Imperial College London


Faculty of MedicineDepartment of Medicine

Director of Bioservices, Professor of Rheumatology



+44 (0)20 3313 2316m.botto Website




Miss Claudia Rocchi +44 (0)20 3313 2315




9N10Commonwealth BuildingHammersmith Campus





Christopher Parish, Cell-Cell Interaction GroupDivision of Immunology and Cell BiologyJohn Curtin School of Medical ResearchAustralian National UniversityCanberra, Australia, 2000

C TerhorstA Sharpe, Harvard Medical SchoolBoston, USA, 2000

Francesco Tedesco, Dept. Physiology and PathologyUniversity of TriesteTrieste, Italy, 1999

Sjef Verbeek, Leiden University Medical Centre (LUMC) Department of Human Genetics Leiden, The Netherlands, 1999

Richard Smith, Division of NephrologyThe University of IowaIowa City, USA, 2006

Izui Shozo, Department of PathologyC.M.U.Geneva, Switzerland, 2000

Jeremy Brown, Centre for Respiratory ResearchRoyal Free and University College Medical SchoolRayne InstituteLondon, 2000

Richard Cornall, University of Oxford, 1999

Steven Sacks, Department of Nephrology and TransplanationGuy’s HospitalLondon, 2001

Paul MorganPhilip Taylor, University of Wales College of MedicineDept of Medical Biochemistry Cardiff, 1999 - 1999

Mark Pepys, Department of Medicine Royal Free and University College Medical SchoolLondon, 1999

S Rodriguez de Córdoba, Departamento de InmunologíaCentro de Investigaciones Biológicas (CSIC)Velázquez 144, 28006-Madrid, SPAIN, 2001

Guest Lectures

KFO 249 Symposium, Dresden, Germany, 2012

Immune Tolerance and Autoimmune Disease meeting 2012, Cambridge, United Kingdom, 2012

13° Corso Post-Universitario in Immunologia Clinica and Giorgio De Sandre Commemorative Conference, Verona, Italy, 2012

BSI Conference 2011, Liverpool, United Kingdom, 2011

Chronic Inflammation Program (ChIP) Symposium, Lund, Sweden, 2011

Fifth EULAR Course on Systemic Lupus Erythematosus, Pisa, Italy, 2011

Mouse Molecular Genetics Conference, Hinxton, United Kingdom, 2011

13th European Meeting on Complement in Human Disease, Leiden, The Netherlands, 2011

Swedish Society for Immunology Annual Meeting, Stockholm, Sweden, 2011

1st International Congress on Controversies in Rheumatology and Autoimmunity (CORA), Florence, Italy, 2011

XXIII International Complement Workshop, New York, USA, 2010

BSI Pre-Conference Symposia at the British Society of Rheumatology Annual Conference, Birmingham, United Kingdom, 2010

1st Imperial College Kidney and Transplant Institute Lupus Meeting, London, United Kingdom, 2010

11° Corso Post-Universitario in Immunologia Clinica, Verona, Italy, 2010

XVI Symposium of the "Reina Sofia" Institute of the Íñigo Álvarez de Toledo Renal Foundation, Madrid, Spain, 2009

Advanced Course: The Role of B cells in the Physiology and Pathology of the Immune System, Sorrento, Italy, 2009

2nd Gordon Research Conference on Antigen Cross-Presentation, Lucca, Italy, 2009

IUIS Expert Meeting on Primary Immunodeficiencies, Dublin, Ireland, 2009

ECM - 9° Congresso Nazionale Associazione Italiana di Miologia, Verona, Italy, 2009

British Society for Rheumatology Annual Meeting, Glasgow, United Kingdom, 2009

Immunology Regional Group Seminar, Aberdeen, United Kingdom, 2008

VII MD International Symposium on Autoimmunity, Vienna, Austria, 2008

XIII Meeting of the European Society for Immunodeficiencies (ESID), Hertogenbosch, The Netherlands, 2008

2nd Annual Symposium for SLE, Boston, United States, 2008

XXII International Complement Workshop, Basel, Switzerland, 2008

7th European Lupus Meeting, Amsterdam, The Netherlands, 2008

Discoveries Strategies Conference, San Francisco, United States, 2008

9° Corso Post-Universitario in Immunologia Clinica, Verona, Italy, 2007

11th European Meeting on Complement in Human Disease, Cardiff, United Kingdom, 2007

2nd Conference of Societa’ Italiana di Immunologia and Immunologia Clinica & Allergologia, Verona, Italy, 2003

Symposium on Frontiers in Lupus Nephritis, London, United Kingdom, 2003

American Society of Nephrology meeting, Philadelphia, USA, 2005

Immunology Programme Research seminar series, New York, USA, 2004

3rd International Conference on Autoimmunity, Rhodes, Greece

1st Course in Genetics of Rheumatic and Auto-inflammatory diseases, Bologna, Italy, 2007

Visit to Johns Hopkins University, Baltimore,USA, 2007

The Biomarkers and New Therapies in SLE Workshop, London, United Kingdom, 2007

2nd Bergamo Workshop on Hemolytic Uremic Syndrome, Bergamo, Italy, 2006

ACR Annual Scientific Meeting, Washington,DC, USA, 2006

1st Nordic Meeting on Genetics and Pathogenesis of Immunological Diseases, Helsinki, Finland, 2006

European Society for Cinical Investigation, Verona, Italy, 2003

2nd Workshop on Complement Associated Diseases, Animal models and Therapeutics, Myconos, Greece, 2003

Gordon Conference, Connecticut, USA, 2003

7th International Lupus Congress, New York, USA, 2004

34th Annual Scientific Meeting of the Australasian Society for Immunology (ASI), Adelaide, Australia, 2004

7th FIMSA/ASI Advanced Training Course in Immunology, Adelaide, Australia, 2004

6th European Lupus Meeting, London, The British Society for Rheumatology, 2005

12th European Pedriatic Rheumatology Congress, Versailles, France, 2005

Annual European Congress of Rheumatology 'Eular 2005', Viena, Austria, 2005

Research Student Supervision

Ali,S, Characterisation of primary B cell defects in autoimmune-prone mice

Ambrose,N, The use of skin blisters to dissect the abnormal inflammatory response to monosodium urate crystals in Behçet’s Syndrome

Atcha,H, Analysis of the role of complement C3 in atherosclerosis in mice

Barbour,T, The role of complement fragment IC3b in dense deposit disease




Buang,N, Genetic and cellular mechanisms of autoimmunity in animal models and humans


Chun,J, Renal plasmacells (PCs) contribution to systemic autoantibody titres in a congenic model of SLE

D'Alessandri,T, The Role of Th2 and IgE Immunity in Lymphoid Stress Surveillance

Fish,J, Candidate Gene Analysis of QTLs Associated with Defective Apoptotic Cell Clearance in a Murine Model of Autoimmune Disease

Giacomassi,C, The contribution of complement to the immunomodulating role of mesenchymal stem cells

Ishaque,A, Analysis of T cells expressing a lupus suppressor locus (Sle18)


Manivannan,K, Regulatory T cells in DAF and C3 Knock-Out Mice: Peripheral Tolerance Gone Bad?



Panse,K, The role of pro-inflammatory cytokine IL-6 in the pathogenesis of SLE in the B6.129chr1b murine model of lupus



Rahman,T, Phenotypic analysis of a mouse congenic line predisposed to lupus like disease

Romaine,A, Investigating the role of ITGAM in TLR 9 signalling

Saja,M, The Role of Hyperlipidaemia in Promoting Renal Injury in Autoimmune Disease: Dissecting the Molecular Mechanisms

Tahir,S, Analysis of the role of complement in the T cell response



Vernon,K, The role of local complement Factor H in complement mediated renal disease

Yasuga,H, T cell trafficking in an induced mouse model of autoimmunity