Annual Meeting of the American-Society-of-Nephrology, Publisher: LIPPINCOTT WILLIAMS & WILKINS, Pages: 163A-163A, ISSN: 1046-6673

Conference paper

Stäger S, Alexander J, Kirby AC, Botto M, Van Rooijen N, Smith DF, Brombacher F, Kaye PMet al., 2003, Natural antibodies and complement are endogenous adjuvants for vaccine-induced CD8<SUP>+</SUP> T-cell responses, NATURE MEDICINE, Vol: 9, Pages: 1287-1292, ISSN: 1078-8956

Journal article

Turnberg D, Botto M, 2003, The regulation of the complement system: insights from genetically-engineered mice, MOLECULAR IMMUNOLOGY, Vol: 40, Pages: 145-153, ISSN: 0161-5890

Journal article

Trendelenburg M, Hernandes-Cortes J, Walport SIMJ, Cook HT, Fossati-Jimack L, Botto Met al., 2003, The role of complement in cryoglobulin-induced immune complex glomerulonephritis, 9th European Meeting on Complement in Human Disease, Publisher: PERGAMON-ELSEVIER SCIENCE LTD, Pages: 192-192, ISSN: 0161-5890

Conference paper

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