Imperial College London
Alternate

ProfessorMarinaBotto

Faculty of Medicine, Department of Immunology and Inflammation

Head of Department, Director of Bioservices
 
 
 
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Contact

 

+44 (0)20 3313 2316m.botto Website

 
 
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Assistant

 

Miss Claudia Rocchi +44 (0)20 3313 2315

 
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Location

 

9N10Commonwealth BuildingHammersmith Campus

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Summary

 

Publications

Citation

BibTex format

@article{Sattler:2014:10.1016/j.jaut.2014.01.032,
author = {Sattler, S and Ling, G-S and Xu, D and Hussaarts, L and Romaine, A and Zhao, H and Fossati-Jimack, L and Malik, T and Cook, HT and Botto, M and Lau, Y-L and Smits, HH and Liew, FY and Huang, F-P},
doi = {10.1016/j.jaut.2014.01.032},
journal = {Journal of Autoimmunity},
pages = {107--122},
title = {IL-10-producing regulatory B cells induced by IL-33 (Breg(IL-33)) effectively attenuate mucosal inflammatory responses in the gut},
url = {http://dx.doi.org/10.1016/j.jaut.2014.01.032},
volume = {50},
year = {2014}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - Regulatory B cells (Breg) have attracted increasing attention for their roles in maintaining peripheral tolerance. Interleukin 33 (IL-33) is a recently identified IL-1 family member, which leads a double-life with both pro- and anti-inflammatory properties. We report here that peritoneal injection of IL-33 exacerbated inflammatory bowel disease in IL-10-deficient (IL-10−/−) mice, whereas IL-33-treated IL-10-sufficient (wild type) mice were protected from the disease induction. A phenotypically unconventional subset(s) (CD19+CD25+CD1dhiIgMhiCD5-CD23-Tim-1-) of IL-10 producing Breg-like cells (BregIL-33) was identified responsible for the protection. We demonstrated further that BregIL-33 isolated from these mice could suppress immune effector cell expansion and functions and, upon adoptive transfer, effectively blocked the development of spontaneous colitis in IL-10−/− mice. Our findings indicate an essential protective role, hence therapeutic potential, of BregIL-33 against mucosal inflammatory disorders in the gut.
AU  - Sattler,S
AU  - Ling,G-S
AU  - Xu,D
AU  - Hussaarts,L
AU  - Romaine,A
AU  - Zhao,H
AU  - Fossati-Jimack,L
AU  - Malik,T
AU  - Cook,HT
AU  - Botto,M
AU  - Lau,Y-L
AU  - Smits,HH
AU  - Liew,FY
AU  - Huang,F-P
DO  - 10.1016/j.jaut.2014.01.032
EP  - 122
PY  - 2014///
SN  - 0896-8411
SP  - 107
TI  - IL-10-producing regulatory B cells induced by IL-33 (Breg(IL-33)) effectively attenuate mucosal inflammatory responses in the gut
T2  - Journal of Autoimmunity
UR  - http://dx.doi.org/10.1016/j.jaut.2014.01.032
UR  - http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000336114600014&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=1ba7043ffcc86c417c072aa74d649202
UR  - https://www.sciencedirect.com/science/article/pii/S0896841114000377?via%3Dihub
VL  - 50
ER  -
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